Ciliary activity in the in vitro tubotympanum

Ōhashi, Y.; Nakai, Yousuke; Koshimo, Hiroyuki; Esaki, Yusuke

doi:10.1007/bf00460209

Cited by 40 publications

(9 citation statements)

References 13 publications

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“…If gastric content gains access to the middle ear cleft, even at concentrations well below gastric levels, the potential for direct mucosal damage is obvious. The human Eustachian tube is entirely lined by ciliated respiratory epithelium that undergoes ciliostasis and subsequent disruption of mucociliary clearance below a pH of 4 22–24 . Acid and non‐acid EORD can theoretically lead to both functional Eustachian tube obstruction because of impaired mucociliary clearance and incomplete opening, and to true anatomic obstruction from mucosal edema and adenoid hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…The human Eustachian tube is entirely lined by ciliated respiratory epithelium that undergoes ciliostasis and subsequent disruption of mucociliary clearance below a pH of 4. [22][23][24] Acid and non-acid EORD can theoretically lead to both functional Eustachian tube obstruction because of impaired mucociliary clearance and incomplete opening, and to true anatomic obstruction from mucosal edema and adenoid hyperplasia. This leads to impaired pressure equalization with persistent negative pressure, a condition that has been shown to result in middle ear effusions.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Extraesophageal Reflux in Otitis Media in Infants and Children

O’Reilly

Bloedon

et al. 2008

The Laryngoscope

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Pepsin is detectable in the middle ear cleft of 20% of pediatric patients with OM undergoing tympanostomy tube placement, compared with 1.4% of controls; recovery of pepsin in the middle ear space of pediatric patients with OM is an independent risk factor for OM. Patients under 1 year of age have a higher incidence of purulent effusions and pepsin-positive effusions. Clinical history of GERD, allergy, and asthma do not seem to correlate with evidence of EORD reaching the middle ear cleft. The presence of pepsin in the middle ear space at the time of tube placement does not seem to predispose to posttympanostomy tube otorrhea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role of Extraesophageal Reflux in Otitis Media in Infants and Children

O’Reilly

Bloedon

et al. 2008

The Laryngoscope

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“…This is facilitated by a ciliated respiratory tract columnar epithelium that constantly propels mucoid secretions from the middle ear to the nasopharyx. 4,23 The one-way nature of the auditory canal helps prevent infections from ascending from the nasopharynx.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomographic Evidence of Bulla Effusion in Cats with Sinonasal Disease: 2001–2004

Detweiler

Johnson

Kass

et al. 2006

Veterinary Internal Medicne

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Background:Sinonasal disease is common in cats; chronic inflammatory disease and neoplasia are diagnosed most frequently. Radiographic and computed tomographic (CT) findings in nasal disease have been reported, although involvement of other cranial structures has not been fully described to our knowledge. Hypothesis:We hypothesized that neoplastic or inflammatory obstruction of the auditory tube associated with sinonasal disease could result in CT evidence of effusive bulla disease in affected cats. Animals:46 cats with sinonasal disease, 18 control cats. Methods:CT images acquired in cats with (n= 46) and without (n= 18) sinonasal disease were reviewed for evidence of concurrent bulla effusion. CT findings of soft tissue or fluid opacity within the tympanic bulla or thickening of the bone of the bullae were considered evidence of effusive bulla disease. Results:The prevalence of bulla effusion in cats with sinonasal disease was 28% (13/46) and was significantly higher than that observed in cats without sinonasal disease (1/18, P= .043). CT findings that were found in association with effusive bulla disease included imaging features of sinusitis and nasopharyngeal disease. The most common neoplasm associated with bulla effusion was nasopharyngeal lymphoma. Bulla effusion was not observed in any cat with nasal carcinoma. Conclusions and Clinical Importance: Findings of this study suggest that auditory canal dysfunction may play a larger role in feline sinonasal disease than was previously recognized. The implications of these findings for management of cats with chronic inflammatory or neoplastic sinonasal disease require further investigation.

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“…Radiographic evidence has shown that fl uid can traverse the eustachian tube and enter the middle ear cleft from the nasopharynx during swallowing [18]. The ciliated respiratory epithelium that lines the human eustachian tube can undergo ciliostasis and subsequent disruption of mucociliary clearance below a pH of 4 [19][20][21]. Acid and nonacid EORD theoretically can lead to functional eustachian tube obstruction due to impaired mucociliary clearance, incomplete opening, and true anatomic obstruction from mucosal edema and adenoid hyperplasia.…”

Section: Pathophysiology Of Eord In Otitis Mediamentioning

confidence: 99%

Gastric pepsin in middle ear fluid of children with otitis media: Clinical implications

He¹,

O’Reilly

Mehta³

2008

Curr Allergy Asthma Rep

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Gastroesophageal reflux and extraesophageal reflux have been postulated to be involved in the pathogenesis of otitis media. This is supported by recent studies revealing the presence of gastric pepsin in the middle ear space of children with otitis media but not in control patients without otitis media. Reflux's role in otitis media appears to be most pronounced in younger children and those with purulent effusions.

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Ciliary activity in the in vitro tubotympanum

Cited by 40 publications

References 13 publications

The Role of Extraesophageal Reflux in Otitis Media in Infants and Children

The Role of Extraesophageal Reflux in Otitis Media in Infants and Children

Computed Tomographic Evidence of Bulla Effusion in Cats with Sinonasal Disease: 2001–2004

Gastric pepsin in middle ear fluid of children with otitis media: Clinical implications

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