Cilazapril-induced pleural effusion: A case report and review of the literature

Abstract

We describe an unusual case of lymphocytic pleural effusion associated with the use of cilazapril, a novel angiotensin-converting-enzyme inhibitor (ACEI). An 80-year-old male was prescribed cilazapril for hypertension. He subsequently presented with right chest pain and dry cough. He was found to have a lymphocytic pleural effusion on thoracentesis. Extensive workup, including open pleural biopsy, failed to reveal the etiology of the effusion. However, soon after the withdrawal of cilazapril, his clinical symptoms improved and the effusion disappeared. ACEI-induced pleural effusion has only been rarely reported. Drug-induced pleural effusion should be considered when formulating the differential diagnosis in a patient receiving ACEI.

Surgical management of pleuro-peritoneal fistula in chronic renal failure patient—safety and effectiveness

“…Published case reports suggested that ACEI may induce pleural effusion (9). We postulate that ACEI usage may predispose patients to have recurrence of pleural effusion despite receiving VATS for CAPD associated PPF.…”

Cilazapril-induced pleural effusion: A case report and review of the literature

“…We read with interest the article by Kupeli et al . on “Cilazapril-induced pleural effusion: A case report and review of the literature.”[ 1 ] We would like to make the following comments:…”