Ciguatera fish poisoning in France: experience of the French Poison Control Centre Network from 2012 to 2019

Haro, Luc de; Schmitt, C.; Sinno‐Tellier, Sandra; Paret, Nathalie; Boels, D.; Roux, Gaël Le; Langrand, Jérôme; Delcourt, Nicolas; Labadie, Magali; Simon, Nicolas

doi:10.1080/15563650.2020.1788052

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Although, so far, maitotoxin was historically considered one of the most toxic natural compounds, its range of in vivo toxicity described in the literature varies from 50 to 200,000 µg/kg [ 140 , 305 , 306 , 307 , 308 , 309 ]. This is an important fact that needs to be clarified since there are several effects of MTX on cellular regulatory mechanisms, which could make it a molecule with potential use for different purposes, for instance, neurotransmitter secretion [ 310 ], programmed cell death activation [ 311 ], fertilization [ 312 ], and insulinotropic activity since it has been reported that MTX activates non-selective cationic currents (NSCCs) [ 313 , 314 ], becoming a promising new tool available for the development of multiple new therapies for different purposes.…”

Section: Marine Toxins As a Source Of Drugsmentioning

confidence: 99%

Current Trends and New Challenges in Marine Phycotoxins

et al. 2022

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Marine phycotoxins are a multiplicity of bioactive compounds which are produced by microalgae and bioaccumulate in the marine food web. Phycotoxins affect the ecosystem, pose a threat to human health, and have important economic effects on aquaculture and tourism worldwide. However, human health and food safety have been the primary concerns when considering the impacts of phycotoxins. Phycotoxins toxicity information, often used to set regulatory limits for these toxins in shellfish, lacks traceability of toxicity values highlighting the need for predefined toxicological criteria. Toxicity data together with adequate detection methods for monitoring procedures are crucial to protect human health. However, despite technological advances, there are still methodological uncertainties and high demand for universal phycotoxin detectors. This review focuses on these topics, including uncertainties of climate change, providing an overview of the current information as well as future perspectives.

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Section: Marine Toxins As a Source Of Drugsmentioning

confidence: 99%

Current Trends and New Challenges in Marine Phycotoxins

et al. 2022

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“…This syndrome comprises gastrointestinal, neurological, and cardiovascular symptoms (Lehane and Lewis 2000 ). Blooms of these dinoflagellates have expanded worldwide reaching even European coasts (Canals et al 2021 ; de Haro et al 2021 ; Katikou 2021 ; Murray et al 2021 ). The presence of Gambierdiscus species (Canals et al 2021 ; Katikou 2021 ), the related toxins (Tudó et al 2020 ) and CFP intoxications have been repetitively identified in Europe during the last decades (Canals et al 2021 ; Katikou 2021 ), especially in the Canary Islands (Canals et al 2021 ; Perez-Arellano et al 2005 ), Madeira (Otero et al 2010 ) and France (de Haro et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Blooms of these dinoflagellates have expanded worldwide reaching even European coasts (Canals et al 2021 ; de Haro et al 2021 ; Katikou 2021 ; Murray et al 2021 ). The presence of Gambierdiscus species (Canals et al 2021 ; Katikou 2021 ), the related toxins (Tudó et al 2020 ) and CFP intoxications have been repetitively identified in Europe during the last decades (Canals et al 2021 ; Katikou 2021 ), especially in the Canary Islands (Canals et al 2021 ; Perez-Arellano et al 2005 ), Madeira (Otero et al 2010 ) and France (de Haro et al 2021 ). CFP is one of the most common forms of seafood poisoning, caused by the consumption of fish contaminated with ciguatoxins (CTXs) produced by microalgae of the genus Gambierdiscus (Bagnis et al 1979 ) and Fukuyoa (Gomez et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity

