Cigarette smoking and appendectomy: Effect on clinical course of diverticulosis

Usai, Paolo; Ibba, Ivan; Lai, Michela; Boi, Maria Francesca; Savarese, Maria Flavia; Cuomo, Rosario; D’Alia, G; Gemini, S; Diaz, Giacomo; Contu, Paolo

doi:10.1016/j.dld.2010.05.008

Cited by 23 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies reported an additional association of diverticular disease with alcohol consumption, smoking and diabetes. However, we found no significant association between the presence of diverticular disease and these cardiometabolic risk factors (7)(8)(9)33). One explanation may be that our study population appears to be rather health-conscious, and participants with heavy smoking habits or alcohol consumption were scarce.…”

Section: Peery Et Al Found a Preponderance Of Asymptomatic Diverticucontrasting

confidence: 68%

“…Initial results of several large-scale clinical studies using colonoscopy or computed tomography indicate that the prevalence of diverticulosis is still increasing with a substantial set of risk factors promoting the development of diverticular disease (5,8,9). Diverticular disease seems to be associated with various factors such as colonic wall alterations or disordered motility, dietary habits, obesity, smoking and different medication (2,3,6,7). Furthermore, early research indicates a genetic predisposition for the development of diverticular disease (10,11).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Storz¹,

Rothenbacher²,

Rospleszcz

et al. 2018

Eur Radiol

View full text Add to dashboard Cite

show abstract

Section: Peery Et Al Found a Preponderance Of Asymptomatic Diverticucontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Storz¹,

Rothenbacher²,

Rospleszcz

et al. 2018

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…The aim of our present study was to assess the role of genetic variations consistently identified in the three large recent GWAS 10,12,13 for the specific risks for diverticulosis and diverticulitis, respectively. Our results are in line with previous data concerning the association of diverticulosis with age and BMI as risk factors (diverticulosis) [22][23][24] , as well as alcohol consumption 25,26 and smoking status [27][28][29] as risk factors for diverticulitis.…”

Section: Discussionsupporting

confidence: 93%

Common variation in FAM155A is associated with diverticulitis but not diverticulosis

Reichert

Kupčinskas

Schulz

et al. 2020

Sci Rep

View full text Add to dashboard Cite

colonic diverticulosis is a very common condition. Many patients develop diverticulitis or other complications of diverticular disease. Recent genome-wide association studies (GWAS) consistently identified three major genetic susceptibility factors for both conditions, but did not discriminate diverticulititis and diverticulosis in particular due the limitations of registry-based approaches. Here, we aimed to confirm the role of the identified variants for diverticulosis and diverticulitis, respectively, within a well-phenotyped cohort of patients who underwent colonoscopy. Risk variants rs4662344 in Rho GTPase-activating protein 15 (ARHGAP15), rs7609897 in collagen-like tail subunit of asymmetric acetylcholinesterase (COLQ) and rs67153654 in family with sequence similarity 155 A (FAM155A) were genotyped in 1,332 patients. Diverticulosis was assessed by colonoscopy, and diverticulitis by imaging, clinical symptoms and inflammatory markers. Risk of diverticulosis and diverticulitis was analyzed in regression models adjusted for cofactors. Overall, the variant in FAM155A was associated with diverticulitis, but not diverticulosis, when controlling for age, BMI, alcohol consumption, and smoking status (oR adjusted 0.49 [95% CI 0.27-0.89], p = 0.002). Our results contribute to the assessment specific genetic variants identified in GWAS in the predisposition to the development of diverticulitis in patients with diverticulosis. Colonic diverticulosis is a widespread gastrointestinal condition described as formation of diverticula, which are sac-like protrusions of mucosa and submucosa through muscularis externa 1,2. Although diverticulosis is predominantly asymptomatic, many patients develop symptoms 3,4. These manifestations are classified as uncomplicated and complicated diverticular disease (DD), an inflammation of the tissue (diverticulitis) or diverticular bleeding. The prevalence of the disease and its complications is constantly increasing due to the aging populations 5,6. Therefore, the identification of underlying pathobiological mechanisms of the disease is relevant for improving everyday clinical practice. It is hypothesized that environmental factors together with structural alteration of the colonic wall and remodeling of the enteric nervous system are all predisposing components in the development of colonic diverticula 5. In recent years, epidemiological twin data have suggested that genetic factors are another major cofactor in the pathogenesis of DD 7,8. Up to date, there has been relatively little research effort to determine these genes and their sequence variants that are associated with the development of DD 9. Recently an Icelandic study group published a genome-wide association study (GWAS) searching for sequence variants that affect the

show abstract

“…Smokers also had more episodes of recurrent diverticulitis [40]. Two retrospective case-control studies have also found that smoking was significantly more common among cases of complicated diverticular disease than among controls [33,41]. Proposed mechanisms for the relationship between smoking and complicated diverticulitis include alterations in immunity, motility and colon blood flow.…”

Section: Smokingmentioning

confidence: 99%

Lifestyle Factors and the Course of Diverticular Disease

Strate¹

2012

Dig Dis

View full text Add to dashboard Cite

The dramatic increase in the prevalence of diverticular disease after industrialization has led to the belief that diet and lifestyle factors play a significant role in its pathogenesis. Dietary fiber deficiency has received the most attention, although data are limited and conflicting. Two recent cross-sectional studies found no association between fiber intake and diverticulosis, and one found a positive association. However, fiber may improve symptoms associated with uncomplicated diverticulosis and decrease the risk of diverticulitis. Red meat intake may also increase the risk of diverticular symptoms and complications. Contrary to a long-standing belief, a large prospective study found that nuts and corn did not increase the risk of diverticulitis or diverticular bleeding. A number of case-control and prospective studies have found positive associations between obesity and diverticular complications. Central obesity may be particularly important. Vigorous physical activity appears to reduce the risk of diverticulitis and diverticular bleeding. Findings regarding smoking and diverticular complications have been inconsistent, but suggest that smokers are at increased risk for complications, particularly perforation. Alcohol may increase the risk of asymptomatic diverticulosis and diverticulitis. Research is needed to define the role of lifestyle modification in the primary and secondary prevention of diverticulosis and its complications.

show abstract

Cigarette smoking and appendectomy: Effect on clinical course of diverticulosis

Cited by 23 publications

References 35 publications

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Common variation in FAM155A is associated with diverticulitis but not diverticulosis

Lifestyle Factors and the Course of Diverticular Disease

Contact Info

Product

Resources

About