Cigarette smoke-induced oxidative stress in skeletal muscles of mice

Barreiro, Esther; Puerto‐Nevado, Laura del; Puig-Vilanova, Ester; Pérez-Rial, Sandra; Sánchez, Francisco; Martínez-Galán, Lourdes; Rivera, Stephanie; Gea, Joaquim; González-Mangado, Nicolás; Peces-Barba, Germán

doi:10.1016/j.resp.2012.02.001

Cited by 67 publications

(80 citation statements)

References 39 publications

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“…As expected, smoking caused emphysema (23), reduced food intake (24,25) and lowered body weight (23,(26)(27)(28)(29). While reduced food intake could only partially explain the lowered body weight, as previously reported (24), loss of fat mass (28) and reduced lean mass and body growth also contribute to body weight loss.…”

Section: Discussionsupporting

confidence: 63%

Interaction between Physical Activity and Smoking on Lung, Muscle, and Bone in Mice

Cielen

Maes

Heulens

et al. 2016

Am J Respir Cell Mol Biol

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Physical inactivity is an important contributor to skeletal muscle weakness, osteoporosis and weight loss in chronic obstructive pulmonary disease. However, the effects of physical inactivity, in interaction with smoking, on lung, muscle and bone are poorly understood. To address this issue, male mice were randomly assigned into an active (daily running), moderately inactive (space restriction) or extremely inactive group (space restriction followed by hindlimb suspension to mimic bed rest) during 24 weeks and simultaneously exposed to either cigarette smoke or room air. The effects of different physical activity levels and smoking status and their respective interaction were examined on lung function, body composition, in vitro limb muscle function and bone parameters. Smoking caused emphysema, reduced food intake with subsequent loss of body weight, fat, lean and muscle mass but increased trabecular bone volume. Smoking induced muscle fiber atrophy which did not result in force impairment. Moderate inactivity only affected lung volumes and compliance, whereas extreme inactivity increased lung inflammation, lowered body and fat mass, induced fiber atrophy with soleus muscle dysfunction and reduced exercise capacity and all bone parameters. When combined with smoking, extreme inactivity also aggravated lung inflammation and emphysema, and accelerated body and muscle weight loss. This study shows that extreme inactivity, especially when imposed by absolute rest, accelerates lung damage and inflammation. When combined with smoking, extreme inactivity is deleterious for muscle bulk, bone and lungs. These data highlight that the consequences of physical inactivity during the course of COPD should not be neglected.

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Section: Discussionsupporting

confidence: 63%

Interaction between Physical Activity and Smoking on Lung, Muscle, and Bone in Mice

Cielen

Maes

Heulens

et al. 2016

Am J Respir Cell Mol Biol

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show abstract

“…Under resting and exercise conditions, patients with COPD exhibit higher levels of lipid peroxidation, oxidized glutathione, and protein oxidation and nitration in the blood and limb muscles (167,171,177,201,(217)(218)(219)(220)(221)(222)(223)(224)(225)(226)(227)(228)(229)(230)(231)(232). Interestingly, chronic exposure to cigarette smoke increases several limb muscle oxidative stress markers in healthy smokers (233) and animals (233,234). In the latter models, oxidation of muscle proteins anteceded the pathological features induced by cigarette smoke in the lungs of the animals (233).…”

Section: Oxidative Damage In Copdmentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais¹,

Decramer²,

Casaburi³

et al. 2014

Am J Respir Crit Care Med

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874

1,033

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“…disease, obesity, type II diabetes, neurodegenerative disease, atherosclerosis, asthma, chronic obstructive pulmonary disease, and cancer (15)(16)(17)(18)(19)(20)(21)(22)(23). Notwithstanding, a wide variety of other reactive lipid aldehyde species are formed at appreciable levels in mammalian cells, though the specific effect of these lipids on cellular metabolism is less defined.…”

mentioning

confidence: 99%