Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Bertuccio, Paola; Vecchia, Carlo La; Silverman, Debra T.; Petersen, Gloria M.; Bracci, Paige M.; Negri, Eva; Li, D.; Risch, Harvey A.; Olson, Sara H.; Gallinger, Steven; Miller, Anthony B.; Bueno-de-Mesquita, H. B.; Talamini, Renato; Polesel, Jerry; Ghadirian, Parviz; Baghurst, Peter; Zatoński, Witold; Fontham, Elizabeth T.H.; Bamlet, William R.; Holly, Elizabeth A.; Lucenteforte, Ersilia; Hassan, Manal M.; Yu, Herbert; Kurtz, Robert C.; Cotterchio, Michelle; Su, Junwu; Maisonneuve, Patrick; Duell, Eric J.; Bosetti, Cristina; Boffetta, Paolo

doi:10.1093/annonc/mdq613

Cited by 70 publications

(53 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More recently, the Boffetta-team published a pooled analysis study, where they found no significant association between ST use and pancreatic cancer (Bertuccio et al, 2011). Seen together, these research summaries support an overall conclusion of a low relative risk of any cancer from snus use (Rodu, 2011;Lee, 2011).…”

Section: Perceptions Of Relative Risk Of Disease and Addiction From Cmentioning

confidence: 88%

Perceptions of relative risk of disease and addiction from cigarettes and snus.

Lund¹,

Scheffels²

2014

Psychology of Addictive Behaviors

View full text Add to dashboard Cite

The public is largely unaware of the lower global risk associated with snus compared to that of cigarettes, but little is known of perceptions of relative risks for specific diseases. Inveterate, daily and non-daily smokers' perceptions of the relative snus/cigarette risk of cardiovascular disease, and of cancer of the lung, stomach, and oral cavity, and perceptions among smokers, snus users and dual users of the relative risk of nicotine addiction, was studied in a pooled sample from annual national surveys (2008)(2009)(2010)(2011) performed by Statistics Norway. The total sample included 2661 ever smokers and snus users aged 15-79 years old. 53 per cent were men, and the average age was 46.1 years.Compared to medical consensus, all smoker groups overestimated the relative risks of diseases from snus use, and inveterate smokers overestimated them significantly more than other groups. For all diseases except lung cancer, the majority of smokers thought snus users were running a higher or equal risk. For lung cancer, 22 per cent believed that snus use gave a higher or equal risk. Smokers, snus users and dual users tended to think that snus and cigarettes were equally addictive products, while a somewhat higher proportion of those who had quit both products thought that cigarettes were more addictive. Increased knowledge of the relative health risks might give smokers an incitement to switch to snus, and prompt current dual users to stop smoking completely. Awareness could be improved by tailoring information at targeted groups, for example via the health care system.

show abstract

Section: Perceptions Of Relative Risk Of Disease and Addiction From Cmentioning

confidence: 88%

Perceptions of relative risk of disease and addiction from cigarettes and snus.

Lund¹,

Scheffels²

2014

Psychology of Addictive Behaviors

View full text Add to dashboard Cite

show abstract

“…Cigar smokers have increased risk for various types of cancers including cancers of the lung and upper aerodigestive tract, pancreas and bladder, as well as for coronary heart disease and chronic obstructive pulmonary disease (6)(7)(8)(9)(10)(11)(12). Cigar smoking is also associated with gum disease and tooth loss (7).…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Exposure among U.S. Cigar Smokers: An Analysis of 1999–2012 National Health and Nutrition Examination Survey (NHANES) Data

