Cigarette Smoke Inhibits Contractile Responses of Isolated Hamster Stomach Strip to Prostaglandin E<sub>2</sub>

Toivonen, Heikki; Uotila, Pekka

doi:10.1111/j.1600-0773.1981.tb01617.x

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…This suggests that A I1 had been taken up by the tissue but the contraction of the smooth muscle was hindered by smoke. This conclusion is supported also by our finding that cigarette smoke inhibits also contractile responses of isolated hamster stomach strips to prostaglandin EZ (Toivonen & Uotila 1981).…”

Section: Discussionsupporting

confidence: 81%

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

Toivonen

Nienstedt

Uotila

1981

Acta Pharmacologica et Toxicologica

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Abstracr:The contractile response of isolated superfused rat colons to angiotensinII was inhibited almost totally when cigarette smoke was in contact with the serosal surface of the colon. Filtration of visible particles from the smoke diminished but did not abolish this inhibitory action. An inhibitory factor was also retained by the filter papers. One inhibitor, which was dissolved in Krebs buffer, behaved like nicotine. Carbon monoxide and dioxide were effective inhibitors but only at higher concentrations than they are present in cigarette smoke. Removal of carbon dioxide from cigarette smoke did not abolish the inhibitory action. Neither of the gases nor nicotine alone could fully mimic the action of cigarette smoke. It is possible that the inhibitory action ofcigarette smoke was due to combined action of these compounds. It is, however, also possible, that cigarette smoke contains still other inhibitory compounds. Cigarette smoke probably had its effect directly on the smooth muscle cells, but activation of inhibitory nerves could not be excluded.

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Section: Discussionsupporting

confidence: 81%

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

Toivonen

Nienstedt

Uotila

1981

Acta Pharmacologica et Toxicologica

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A histological and dynamic study of the gastric region of Discoglossus pictus larvae, cultured with or without thyroxine

Pouyet¹,

Hourdry²,

Mesnard³

1983

J. Exp. Zool.

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The organotypic culture of the gastric region is carried out on premetamorphic Discoglossus pictus larvae. Adding thyroxine to the culture medium provokes various transformations. On the cytological level, the reactions observed, which are variable depending on the cell category concerned, can be divided into two types of phenomena: histolytic and histogenetic. Autophagia linked to lysosome intervention is frequently found among the histolytic processes. Autophagic vacuoles and residual bodies are observed. The gastric lumen is filled with deteriorated cells that probably come from the degeneration of the tadpole epithelium (primary epithelium). The incorporation of tritiated thymidine makes it possible to study the evolution of cell proliferation in the control and in the thyroxinated cultures. After a 1-2 day latency period, possibly due to the adjustment of the tissue to the culture environment, the incorporation of the radioprecursor H3-thymidine into the epithelium and the tunica muscularis of thyroxine-treated gut tissue increased on day 3, reached a maximum on day 5, and then dropped slightly on day 7. In the control cultures H3-thymidine incorporation showed the same pattern but lower levels on the same days. The histolytic phenomena induced by thyroxine in vitro are comparable to those of natural metamorphosis. On the other hand, the histogenetic phenomena are incomplete. Proliferating and transitional phases occur but neoformated (or secondary) epithelium does not replace the degenerated primary epithelium, whatever the culture time.

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Interaction of nicotine and prostaglandins in the cardiovascular system

Wennmalm

1982

Prostaglandins

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Cigarette Smoke Inhibits Contractile Responses of Isolated Hamster Stomach Strip to Prostaglandin E₂

Cited by 5 publications

References 9 publications

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

A histological and dynamic study of the gastric region of Discoglossus pictus larvae, cultured with or without thyroxine

Interaction of nicotine and prostaglandins in the cardiovascular system

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Cigarette Smoke Inhibits Contractile Responses of Isolated Hamster Stomach Strip to Prostaglandin E2

Cited by 5 publications

References 9 publications

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

Cigarette Smoke Inhibits Contractile Responses of Rat Isolated Colon to Angiotensin II

A histological and dynamic study of the gastric region of Discoglossus pictus larvae, cultured with or without thyroxine

Interaction of nicotine and prostaglandins in the cardiovascular system

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Product

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Cigarette Smoke Inhibits Contractile Responses of Isolated Hamster Stomach Strip to Prostaglandin E₂