Cien años de la bala mágica del Dr. Ehrlich (1909–2009)

Garcı́a-Sánchez, José Elı́as; García, Enrique; Merino, María Lucila

doi:10.1016/j.eimc.2009.07.009

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…It is believed that the host immune system constantly recognizes and eradicates evolving tumors before the clinical manifestations of tumors appear. With suppression of the immune system, cancer will occur frequently ( 16 ). Fifty years later, Thomas ( 17 ) proposed that low expression of tumor cell antigens or impaired cellular immune function are important factors for the occurrence of tumors, based on a study of the evolutionary mechanism of body cellular immunity.…”

Section: Immunological Pathogenesismentioning

confidence: 99%

Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors

et al. 2023

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Purpose of reviewExtragonadal germ cell tumors (EGCTs) are relatively rare tumors, accounting for 1%–5% of all GCTs. In this review, we summarize the current research progress regarding the pathogenesis, diagnosis, and treatment of EGCTs from an immunology perspective.Recent findingsThe histological origin of EGCTs is related to a gonadal origin, but they are located outside the gonad. They show great variation in morphology and can occur in the cranium, mediastinum, sacrococcygeal bone, and other areas. The pathogenesis of EGCTs is poorly understood, and their differential diagnosis is extensive and challenging. EGCT behavior varies greatly according to patient age, histological subtype, and clinical stage.SummaryThis review provides ideas for the future application of immunology in the fight against such diseases, which is a hot topic currently.

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Section: Immunological Pathogenesismentioning

confidence: 99%

Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors

et al. 2023

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“…Drug resistance occurs before, during, or after administering the treatment (6) The origin of drug resistance is not completely clear, however, we can dated its beginnings with the contributions of the German beginning with the contributions of the German doctor and bacteriologist, Paul Ehrlich, who was awarded the Nobel Prize in medicine in 1908. In addition to his contributions in the discovery of arsphenamine, the first effective medicinal treatment against syphilis, in 1878 he published the theory of selective toxicity, in which Paul Ehrlich mentions that staining is selective of biological tissues, due to specific chemical characteristics of cells and in 1906 he coined the term chemotherapy (7)(8)(9). Later in 1916, the scientist Seinai Akatsu of the Rockefeller Institute published an article entitled "The drug-fastness of spirochetes to arsenic, mercurial, and iodide compounds in vitro ", in which he described the following: "it has been known for some time While in trypanosomiasis, trypanosomes that have survived the first effect of an arsenic germicide, such as atoxyl or arsacetin, offer greater resistance to a subsequent dose of the same drug" , with the latter we can say that knowledge of the effect (10)of drug resistance is more than 100 years old, remembering that the first treatments against different diseases date from the use of medicinal compounds after the contributions of Paul Ehrlich.…”

Section: History Of Resistance To Chemo Pharmaceuticalsmentioning

confidence: 99%

Chemodrug resistance: Cancer’s fight for survival

Alcántara Colin,

Sandoval Cabrera,

Martinez Quintero

et al. 2023

nova

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Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis-tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3,FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence.

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Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present

Hidalgo

2021

Methods in Molecular Biology

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Immunohistochemistry is an extraordinary and extensively used technique whereby antibodies are used to detect antigens in cells within a tissue section. It has numerous applications in medicine, particularly in cancer diagnosis. It was Albert Hewett Coons, Hugh J Creech, Norman Jones, and Ernst Berliner who conceptualized and first implemented the procedure of immunofluorescence in 1941. They used fluorescein isothiocyanate (FITC)-labelled antibodies to localize pneumococcal antigens in infected tissues. Since then, with improvement and development of protein conjugation, enzyme labels have been introduced, such as peroxidase and alkaline phosphatase. The history of immunohistochemistry (IHC) combines physiology, immunology, biochemistry, and the work of various Nobel Prize laureates. From von Behring who was awarded de first Nobel Prize in 1901 for his work on serum therapy to the 1984 Nobel Prize for the discovery of monoclonal antibodies by Milstein, Kohler, and Jerne, IHC is a story of cooperation and collaboration which led to the development of this magnificent technique that is used daily in anatomical pathology laboratories worldwide.

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Cien años de la bala mágica del Dr. Ehrlich (1909–2009)

Cited by 9 publications

References 40 publications

Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors

Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors

Chemodrug resistance: Cancer’s fight for survival

Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present

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