Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana

Cheng, Guiguang; Cai, Xiang‐Hai; Zhang, Baohong; Li, Yan; Gu, Jiande; Bao, Ming; Liu, Yaping; Luo, Xiao‐Dong

doi:10.1055/s-0033-1360279

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…The consumption of cinchona is not associated with health risks [30][31][32]. The Cinchona succirubra bark powder used for the nutraceutical formulation was provided by NGN Healthcare New Generation Nutraceuticals srl.…”

Section: Supplementationmentioning

confidence: 99%

The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study

Chiurazzi,

De Conno,

Di Lauro

et al. 2023

Nutrients

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Obesity is a risk factor for several diseases present worldwide. Currently, dietary changes and physical activity are considered the most effective treatment to reduce obesity and its associated comorbidities. To promote weight loss, hypocaloric diets can be supported by nutraceuticals. The aim of this study was to evaluate the effects of a hypocaloric diet associated with Cinchona succirubra supplementation on satiety, body weight and body composition in obese subjects. Fifty-nine overweight/obese adults, were recruited, randomized into two groups and treated for 2 months. The first group (32 adults) was treated with a hypocaloric diet plus cinchona supplementation (the T-group); the second one (27 adults) was treated with a hypocaloric diet plus a placebo supplementation (the P-group). Anthropometric-measurements as well as bioimpedance analysis, a Zung test and biochemical parameters were evaluated at baseline and after 60 days. T-group adults showed significant improvement in nutritional status and body composition compared to those at the baseline and in the P-group. Moreover, T-group adults did not show a reduction in Cholecystokinin serum levels compared to those of P-group adults. In conclusion, our data demonstrate that a hypocaloric diet associated with cinchona supplementation is effective in inducing more significant weight loss and the re-establishment of metabolic parameters than those obtained with a hypocaloric diet.

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Section: Supplementationmentioning

confidence: 99%

The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study

Chiurazzi,

De Conno,

Di Lauro

et al. 2023

Nutrients

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“…Quinidine is used as a cardiac depressant or as an antiarrhythmic agent in heart attacks. Other two major alkaloid quinoline components, namely, cinchonidine (the nonmethoxylated form of quinine) and cinchonine (the nonmethoxylated form of quinidine), act as antisporozoan compounds and antidotes to toxins (Cheng et al, 2014). They may also be applied as eye lotions, painkillers, antibacterial precursors, astringents, hemorrhoid and ulcer treatments, and hair growth stimulants (De-Villiers et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Genetic profiles of three Cinchona species in Junghuhn Natural Reserve, Indonesia

Sasongko¹,

Yuniati²,

Billmora³

2021

SABRAOJBG

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Cinchona species were widely used as ancient medicines for different diseases because they contain the active component quinine and its derivatives. However, studies on the molecular aspects of cinchona, including its genetic diversity, have not been reported because most previous works focused on the administration of the antimalarial cinchona alkaloid. Quinine is also being tested as alternative compound for the treatment of Covid-19. The Junghuhn Natural Reserve in Indonesia contains three different types of cinchona plants, namely, Cinchona calisaya, Cinchona pubescens, and Cinchona sp. Given that the genetic diversity and kinship of these species have never been studied, collecting data on the cinchona gene pool has become imperative. This study analyzed the genetic diversity of the cinchona species in the Junghuhn Natural Reserve, Indonesia, by using eight RAPD markers, i.e., OPA-2, OPA-9, OPB-02, OPB-03, OPB-04, OPB-05, OPB-7, and OPJ-07, during 2020 at the University of Jenderal Soedirman, Purwokerto-Indonesia. Polymorphic band data were obtained. Then, phenogram analysis was conducted by using UPGMA and maximum parsimony with MEGA7. The RAPD profiles of Cinchona species (C. calisaya, C. pubescent, and Cinchona sp.) revealed polymorphism with different markers, i.e., OPA-2 (90%), OPB-2 (75%), OPB-5 (75%), OPB-3 (66.66%), OPB-4 (66.66%), OPB-7 (66.66%), OPJ-7 (66.66%), and OPA-9 (58.33%) sequentially with total polymorphism (70.62%). C. calisaya was identified as the most distinctive species. UPGMA yielded a coefficient of 0.200 and two distinctive groups: Group I, which comprised C. pubescens and Cinchona sp. with the p-distance value of 0.333, and Group II, which contained C. calisaya. Ixora sp. was treated as an outgroup plant. The topology of the dendrogram was consistent with that of the UPGMA dendrogram. Results may be used for the further exploration of the genetic diversity of cinchona species.

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“…Searching for optimized or simplified indole alkaloids has been the spotlight of antitumor drug discovery for several years. In our continual search for natural antitumor products from medicinal plants, indole alkaloids were found to be the most potent candidates in a cytotoxicity bioassay against five human cancer cell lines [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]. Among these cytotoxic indoles, 3 α -acetonyltabersonine, an aspidosperma-type monoterpenoid indole alkaloid, structurally similar to vindoline, showed the best bioactivity, with IC 50 values of 0.2–0.6 μM against human myeloid leukemia HL-60 cells, hepatocellular carcinoma SMMC-7721 cells, lung cancer A549 cells, breast cancer MCF-7 cells, and colon cancer SW480 cells.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair

Zhao

Xiao-fang

et al. 2017

Toxins

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Cytotoxic indole alkaloids from Melodinus suaveolens, which belongs to the toxic plant family Apocynaceae, demonstrated impressive antitumor activities in many tumor types, but less application in glioblastoma, which is the lethal brain tumor. In the present study, we reported the anti-glioblastoma activity of an indole alkaloid, 3α-acetonyltabersonine, which was isolated from Melodinus suaveolens. 3α-acetonyltabersonine was cytotoxic to glioblastoma cell lines (U87 and T98G) and stem cells at low concentrations. We verified 3α-acetonyltabersonine could suppress tumor cell proliferation and cause apoptosis in glioblastoma stem cells (GSCs). Moreover, detailed investigation of transcriptome study and Western blotting analysis indicated the mitogen activated protein kinase (MAPK) pathway was activated by phosphorylation upon 3α-acetonyltabersonine treatment. Additionally, we found 3α-acetonyltabersonine inhibited DNA damage repair procedures, the accumulated DNA damage stimulated activation of MAPK pathway and, finally, induced apoptosis. Further evidence was consistently obtained from vivo experiments on glioblastoma mouse model: treatment of 3α-acetonyltabersonine could exert pro-apoptotic function and prolong the life span of tumor-bearing mice. These results in vitro and in vivo suggested that 3α-acetonyltabersonine could be a potential candidate antitumor agent.

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Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana

Cited by 8 publications

References 37 publications

The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study

The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study

Genetic profiles of three Cinchona species in Junghuhn Natural Reserve, Indonesia

Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair

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