Chen

Kettermann

Rostron

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Cigar consumption is increasing in the United States, but little information is available about exposure to toxic constituents from cigar smoking.Methods: We conducted a cross-sectional analysis of biomarkers of tobacco exposure among 25,522 participants from the National Health and Nutrition Examination Survey (NHANES, 1999(NHANES, -2012. The biomarkers analyzed were serum cotinine, urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), blood lead, blood cadmium, and urinary arsenic. We calculated geometric mean concentrations for each biomarker by tobacco use category and geometric mean ratios controlling for demographic factors.Results: Cigar smokers had higher cotinine, NNAL, and lead concentrations than nontobacco users. The geometric mean concentration [95% confidence interval (CI)] of cotinine for primary cigar smokers (i.e., current cigar/never cigarette smokers) was 6.2 (4.2-9.2) ng/mL versus 0.045 (0.043-0.048) ng/mL for nontobacco users, and the NNAL concentration was 19.1 (10.6-34.3) pg/mg creatinine for primary cigar smokers versus 1.01 (0.95-1.07) pg/mg creatinine for nontobacco users. Secondary cigar smokers (i.e., current cigar/former cigarette smokers) and dual cigar/cigarette smokers had higher cadmium concentrations than nontobacco users. Cigar smoking was associated with significantly higher concentrations of cotinine, NNAL, cadmium, and lead, after adjusting for demographic factors. Secondary cigar smokers had significantly higher cotinine and NNAL concentrations than primary cigar smokers. The NNAL concentrations in daily cigar smokers were comparable with those in daily cigarette smokers.Conclusions: Cigar smokers have higher concentrations of several toxic and carcinogenic substances than nontobacco users.Impact: Our results are consistent with epidemiologic evidence demonstrating cigar smoking as a cause of disease and premature death. Cancer Epidemiol Biomarkers Prev; 23(12); 2906-15. Ó2014 AACR.

show abstract

“…The scientific literature also supported the fact that smoking cessation can reduce this risk by up to 50%, at all age groups but is particularly important for the prevention of early onset of pancreatic cancer [36]. The cigarette smoke comprises well known sixty carcinogens, that is responsible for the initiation of tumrogenesis [37]. …”

Section: Smokingmentioning

confidence: 96%

Role of Probiotics in Pancreatic Cancer Prevention: The Prospects and Challenges

Singhal¹,

Mukherjee²

2016

ABB

View full text Add to dashboard Cite

Pancreatic cancer is expressed as a disorder of chaos that leads to impairment in biochemical and metabolic physiology of pancreas. It is considered as the most intractable and fatal among all gastrointestinal (GI) cancers. The early occurrence of metastatic spread and the development of intrinsic and acquired resistance during drug treatment limit its prognosis at the right time. The universalized treatment involves surgical resection in which only a minority (<20%) of patients qualify due to advanced stage of disease at the time of diagnosis. Despite the rigorous technological developments in understanding the molecular mechanism of pancreatic cancer, no significant advances in efficacy of chemotherapeutic treatment have been arisen till date and still present challenges to overcome. That leads to the scientists to undergo exhaustive research to find an alternative treatment and increasing focus have been given on the studies of symbiotic relationships between microbiota and host which confers benefits to the host in many key aspects of life and form a synergistic harmony so called "super-organism". The perturbations in the regulatory circuits of the host that control homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and favors carcinogenesis in the pancreas. Research studies speculating convincing evidence that, among the gut microbiota, probiotics have demonstrated their potential role in the prevention of all stages of cancer development, but the critical question has been arisen that Can probiotics be used as preventive targets for pancreatic cancer? Thus, the efforts have been directed towards to summarize the prospective and challenging role of probiotics as preventive approach for pancreatic cancer. Though prospects of probiotics in prevention of pancreatic cancer are being great challenge among research community therefore, more rigorous and well-designed in vitro, animal and clinical studies are required for worthy manifestations.

show abstract

Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Abstract: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.

Cited by 70 publications

References 24 publications

Perceptions of relative risk of disease and addiction from cigarettes and snus.

Perceptions of relative risk of disease and addiction from cigarettes and snus.

Biomarkers of Exposure among U.S. Cigar Smokers: An Analysis of 1999–2012 National Health and Nutrition Examination Survey (NHANES) Data

Role of Probiotics in Pancreatic Cancer Prevention: The Prospects and Challenges

Contact Info

Product

Resources

About