Ciliary activity on adenoids of patients with otitis media with effusion

Ōhashi, Y.; Nakai, Yousuke; Nakata, Junko; Koshimo, Hiroyuki; Esaki, Yusuke; Ikeoka, Hiroshi; Osako, Shigeto

doi:10.1016/s0196-0709(88)80040-1

Cited by 20 publications

(2 citation statements)

References 20 publications

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“…Only a few studies were aimed at the evaluation of CBF in patients with AH. Ohashi et al observed that participants with otitis media with effusion (OME) had significantly decreased ciliary activity of the adenoidal surface compared with those with no episode of otitis media or those with otitis media without effusion. All patients had significantly lower ciliary activity compared to that found in normal guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

Ciliary beat frequency in children with adenoid hypertrophy

Marusiakova

Ďurdík

Jeseňák

et al. 2020

Pediatric Pulmonology

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Background Children with adenoid hypertrophy (AH) have impaired respiratory system defense mechanisms, such as mucociliary clearance. We hypothesized that AH negatively affects one of the most important aspects of mucociliary clearance—ciliary beat frequency (CBF) and that adenoidectomy could potentially restore this essential defence mechanism of the airways. This study evaluated the influence of AH and endoscopic adenoidectomy on the CBF of the nasal respiratory epithelium in children. Methods This prospective study included 64 children with confirmed AH aged 3 to 18 years and 43 age‐ and sex‐matched healthy controls. Nasal CBF was analyzed using a digital high‐speed video microscope and the software application Ciliary Analysis (NI LabVIEW). The preoperative adenoid size was assessed according to Cassano. Clinical symptoms of chronic rhinosinusitis were evaluated using the SNOT‐20 questionnaire. Results Children with AH had a median CBF of 5.35 ± 1.06 Hz. Six months after surgery, the median CBF was significantly higher (6.48 ± 0.88 Hz; P < .001) and reached the values of healthy children (6.37 ± 0.71 Hz; P = .512). The size of the adenoid tissue did not correlate with the CBF. No influence of age or gender on the CBF was found. After adenoidectomy, a significant reduction of the mean total SNOT‐20 score was recorded (P < .01). Conclusion Children with clinically symptomatic AH have impaired mucociliary clearance due to decreased nasal CBF. Removal of hypertrophic adenoid tissue normalizes the CBF and reduces the presence of clinical symptoms of rhinosinusitis.

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Section: Discussionmentioning

confidence: 99%

Ciliary beat frequency in children with adenoid hypertrophy

Marusiakova

Ďurdík

Jeseňák

et al. 2020

Pediatric Pulmonology

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“…It has recently been suggested that C. pneumoniae, like some viral agents, may downregulate cellular apoptosis (23), thereby increasing the possibility of intracellular persistence. Ciliary activity is depressed on the surface of hypertrophic adenoids and in patients with OME (24). A putative mechanism for this may be the ability of C. pneumoniae to depress the ciliary activity on respiratory epithelia (25).…”

Section: Discussionmentioning

confidence: 99%

Chlamydia pneumoniae in children undergoing adenoidectomy

et al. 2001

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Chlamydia pneumoniae is a common respiratory pathogen which is often found in paediatric populations. Little is known about the true colonization rate and the localization of the bacteria in the respiratory tract. In this study, immunohistochemistry was used to examine adenoids from 69 children undergoing elective adenoidectomy. Throat swabs for polymerase chain reaction (PCR) and blood samples for serology were also obtained. Chlamydia pneumoniae was demonstrated in the adenoids by immunohistochemistry in 68 of the children. Five children (7%) had a positive C. pneumoniae PCR test from throat swabs and 14 children (20%) had detectable antibodies by the microimmunofluorescence technique. Conclusion: The results suggest that C pneumoniae is a common finding in the adenoids of children undergoing adenoidectomy. Whether or not C pneumoniae plays a pathogenic role in this patient population could not be determined from the data obtained in this investigation.

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Serous otitis media and paranasopharyngeal extension of nasopharyngeal carcinoma

et al. 1992

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Two hundred thirty-two patients with nasopharyngeal carcinoma were evaluated for serous otitis media (SOM) at diagnosis. The diagnosis of SOM required the detection of effusion behind the tympanic membrane in association of air-bone gap of 10 dB or more in pure tone audiogram. These patients were also evaluated by computed tomography for the degree of tumor extension. By stepwise logistic regression analysis, the degree of paranasopharyngeal extension of tumor, erosion of petrous temporal bone, and the obliteration of pharyngeal recess were significantly related to the development of SOM, but sex and age were not. The findings of computed tomography may influence the plan of management for SOM in patients with nasopharyngeal carcinoma at diagnosis.

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Ciliary activity on adenoids of patients with otitis media with effusion

Cited by 20 publications

References 20 publications

Ciliary beat frequency in children with adenoid hypertrophy

Ciliary beat frequency in children with adenoid hypertrophy

Chlamydia pneumoniae in children undergoing adenoidectomy

Serous otitis media and paranasopharyngeal extension of nasopharyngeal carcinoma

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