et al. 2022

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Ciguatoxins are marine compounds that share a ladder-shaped polyether structure produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa, and include maitotoxins (MTX1 and MTX3), ciguatoxins (CTX3C) and analogues (gambierone), components of one of the most frequent human foodborne illness diseases known as ciguatera fish poisoning. This disease was previously found primarily in tropical and subtropical areas but nowadays, the dinoflagellates producers of ciguatoxins had spread to European coasts. One decade ago, the European Food Safety Authority has raised the need to complete the toxicological available data for the ciguatoxin group of compounds. Thus, in this work, the in vivo effects of ciguatoxin-related compounds have been investigated using internationally adopted guidelines for the testing of chemicals. Intraperitoneal acute toxicity was tested for maitotoxin 1 at doses between 200 and 3200 ng/kg and the acute oral toxicity of Pacific Ciguatoxin CTX3C at 330 and 1050 ng/kg and maitotoxin 1 at 800 ng/kg were also evaluated showing not effects on mice survival after a 96 h observation period. Therefore, for the following experiments the oral subchronic doses were between 172 and 1760 ng/kg for gambierone, 10 and 102 ng/kg for Pacific Ciguatoxin CTX3C, 550 and 1760 ng/kg for maitotoxin 3 and 800, 2560 and 5000 ng/kg for maitotoxin 1. The results presented here raise the need to reevaluate the in vivo activity of these agents. Although the intraperitoneal lethal dose of maitotoxin 1 is assumed to be 50 ng/kg, without chemical purity identifications and description of the bioassay procedures, in this work, an intraperitoneal lethal dose of 1107 ng/kg was obtained. Therefore, the data presented here highlight the need to use a common procedure and certified reference material to clearly establish the levels of these environmental contaminants in food.

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“…However, species implicated in CP can have wide geographical ranges, e.g., the Nassau grouper ( Epinephelus striatus ) transcend the jurisdictions of 43 nations or territories [ 142 ], or have a relatively small spatial home and hunting ranges, with occasional sporadic movements for spawning aggregations and migrations. Consumer avoidance of CP risk species can become complicated when identifiable characteristics used for phenotypically determining a species, like the head or skin, are removed during processing [ 143 , 144 ] or when species hybridize [ 145 ]. Therefore, the policies guiding CP harvest restrictions can be subverted by deliberate or inadvertent species substitution [ 146 ], or by falsifying capture location information [ 147 ].…”

Section: Introductionmentioning

confidence: 99%

“…Challenges to fully understanding the CP impacts on humans are numerous and include: (i) difficulties in identification and misdiagnosis due to diverse unspecific symptomology (e.g., gastrointestinal, neurologic, and cardiac) [ 143 ], (ii) severity related to consumption habits (what parts of the animal were eaten and how much) [ 114 ], (iii) patient pre-existing conditions or existing CTX body burden, (iv) willingness to seek treatment [ 164 , 165 ], (v) whether the healthcare system considers ciguatera to be a reportable illness [ 11 , 166 ], (vi) globalized intertwined food networks [ 146 , 167 ], and (vii) international trade and travel where the source of illness (traceback) can be difficult to ascertain [ 144 , 168 ]. In most CP incidents, symptoms are mild or self-resolving, a frequently cited reason for underreporting issues related to ciguatera.…”

Section: Introductionmentioning

confidence: 99%

Ciguatera Mini Review: 21st Century Environmental Challenges and the Interdisciplinary Research Efforts Rising to Meet Them

Loeffler

Tartaglione

Friedemann

et al. 2021

IJERPH

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Globally, the livelihoods of over a billion people are affected by changes to marine ecosystems, both structurally and systematically. Resources and ecosystem services, provided by the marine environment, contribute nutrition, income, and health benefits for communities. One threat to these securities is ciguatera poisoning; worldwide, the most commonly reported non-bacterial seafood-related illness. Ciguatera is caused by the consumption of (primarily) finfish contaminated with ciguatoxins, potent neurotoxins produced by benthic single-cell microalgae. When consumed, ciguatoxins are biotransformed and can bioaccumulate throughout the food-web via complex pathways. Ciguatera-derived food insecurity is particularly extreme for small island-nations, where fear of intoxication can lead to fishing restrictions by region, species, or size. Exacerbating these complexities are anthropogenic or natural changes occurring in global marine habitats, e.g., climate change, greenhouse-gas induced physical oceanic changes, overfishing, invasive species, and even the international seafood trade. Here we provide an overview of the challenges and opportunities of the 21st century regarding the many facets of ciguatera, including the complex nature of this illness, the biological/environmental factors affecting the causative organisms, their toxins, vectors, detection methods, human-health oriented responses, and ultimately an outlook towards the future. Ciguatera research efforts face many social and environmental challenges this century. However, several future-oriented goals are within reach, including digital solutions for seafood supply chains, identifying novel compounds and methods with the potential for advanced diagnostics, treatments, and prediction capabilities. The advances described herein provide confidence that the tools are now available to answer many of the remaining questions surrounding ciguatera and therefore protection measures can become more accurate and routine.

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Ciguatera fish poisoning in France: experience of the French Poison Control Centre Network from 2012 to 2019

Cited by 8 publications

References 9 publications

Current Trends and New Challenges in Marine Phycotoxins

Current Trends and New Challenges in Marine Phycotoxins

In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity

Ciguatera Mini Review: 21st Century Environmental Challenges and the Interdisciplinary Research Efforts Rising to Meet Them

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