Ciguatoxin reduces larval survivability in finfish

Edmunds, J. S. G.; McCarthy, Ray; Ramsdell, John S.

doi:10.1016/s0041-0101(99)00119-1

Cited by 54 publications

(24 citation statements)

References 14 publications

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“…developmental toxicity). This model system has been effectively employed to identify developmental toxicity associated with a number of wellrecognized toxins from marine and freshwater HABs Edmunds et al, 1999;Kimm-Brinson and Ramsdell, 2001;Liu et al, 2002;Colman and Ramsdell, 2003;Colman et al, 2004Colman et al, , 2005Lefebvre et al, 2004;Tiedeken et al, 2005). Equally, this system is being increasingly utilized to identify and characterize novel, or otherwise unrecognized, developmental toxins from algal sources (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…For example, both PbTx and the chemically related ciguatoxin (CTx) which both act as neurotoxins via activation of voltage-gated sodium channels, have been shown to impair development of medaka embryos (Edmunds et al, 1999;Kimm-Brinson and Ramsdell, 2001;Colman and Ramsdell, 2003;Colman et al, 2004). Developmental effects, following microinjection of medaka oocytes with both PbTx and CTx, were observed at sub-nanogram and -picogram (per egg) quantities, respectively, and included, in both cases, curvature of the spine, hyperkinesis and cardiovascular (i.e.…”

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

“…Developmental effects, following microinjection of medaka oocytes with both PbTx and CTx, were observed at sub-nanogram and -picogram (per egg) quantities, respectively, and included, in both cases, curvature of the spine, hyperkinesis and cardiovascular (i.e. heart rate) effects (Edmunds et al, 1999;KimmBrinson and Ramsdell, 2001;Colman and Ramsdell, 2003;Colman et al, 2004). Interestingly, there was an observed difference between two congeners of the brevetoxins tested, namely PbTx1 and PbTx3, in terms of their cardiovascular response; specifically, PbTx3-treated (as well as CTx-treated) embryos exhibited persistent tachycardia (Colman and Ramsdell, 2003), as opposed to delayed bradycardia in those exposed to PbTx1 (Kimm-Brinson and Ramsdell, 2001).…”

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

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The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

Berry

Gantar

Gibbs

et al. 2007

Comparative Biochemistry and Physiology Part C: Toxicology &

109

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The zebrafish (Danio rerio) embryo has emerged as an important model of vertebrate development. As such, this model system is finding utility in the investigation of toxic agents that inhibit, or otherwise interfere with, developmental processes (i.e. developmental toxins), including compounds that have potential relevance to both human and environmental health, as well as biomedicine. Recently, this system has been applied increasingly to the study of microbial toxins, and more specifically, as an aquatic animal model, has been employed to investigate toxins from marine and freshwater microalgae, including those classified among the so-called "harmful algal blooms" (HABs). We have developed this system for identification and characterization of toxins from cyanobacteria (i.e. "blue-green algae") isolated from the Florida Everglades and other freshwater sources in South and Central Florida. Here we review the use of this system as it has been applied generally to the investigation of toxins from marine and freshwater microalgae, and illustrate this utility as we have applied it to the detection, bioassay-guided fractionation and subsequent characterization of developmental toxins from freshwater cyanobacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

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The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

Berry

Gantar

Gibbs

et al. 2007

Comparative Biochemistry and Physiology Part C: Toxicology &

109

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“…In addition to their human health effects, algal toxins are responsible for extensive die-offs of fish and shellfish and have been implicated in the episodic mortalities of marine mammals, birds, and other animals dependent on the marine food web. The impacts of algal toxins are generally observed as acute intoxications, whereas the environmental health effects of chronic exposure to low levels of algal toxins are only poorly documented and are an emerging issue (2)(3)(4)(5).…”

mentioning

confidence: 99%

Marine Algal Toxins: Origins, Health Effects, and Their Increased Occurrence

Dolah¹

2000

Environmental Health Perspectives

212

157

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Certain marine algae produce potent toxins that impact human health through the consumption of contaminated shellfish and finfish and through water or aerosol exposure. Over the past three decades, the frequency and global distribution of toxic algal incidents appear to have increased, and human intoxications from novel algal sources have occurred. This increase is of particular concern, since it parallels recent evidence of large-scale ecologic disturbances that coincide with trends in global warming. The extent to which human activities have contributed to their increase therefore comes into question. This review summarizes the origins and health effects of marine algal toxins, as well as changes in their current global distribution, and examines possible causes for the recent increase in their occurrence. Key words: amnesic shellfish poisoning, diarrhetic shellfish poisoning, dinoflagellates, domoic acid, global climate change, harmful algal blooms, marine toxins, neurotoxic shellfish poisoning, okadaic acid, paralytic shellfish poisoning. Marine algal toxins are responsible for an array of human illnesses associated with consumption of seafood and, in some cases, respiratory exposure to aerosolized toxins.

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“…To evaluate the hazard of maternal oocyte transfer, we used microinjection to transfer known amounts of toxin in an oil droplet into freshly fertilized fish eggs. This method has previously been used to characterize the adverse effects of ciguatoxin and chemical contaminants such as DDT (19,20). Both ciguatoxin and DDT bioaccumulate in fish and are found in the gonads; however, to date comparable data has not been reported for brevetoxin.…”

mentioning

confidence: 99%