Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

Pasquin, Sarah; Sharma, Mukut; Gauchat, Jean‐François

doi:10.1016/j.cytogfr.2015.07.007

Cited by 111 publications

(80 citation statements)

References 107 publications

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“…The beneficial effects of CTNF, and IL-6 in nerve regeneration have been presented (20,45,46). Similar to the members of neurotrophic factor family such as BDNF and GDNF, neural survival effect of CTNF is also transient.…”

Section: Basic Effects Of Neuropoeitic Cytokinesmentioning

confidence: 93%

The role of growth factors in nerve regeneration

Önger

Delibaş

Türkmen

et al. 2016

DD&T

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Section: Basic Effects Of Neuropoeitic Cytokinesmentioning

confidence: 93%

The role of growth factors in nerve regeneration

Önger

Delibaş

Türkmen

et al. 2016

DD&T

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“…While the factor has potent therapeutic effects on nerve apoptosis, neuroinflammation, and neuronal proliferation, it has been linked with altered metabolism (due to neurogenesis in the hypothalamus as well as direct action on adipocytes) when administered systemically and may negatively affect osteoblast differentiation and mineralization [120–122]. GDNF, another potent neurotrophic molecule often produced by MSCs, may help to ease allodynia and hyperalgesia experienced in dorsal root ganglia sensory nerves [123].…”

Section: Neural Supportmentioning

confidence: 99%

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

2016

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Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. Recently, trophic activities of MSCs have become the topic of a number of revealing studies that span both basic and clinical fields. In this review, we focus on recent investigations that have elucidated trophic mechanisms and shed light on MSC clinical efficacy relevant to musculoskeletal applications. Innate differences due to MSC sourcing may play a role in the clinical utility of isolated MSCs. Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined. Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. Classic growth factors and cytokines—such as VEGF, CNTF, GDNF, TGF-β, interleukins (IL-1β, IL-6, and IL-8), and C-C ligands (CCL-2, CCL-5, and CCL-23)—serve as paracrine control molecules secreted or packaged into extracellular vesicles, or exosomes, by MSCs. Recent studies have also implicated signaling by microRNAs contained in MSC-derived exosomes. The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. Trophic activities of MSCs, either resident or introduced exogenously, are thus intricately controlled, and may be further fine-tuned via implant material modifications. MSCs are actively being investigated for the repair and regeneration of both osteochondral and other musculoskeletal tissues, such as tendon/ligament and meniscus. Future rational and effective MSC-based musculoskeletal therapies will benefit from better mechanistic understanding of MSC trophic activities, for example using analytical “-omics” profiling approaches.

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“…CNTF administration promotes the in vitro survival and differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes under physiological conditions and during white matter injury (M. Mayer et al, 1994; Pasquin, Sharma, & Gauchat, 2015; Talbott et al, 2007; Tripathi & Mctigue, 2008). Compared to LIF, CNTF is a stronger promoter of neurogenesis in vivo (Bauer et al, 2007).…”

Section: Ciliary Neurotrophic Factormentioning

confidence: 99%

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Davis

Pennypacker

2018

Pharmacology & Therapeutics

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Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

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Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

Cited by 111 publications

References 107 publications

The role of growth factors in nerve regeneration

The role of growth factors in nerve regeneration

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

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