Ciliated cyst of the gallbladder: A new case and literature review

Triki, Wissem; Baraket, Oussama; Itami, Atsushi; Baccar, Abdelmajid; Ines, Marzouk; Bouchoucha, Sami

doi:10.1016/j.ijscr.2017.12.024

Cited by 3 publications

(6 citation statements)

References 16 publications

(12 reference statements)

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“…However, CFCs of the gallbladder are extremely rare. Only 13 cases of CFC of the gallbladder, including the present case, have been reported till date [ 1 , 4 – 14 ] ( Table 1 ). The median age was 39 years, with a range of 9–72 years.…”

Section: Discussionmentioning

confidence: 99%

“…It is often difficult to radiographically distinguish between benign and malignant CFCs. Most cases of gallbladder CFCs reported anechoic features on US and nonenhanced findings on CT [ 1 , 4 – 14 ] ( Table 1 ). In the present case, CT revealed a contrast-enhanced lesion with an unclear border along the liver, suggesting the possibility of malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…For gallbladder CFCs, some researchers insist that close surveillance is recommended when the cyst is asymptomatic [ 7 ], while others suggest excision should be performed due to its tendency for malignant transformation [ 4 , 13 , 14 ]. The biological behavior of CFCs of the gallbladder is not yet understood because of CFCs' rarity, and malignant CFCs of the gallbladder have not been reported to date [ 1 , 4 – 14 ] ( Table 1 ). However, malignancy can arise in hepatic CFCs [ 2 , 16 – 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the histological similarity between these two types of CFCs, the possibility of similar changes in gallbladder CFCs should be considered. Additionally, nine out of 13 cases of gallbladder CFCs in the literature search presented with abdominal pain [ 1 , 4 – 14 ] ( Table 1 ). Therefore, surgical excision is needed to rule out benign or malignant lesions and resolve patients' symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Gallbladder Ciliated Foregut Cyst Suspected of Malignancy Preoperatively

Tsutsumi

Abe

Kuga

et al. 2021

Case Reports in Surgery

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Background. Gallbladder ciliated foregut cysts (CFCs) of the lower diaphragm are extremely rare. Furthermore, they are rarely suspected of malignancy preoperatively. Case Presentation. A 50-year-old woman was referred to our hospital for further examination and treatment of a gallbladder tumor that was detected using abdominal ultrasonography (US). After a close inspection, she was diagnosed with a gallbladder tumor that was possibly malignant. Accordingly, open whole layer cholecystectomy was performed because intraoperative US revealed a tumor located on the intraperitoneal side of the gallbladder, and a rapid intraoperative pathological diagnosis identified no malignancy. A postoperative pathological examination revealed a cystic lesion with thin walls covered with ciliated epithelium, which laid on a connective tissue with smooth muscle fibers. Based on the above results, the final pathological diagnosis was CFC of the gallbladder without malignancy. Conclusions. Cases of gallbladder CFC can be considered as cysts requiring treatment owing to CFCs’ potential for malignant transformation and high-frequency symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gallbladder Ciliated Foregut Cyst Suspected of Malignancy Preoperatively

Tsutsumi

Abe

Kuga

et al. 2021

Case Reports in Surgery

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“…Ταυτόχρονα, ο Agarwal και η ομάδα του, ανακοίνωσαν το πρώτο περιστατικό κύστης εκ κροσσωτού επιθηλίου σε παιδί ηλικίας εννέα ετών. Σύμφωνα με την ανωτέρω μελέτη, η κροσσωτή κύστη του προσθίου εντέρου εμφανίζεται συχνά υποδιαφραγματικά, κυρίως σε επαφή με τους βρόγχους ή τον οισοφάγο 127,128.…”

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Διερεύνηση Ανοσοϊστοχημικών Δεικτών Με Συμμετοχή Στο Επιθήλιο Της Χοληδόχου Κύστης Στη Λιθογένεση

Οικονόμου¹

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Σκοπός της παρούσας μελέτης ήταν η διερεύνηση της έκφρασης των τριών ανοσοϊστοχημικών δεικτών Beclin1, LC3a και Ki67 στο επιθήλιο της χοληδόχου κύστης και η συσχέτιση της φλεγμονώδους διεργασίας με την οξεία χολοκυστίτιδα, την αυτοφαγική διαδικασία και την χολολιθίαση. Πραγματοποιήθηκε παθολογοανατομική εξέταση και ανοσοϊστοχημεία σε δείγματα χοληδόχων κύστεων 100 ασθενών που χωρίστηκαν σε δύο ομάδες, την ομάδα Α και την ομάδα Β. Η ομάδα Α περιλάμβανε 70 ασθενείς που υποβλήθησαν σε χολοκυστεκτομή λόγω χολολιθίασης, ενώ η Β 30 ασθενείς με αλιθιασικό επιθήλιο χοληδόχου κύστης. Υψηλότερη έκφραση του Beclin 1 και Ki67 παρατηρήθηκε στους ασθενείς της ομάδας Α και παράλληλα η αύξηση της έκφρασης του Beclin1 προήγαγε την έκφραση του LC3a στην ίδια ομάδα. Σύμφωνα με τα αποτελέσματα μας, η παρουσία χολόλιθων πιθανολογείται ότι προάγει την φλεγμονή και την αυτοφαγία στο επιθήλιο της χοληδόχου κύστης και ο μηχανισμός της αυτοφαγικής ρύθμισης πιθανότατα διαδραματίζει σημαντικό ρόλο στην χρόνια φλεγμονή και στην πιθανή εξαλλαγή του επιθηλίου.

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Ciliated Foregut Cyst of Gallbladder: A Little Known Entity

Triki¹,

Itami²,

Baraket³

et al. 2018

J Med Surg Pathol

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Ciliated foregut cysts are rare masses that develop from the tissues which remain from embryological foregut development. In the literature, a few cases have been described in various organs so far. The solitary cysts are characterized by ciliated pseudostratified columnar epithelium. They are usually located above the diaphragm but they can also arise in relation to the liver, gallbladder and pancreas. Although rare, there is a risk of development of squamous cell carcinoma from these cysts that typically bear benign features. Prognosis following the development of carcinoma is poor. Congenital gallbladder cysts are detected rather rarely. The diagnosis is suspected on imaging. Treatment using a laparoscopic surgical method is the first preference.

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Ciliated cyst of the gallbladder: A new case and literature review

Abstract: HighlightsNew entity that pathologists must differentiate from other cyst lesions.Study epidemiological and pathological characteristics through a review of literature.Surgical treatment.

Cited by 3 publications

References 16 publications

Gallbladder Ciliated Foregut Cyst Suspected of Malignancy Preoperatively

Gallbladder Ciliated Foregut Cyst Suspected of Malignancy Preoperatively

Διερεύνηση Ανοσοϊστοχημικών Δεικτών Με Συμμετοχή Στο Επιθήλιο Της Χοληδόχου Κύστης Στη Λιθογένεση

Ciliated Foregut Cyst of Gallbladder: A Little Known Entity

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