Cigarette Smoking and Cancer of the Mouth, Pharynx, and Larynx

Moore, Condict

doi:10.1001/jama.1971.03190170031005

Cited by 163 publications

(18 citation statements)

References 6 publications

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“…Our observation that late complications were higher among active smokers is consistent with those reported by other authors who have proposed that tobacco smoke may impair wound healing and/or promote radiation injury either as a result of vascular injury or as a direct irritant (19)(20)(21). The effect of tobacco smoke on fibroblast proliferation and migration has also been well documented (22).…”

Section: Discussionsupporting

confidence: 92%

Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

Chen

Vaughan

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

185

145

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Section: Discussionsupporting

confidence: 92%

Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

Chen

Vaughan

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

185

145

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“…In three of these, the intervals of 16,25, and 27 years following exposure before cancer formation (Table 2) is compatible with the latent period often encountered in radiation-induced cancers and is strong evidence that they arose after the original cancer was controlled.…”

Section: Discussionsupporting

confidence: 65%

Separate primary carcinomas of the esophagus and head and neck region in the same patient

Cahan

Castro²,

Rosen

et al. 1976

Cancer

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From 1949 to 1972 at Memorial Sloan-Kettering Cancer Center, 60 patients with primary cancers of both the oral cavity, pharynx, larynx (OPL) and esophagus were studied. I n 15, the cancers occurred synchronously, and in 68% they occurred within 2 years of each other, the longest interval being 27 years. T h e tongue and extrinsic larynx were the most common sites of origin together with the middle third of the esophagus. During the same period, over 7000 patients with OPL and over 1000 patients with esophageal cancers were seen at this institution. The majority of patients had a history of excessive smoking and alcohol intake. Four out of nine who had previous radiation therapy for their OPL cancer developed esophageal cancer within the therapeutic field (three after 16, 25, and 27 years). Thirty percent (18/60) had three primary cancers; one had four, of which two were in the head and neck region. Two patients survived more than 5 years; both also had a third primary cancer of the lung. There are broader implications in this study: multiple primary cancers in general, and this group in particular, give us especially valuable clues as to the oncogenic influence of environmental factors as well as cellular, organ, and also systemic susceptibility. With one cancer, one can anticipate formation in other related organs. This provides an opportunity for early diagnosis, more effective management, and improved survival. The cause and effect relationship of tobacco and alcohol must be emphasized at every opportunity and most particularly to those who have developed one cancer in the oropharyngeal-laryngeal region.Cancer 37935-89, 1976.

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“…Peribronchitic previously described [Iravani, 1971bIravani and van As, 1971]. areas were seen in the nonexposed as well as in the exposed rats.…”

Section: Resultsmentioning

confidence: 68%

Long-Term Effect of Cigarette Smoke on Mucociliary Function in Animals

Iravani

Melville²

1974

Respiration

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Rats and hamsters were exposed to thesmoke of unfiltered cigarettes for prolonged periods. The results indicated that the smoke-exposed animals were smaller than their corresponding control mates. In addition, the exposed animals demonstrated a larger variety of mucociliary abnormalities including zones of ciliary inactivity, disturbance of the coordination of ciliary movement, impaired mucus production and altered rheological characteristics of mucus. The possible relationship to chronic bronchitis is discussed

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Cigarette Smoking and Cancer of the Mouth, Pharynx, and Larynx

Cited by 163 publications

References 6 publications

Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

Separate primary carcinomas of the esophagus and head and neck region in the same patient

Long-Term Effect of Cigarette Smoke on Mucociliary Function in Animals

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