Cine MRI during spontaneous cramps in women with menstrual pain

Hellman, Kevin M.; Kuhn, Caroline; Tu, Frank F.; Dillane, Katlyn E; Shlobin, Nathan A.; Senapati, S.; Zhou, Xin; Li, Wei; Prasad, Pottumarthi V.

doi:10.1016/j.ajog.2018.01.035

Cited by 19 publications

(14 citation statements)

References 29 publications

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“…This study was approved by the NorthShore University HealthSystem Institutional Review Board. Following written informed consent, participants with severe dysmenorrhea and healthy controls (ages 18–45) were prospectively recruited from physician referral or from participation in separate studies 18 between January 2012 and February 2017. Dysmenorrhea participants were allowed to have chronic pelvic pain diagnoses, given the substantial co-morbidity.…”

Section: Methodsmentioning

confidence: 99%

“…After the first 14 participants, we opted to switch our pain recording apparatus to allow for a more rapid indication of cramping pain with a squeeze-bulb validated previously. 18 Dysmenorrheic participants were instructed to proportionally squeeze the bulb to indicate their increased pain during a menstrual cramp. Participants were instructed to squeeze the bulb only when they experienced pain above their baseline.…”

Section: Methodsmentioning

confidence: 99%

“…However, we have shown that myometrial events often precede spontaneous pain report with MRI. 18 Although direct evidence that abdominal muscle activity causes pain is lacking, an observational study evaluating the effects of lidocaine injections into abdominal muscle trigger points in dysmenorrhea supports this role. 10…”

Section: Commentmentioning

confidence: 99%

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Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea

Oladosu

Farhan

et al. 2018

American Journal of Obstetrics and Gynecology

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Abdominal muscle activity may contribute to cramping pain in primary dysmenorrhea but is resolvable with naproxen. Dysmenorrheic patients without cramp-associated abdominal muscle activity exhibit widespread pain sensitivity (lower pressure pain thresholds) and are more likely to also have a chronic pain diagnosis, suggesting their cramps are linked to changes in central pain processes. This preliminary study suggests new tools to phenotype menstrual pain and supports the hypothesis that multiple distinct mechanisms may contribute to dysmenorrhea.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea

Oladosu

Farhan

et al. 2018

American Journal of Obstetrics and Gynecology

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“…Participants included in this study were enrolled between March 2015 and November 2017. Some participant data from the MRI and ultrasound study has already been published 6, 7 . The method in this paper was used in those prior studies 6, 7 to investigate the role of uterine contractions and abdominal muscle activity in menstrual pain.…”

Section: Methodsmentioning

confidence: 99%

“…To validate a new metric for evaluating spontaneous pain and its temporal characteristics, we investigated women with menstrual period pain, clinically known as dysmenorrhea. Previously, a hand‐held squeeze bulb was used to characterize the temporal relationship between cramping pain and uterine activity with magnetic resonance imaging (MRI) 6 or abdominal muscle activity with Electromyography, 7 however, this method to measure pain intensity was not validated. We tested the hypothesis that worse global self‐reported rating of menstrual cramping pain is associated with more prolonged, intense, and frequent bulb squeezing pain bouts in women with dysmenorrhea.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a real‐time method characterizing spontaneous pain in women with dysmenorrhea

Kantarovich

Dillane

Garrison

et al. 2021

J of Obstet and Gynaecol

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Aim Prior research has primarily focused on static pain assessment, largely ignoring the dynamic nature of pain over time. We used a novel assessment tool for characterizing pain duration, frequency, and amplitude in women with dysmenorrhea and evaluated how these metrics were affected by naproxen treatment. Methods Dysmenorrheic women (n = 25) rated their menstrual pain by squeezing a pressure bulb proportional to the magnitude of their pain. To evaluate whether bulb squeezing was affected by naproxen, we compared parameters before and after naproxen. We also analyzed the correlation between pain relief on a numerical rating scale to changes in bulb squeezing parameters. Random bulb‐squeezing activity in pain‐free participants (n = 14) was used as a control for nonspecific effects or bias. Results In dysmenorrheic women, naproxen reduced the duration of the squeezing during a painful bout, the number of painful bouts and bout intensity. Before naproxen, the correlation between these bulb squeeze parameters and self‐reported pain on numeric rating scale was not significant (R2 = 0.12, p = 0.304); however, there was a significant correlation between changes in bulb squeeze activity and self‐reported pain relief after naproxen (R2 = 0.55, p < 0.001). Conclusion Our study demonstrates a convenient technique for continuous pain assessment, capturing three different dimensions: duration, frequency, and magnitude. Naproxen may act by reducing the duration and frequency of episodic pain in addition to reducing the severity. After further validation, these methods could be used for other pain conditions for deeper phenotyping and assessing novel treatments.

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Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target

Zheng

Liu

Guo

2023

Reprod Medicine & Biology

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PurposeTo screen Zn2+‐dependent histone deacetylase (HDAC) 1‐11 in endometriotic cells and then evaluated the HDACs identified from the screening in ovarian endometrioma (OE) and deep endometriotic (DE) lesions, and to evaluate the therapeutic potential of HDAC8 inhibition in mice.MethodsQuantification of gene and protein expression levels of HDAC1‐11 in endometriotic cells stimulated by TGF‐β1, and immunohistochemistry analysis of Class I HDACs and HDAC6 in OE/DE lesion samples. The therapeutic potential of HDAC8 inhibition was evaluated by a mouse model of deep endometriosis.ResultsThe screening identified Class I HDACs and HDAC6 as targets of interest. Immunohistochemistry analysis found a significant elevation in HDAC8 immunostaining in both OE and DE lesions, which was corroborated by gene and protein expression quantification. For other Class I HDACs and HDAC6, their lesional expression was more subtle and nuanced. HDAC1 and HDAC6 staining was significantly elevated in DE lesions while HDAC2 and HDAC3 staining was reduced in DE lesions. Treatment of mice with induced deep endometriosis with an HDAC8 inhibitor resulted in significantly longer hotplate latency, a reduction of lesion weight by nearly two‐thirds, and significantly reduced lesional fibrosis.ConclusionsThese findings highlight the progression‐dependent nature of specific HDAC aberrations in endometriosis, and demonstrate, for the first titme, the therapeutic potential of suppressing HDAC8.

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Cine MRI during spontaneous cramps in women with menstrual pain

Cited by 19 publications

References 29 publications

Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea

Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea

Development and validation of a real‐time method characterizing spontaneous pain in women with dysmenorrhea

Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target

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