Cigarette smoking combined with genetic variation regulates the m6A methylation of CRNKL1 and is associated with bladder cancer risk
Jialei Yang,
Zihan Ji,
Fang Gao
et al.
Abstract:Cigarette smoking was known to accelerate the occurrence and development of bladder cancer by regulating RNA modification. However, the association between the combination of cigarette smoking and RNA modification‐related single nucleotide polymorphisms (RNAm‐SNPs) and bladder cancer risk remains unclear. In this study, 1681 participants, including 580 cases and 1101 controls, were recruited for genetic association analysis. In total, 1 287 990 RNAm‐SNPs involving nine RNA modifications (m6A, m1A, m6Am, 2'‐O‐M… Show more
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