Cigarette smoking, gastric acidity and peptic ulceration

Kaufmann, Damian; Wilder‐Smith, Clive H.; Kempf, Marie; Neumann, Joyce; Schmolls, H.; Witzel, L; Walt, R P; Röhmel, Joachim; Merki, H. S.

doi:10.1007/bf01540565

Cited by 20 publications

(7 citation statements)

References 44 publications

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“…A slightly lower median intragastric pH in smoking smokers compared to non-smokers was observed during the day and especially after meals (56). In agreement with this study, nasally administered nicotine significantly decreased postprandial intragastric pH (57).…”

Section: Twenty-four-hour Ph Profiles In Healthsupporting

confidence: 69%

“…Both the circadian pattern of gastric acidity and the intragastric pH values of DU patients were not related to the ulcer activity, since gastric acidity was similar in the presence of an endoscopically proved active ulcer, early (6 weeks) and late (6 months) after healing of the ulcer (64). Moreover, no effects of gender, age or smoking on the gastric acidity were found in DU (18,56,62). H. pylori-positive patients with DU showed similar intragastric acidities and BAO and MAO values as did H. pylori-negative DU patients (65,66).…”

Section: Twenty-four Hour Ph Profiles In Diseasementioning

confidence: 71%

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24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

Herwaarden¹,

Samsom²,

Smout³

1999

Scandinavian Journal of Gastroenterology

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van Herwaarden MA, Samsom M, Smout AJPM. 24-h recording of intragastric pH: technical aspects and clinical relevance. Scand J Gastroenterol 1999;34 Suppl 230:9-16.Background: Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of intragastric pH monitoring in research and clinical practice. Methods: Literature review. Results: Most studies on intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of intragastric pH monitoring are expressed either as median H activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on intragastric pH is barely affected by the H. pylori status. Conclusions: Despite some limitations, intragastric pH monitoring provides important information about gastric acidity.

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Section: Twenty-four-hour Ph Profiles In Healthsupporting

confidence: 69%

Section: Twenty-four Hour Ph Profiles In Diseasementioning

confidence: 71%

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

Herwaarden¹,

Samsom²,

Smout³

1999

Scandinavian Journal of Gastroenterology

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“…Chronic smoking is associated with higher gastric acid secretion in subjects with and without ulcer. [64][65][66][67] In addition, there is a significant positive association between the number of cigarettes smoked and the magnitude of acid secretion. 68 Nicotine administrated intravenously stimulates acid secretion in humans.…”

Section: Discussionmentioning

confidence: 99%

Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected withHelicobacter pylori

et al. 2006

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Background: Acid secretion is intimately associated with most upper gastrointestinal diseases. Helicobacter pylori infection is a major environmental factor modifying acid secretion. Aim: To study the association between the pattern of H pylori gastritis and gastric secretory function in a large number of subjects without specific upper gastrointestinal disease. Methods and materials: Maximal acid output (MAO) was measured in 255 patients with dyspepsia showing normal endoscopy. Activity and severity of gastritis, atrophy and H pylori infection were assessed in body and antral biopsies. The correlations of histological parameters as well as age, sex, height, weight, smoking, serum gastrin, pepsinogen I and II, and their ratio with MAO were determined. Multiple linear regression was used to show the best possible predictors of MAO. Results: Negative relationships: Body atrophy and body-combined (active and chronic) inflammatory scores showed a potent inverse correlation with MAO (correlation coefficients (CC) 0.59 and 0.50, respectively). Body:antral chronic gastritis ratio and body:antral combined inflammation ratio (both with CC = 0.49) and age (CC = 0.44) were also inversely correlated with MAO. Intestinal metaplasia at both antral and body sites had negative relationships with acid output with CC = 0.23 and 0.20, respectively. Positive relationships: Serum pepsinogen I, body H pylori density:combined inflammation ratio and pepsinogen I:II ratio with CC of 0.38, 0.38 and 0.30, respectively, correlated with MAO. The H pylori density: combined inflammation of both antrum and body positively correlated with MAO (CC = 0.29 and 0.38, respectively). Male sex and patient height also positively correlated with acid output. Modelling showed that body combined inflammatory score, body atrophy, age and serum pepsinogen I are independent predictors of acid output (R 2 = 0.62). Conclusion: Combination of body gastritis, body atrophy, age and serum pepsinogen I can be used as predictors of acid-secretory state in populations infected with H pylori.

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“…All inoculations were performed within an hour of biopsy. Specimens were incubated for 5 pylori. "1 2.…”

Section: Validation Studymentioning

confidence: 99%

“…It is known that the link between peptic ulcer and smoking cannot be explained by changes in acid output. 5 The description of the presence of the spiral bacterium H. pylori in the stomach as a regular associate of histological antral gastritis and peptic ulcers led to new ideas about the nature of these problems and their management. [6][7][8] Control of H. pylori by the use of bismuth salts is linked with a lower rate of ulcer relapse after healing than is seen with the acid-lowering drugs.…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking and Helicobacter pylori infection

Bateson

1993

Postgraduate Medical Journal

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Summary:The direct urease test was used in 462 patients with normal upper digestive tracts, 108 with duodenal ulcers and 43 with gastric ulcers who attended for upper digestive endoscopy in a prospective study. There was a strong association between Helicobacterpylori infection and current cigarette smoking in patients with normal endoscopy (49.6% vs 35.5%, P < 0.01). The associations of peptic ulcer both with H. pylon infection and cigarette smoking were also confirmed.

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Cigarette smoking, gastric acidity and peptic ulceration

Cited by 20 publications

References 44 publications

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected withHelicobacter pylori

Cigarette smoking and Helicobacter pylori infection

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