Cidofovir Treatment Of BK-virus Related Hemorrhagic Cystitis Early After Allogeneic Stem Cell Transplantation (HSCT) For Malignant Diseases

Comparison of intravenous or intravesical cidofovir in the treatment of BK polyomavirus‐associated hemorrhagic cystitis following adult allogeneic stem cell transplantation—A systematic review

“…In conclusion, due to heterogeneity of the data, high risk of bias, and small sample sizes, no recommendation for the use of CDV in the treatment of BKPyV-HC in adult allogeneic stem cell transplantation can be made at the moment-for intravenous use as well as intravesical treatment. Additionally, we want to emphasize the nephrotoxicity of intravenous CDV with 9.3% renal failure in this group of patients and even more kinds of renal impairment have been described; only Chu et al reported no renal impairment/toxicity for intravenous CDV 24. Interestingly, no renal toxicity was reported in intravesical CDV.…”

“…The literature search for primary studies yielded 232 results. Finally, 9 studies where considered which included a total of 189 adult patients with BKPyV‐HC after allogeneic stem cell transplantation (Figure ) . We could only identify retrospective studies for this review.…”

“…Finally, 9 studies where considered which included a total of 189 adult patients with BKPyV-HC after allogeneic stem cell transplantation ( Figure 2). 4,6,7,15,[20][21][22][23][24] We could only identify retrospective studies for this review. At the time of this review, no prospective study or a RCT was registered at WHO ICTRP or ClinicalTrials.gov.…”