Cigarette Smoking and Testicular Cancer

Srivastava, A. K.; Kreiger, Nancy

doi:10.1158/1055-9965.epi-03-0133

Cited by 26 publications

(16 citation statements)

References 45 publications

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“…Because of its predominant expression in testis, we conclude that testes are also exposed to electrophilic adduct-forming pyrene sulfates by uptake via SOAT. This uptake might even be related to the well known risk of testicular cancer in tobacco smokers (37).…”

Section: Discussionmentioning

confidence: 95%

Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

Geyer

Döring

Meerkamp

et al. 2007

Journal of Biological Chemistry

120

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We have cloned human sodium-dependent organic anion transporter (SOAT) cDNA, which consists of 1502 bp and encodes a 377-amino acid protein. SOAT shows 42% sequence identity to the ileal apical sodium-dependent bile acid transporter ASBT and 33% sequence identity to the hepatic Na ؉ / taurocholate-cotransporting polypeptide NTCP. Immunoprecipitation of a SOAT-FLAG-tagged protein revealed a glycosylated form at 46 kDa that decreased to 42 kDa after PNGase F treatment. SOAT exhibits a seven-transmembrane domain topology with an outside-to-inside orientation of the N-terminal and C-terminal ends. SOAT mRNA is most highly expressed in testis. Relatively high SOAT expression was also detected in placenta and pancreas. We established a stable SOAT-HEK293 cell line that showed sodium-dependent transport of dehydroepiandrosterone sulfate, estrone-3-sulfate, and pregnenolone sulfate with apparent K m values of 28.7, 12.0, and 11.3 M, respectively. Although bile acids, such as taurocholic acid, cholic acid, and chenodeoxycholic acid, were not substrates of SOAT, the sulfoconjugated bile acid taurolithocholic acid-3-sulfate was transported by SOAT-HEK293 cells in a sodium-dependent manner and showed competitive inhibition of SOAT transport with an apparent K i value of 0.24 M. Several nonsteroidal organosulfates also strongly inhibited SOAT, including 1-(-sulfooxyethyl)pyrene, bromosulfophthalein, 2-and 4-sulfooxymethylpyrene, and ␣-naphthylsulfate. Among these inhibitors, 2-and 4-sulfooxymethylpyrene were competitive inhibitors of SOAT, with apparent K i values of 4.3 and 5.5 M, respectively, and they were also transported by SOAT-HEK293 cells.

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Section: Discussionmentioning

confidence: 95%

Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

Geyer

Döring

Meerkamp

et al. 2007

Journal of Biological Chemistry

120

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“…More recent analyses have implicated KITLG, SPRY4, and BAK1 as sporadic testicular cancer susceptibility loci (19). Currently, medical literature does not support an association between alcohol consumption and testicular cancer, however, one previous study offered evidence of an association between smoking and moderate risk of TGCT (20,21). Based on a previous epidemiological analysis, marital status was an independent predictor factor of improved overall survival and cancer-specific survival (22).…”

Section: Discussionmentioning

confidence: 99%

Testicular germ cell tumor: Short and long-term side effects of treatment among survivors

Gil

Sideris

Aoun

et al. 2016

Molecular and Clinical Oncology

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Abstract. Long-term prognosis of germ cell tumor (GCT) types is excellent, however, treatment is associated with non-negligible complication rates and a negative impact on quality of life. The present study described treatment results in terms of survival, both short and long-term toxicity, and paternity rates in a cohort of patients treated at Jules Bordet Institute, University ULB of Brussels (Brussels, Belgium). The present study analyzed the data of a cohort of patients with GCT types. Pre-operative patient and tumor characteristics were described. Performance status, pulmonary function tests and renal clearance prior to chemotherapy were noted. Chemotherapeutic regimens and their associated toxicities were analyzed. The duration to event-free, cancer-specific and overall survivals were estimated using Kaplan-Meier curves. A total of 115 patients (median age, 31-years-old) were treated for a GCT at Jules Bordet Institute. At a median follow-up of 6-years, 11 (10%) patients had relapsed and 2 (2%) developed a second malignant neoplasm. At the final follow-up, 97 (89%) and 6 (5.5%) patients exhibited complete and partial remission, respectively. A total of 6% of patients exhibited a progressive disease. In terms of short-term toxicity, 11% of patients presented with febrile neutropenia. The 10-year overall survival rate and relapse-free survival rate were 93.4 and 89.8%, respectively. The paternity rate post-treatment was 27%. Testicular GCT survivors suffered from short-and long-term treatment-associated side effects on both a physical and psychological level. A long-term close follow-up is necessary in order to assist the patient with these treatment-induced complications.

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“…The only notable association was reported in a recent study that examined duration of smoking and pack-years of smoking and reported significant increased associations of two-to threefold greater for TC in those in the highest exposure categories compared to nonsmokers (Srivastava & Kreiger, 2004). Mechanisms that were suggested to explain a potential association include a direct carcinogenicity of cigarette smoke or a modifying effect of cigarette smoke on sex hormones.…”

Section: Smokingmentioning

confidence: 94%

“…The association between smoking and TC, as with maternal smoking during pregnancy and TC, is inconsistent (Coldman et al, 1982;Gallagher et al, 1995;Henderson et al, 1979;Srivastava & Kreiger, 2004;Thune & Lund, 1994;UKTCSG, 1994a). The only notable association was reported in a recent study that examined duration of smoking and pack-years of smoking and reported significant increased associations of two-to threefold greater for TC in those in the highest exposure categories compared to nonsmokers (Srivastava & Kreiger, 2004).…”

Section: Smokingmentioning

confidence: 99%

Testicular Cancer and Hormonally Active Agents∗

Garner

Turner

Ghadirian

et al. 2008

Journal of Toxicology and Environmental Health, Part B

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Testicular cancer (TC) is a rare form of cancer, accounting for 1% of all new cancer cases in Canadian males. TC is the most common malignancy among young men, aged 25-34 yr old. Over previous decades, the incidence of TC has increased in many Western countries. Countries with a sufficiently long period of cancer registration, such as Denmark, document this trend back to the first half of the 20th century. The etiology of TC remains poorly understood. Most of the established risk factors are likely related to in utero events, including some factors that are purported to be surrogate measures for exposure to endogenous estrogens. The correlation of TC with other testicular abnormalities and with pregnancy factors led to the proposal that these conditions are a constellation of sequelae of impairment of testicular development called testis dysgenesis syndrome. There is some limited evidence suggesting that exposure to pharmacological estrogens may contribute to some cases of TC. There is currently no compelling evidence that exposure to environmental estrogenic or other hormonally active substances is contributing to the rise in TC incidence observed in Western nations over the last several decades; however, this question has not been extensively studied. The (1) rarity of this condition in the population, (2) long lag time between the presumed sensitive period during fetal development and clinical appearance of the condition, and (3) lack of a good animal model to study the progression of the disease have greatly hindered the understanding of environmental influences on TC risk.

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Cigarette Smoking and Testicular Cancer

Abstract: The purpose of this study was to determine the relation between testicular cancer and cigarette smoking.

Cited by 26 publications

References 45 publications

Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

Testicular germ cell tumor: Short and long-term side effects of treatment among survivors

Testicular Cancer and Hormonally Active Agents∗

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