Cigarette Smoking During Pregnancy and the Occurrence of Spontaneous Abortion and Congenital Abnormality

Himmelberger, David U.; Brown, Byron W.; Cohen, Ellis N.

doi:10.1093/oxfordjournals.aje.a112645

Cited by 145 publications

(42 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some recent epidemiological studies have clarified that maternal lifestyles, such as smoking or drinking habits and passive smoking during pregnancy, provoke some congenital anomalies (Jones and Smith, 1973;Himmelberger et al, 1978;Ericson et al, 1979;Kuroki, 1988;Jacobson et al, 1993;Yuan et al, 1994), although there are negative reports (Borlee et al, 1978;Marbury et al, 1983;Pradat, 1992). However, to our knowledge, an association of anal atresia with smoking and/or drinking during pregnancy has not been previously reported.…”

Section: Discussionmentioning

confidence: 83%

Anal atresia: Effect of smoking and drinking habits during pregnancy

1995

View full text Add to dashboard Cite

SummaryUsing data compiled from 216,707 births from the population-based Kanagawa Birth Defects Monitoring Program (KAMP), we conducted a case-control study to evaluate the effect of maternal smoking and/or drinking during pregnancy on the risk of infants' anal atresia in 1989-1994. The frequency of maternal smoking (including passive smoking) and/or maternal drinking during pregnancy among 84 infants with anal atresia was compared with 174 matched controls. The 84 anal atresias include 49 cases of isolated anal atresia and 35 cases of syndromal anal atresia. Our findings suggest that maternal drinking during early pregnancy is associated with an increased risk of isolated anal atresia (OR=4.8, 95~ CI 1.2 to 19.1, p<0.05). A slightly increased trend was also observed in the association of maternal smoking during pregnancy with both in the pooled groups of anal atresia (OR= 1.4, 95 ~ CI 0.5 to 3.6).

show abstract

Section: Discussionmentioning

confidence: 83%

Anal atresia: Effect of smoking and drinking habits during pregnancy

1995

View full text Add to dashboard Cite

show abstract

“…In addition, laboratory animals exposed to cigarette smoke have also exhibited reduced fecundity, as evidenced by reduced litter size and increased resorptions [Izzotti et al 2003;Khan et al 2008], poor embryo quality [Huang et al 2008], low fetal weight [Esposito et al 2008]), and fetal demise [Farkas et al 2006]. Early evidence connecting smoking during pregnancy with the risk of spontaneous miscarriage was controversial, with some groups reporting a positive association [Himmelberger et al 1978;Kline et al 1977] and others reporting no association [Harlap and Shiono 1980]. However, later epidemiological [Chatenoud et al 1998;George et al 2006] and metaanalyses [Augood et al 1998] provided additional data supporting the concept that maternal smoking increased the risk of spontaneous abortion.…”

Section: Smoking and Spontaneous Abortionmentioning

confidence: 99%

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Detmar

Jurisicova

2010

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are released into the environment as a result of incomplete fossil fuel combustion from industrial furnaces, woodburning stoves, and automobile exhaust fumes; however, the primary source of human exposure to these compounds is cigarette smoke. Embryonic and fetal loss after treatment with high doses of PAHs have been well documented in animal studies; however, few studies have addressed the reproductive consequences of long-term, low-level exposure to these chemicals. We previously reported that low doses of PAHs administered to ICR mice over a period of 9 weeks prior to conception resulted in early embryonic resorptions, whereby treated dams lost approximately 50% of their litter. During the course of these studies, we observed greater numbers of infiltrating uterine natural killer (uNK) cells into the placenta of PAH-exposed conceptuses. While exposure to high levels of PAHs has been shown to be immunosuppressive, increasing evidence suggests that chronic, low-dose exposure to PAHs may stimulate immune cells. Thus, we hypothesized that low-dose, chronic PAH exposure in our mouse model is mediating embryonic resorption by hyperstimulating maternal immune cells. In this review of the literature, we outline the rationale of our argument and present preliminary data, focussing upon PAH-mediated alterations in uNK cell dynamics and how these changes may be linked to early embryonic resorptions.

show abstract

“…Reported relative risks of spontaneous abortion among pregnant smokers ranges from 1.1 to 1.8, depending upon the amount of smoking (45,51,81). Reported relative risks for other complications among women who smoke at least one pack of cigarettes a day include 2.0 for placenta previa, 1.8 for abruptio placenta, and 1.6 for bleeding during pregnancy.…”

Section: Major Health Effects Of Prenatal and Postnatal Smokingmentioning

confidence: 99%