CIDE proteins and metabolic disorders

Gong, Jingyi; Sun, Zhiqi; Li, Peng

doi:10.1097/mol.0b013e328328d0bb

Cited by 141 publications

(135 citation statements)

References 43 publications

(28 reference statements)

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“…CIDE family proteins (Cidea and Cidec) act as important regulators of lipid storage and lipid metabolism in adipocytes by promoting LD fusion and growth (17). Here, we examined the precise function of individual CIDEs in controlling LD fusion and growth in the liver.…”

Section: Discussionmentioning

confidence: 99%

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Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

et al. 2016

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

“…The expression levels of Plin2, Plin3, and Plin5 are up-regulated in fatty livers (16). CIDE proteins, including Cidea, Cideb, and Cidec (also called Fsp27), are novel LD-associated proteins (17,18). CIDEs play important roles in LD morphology and function.…”

mentioning

confidence: 99%

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

et al. 2016

Journal of Biological Chemistry

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“…Our gene-profiling analysis revealed that the expression of a number of lipogenic genes was significantly reduced in the liver of ROR␣ sg/sg mice. These included Cidec and Cidea, which regulate triglyceride storage, the size of lipid droplets, and lipolysis and which have been reported to be highly induced in hepatic steatosis (17,39,41). In addition, the expression of several genes implicated in the main pathway of triglyceride synthesis (37), including glycerol-3-phosphate acyltransferase (Gpam or Gpat1) and acyl-glycerol-3-phosphate acyltransferase 9 (Agpat9), and Mogat1, which is part of an alternative, less-studied pathway of triglyceride synthesis, was significantly reduced in liver of ROR␣ sg/sg mice.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

Kang¹,

Okamoto²,

Takeda³

et al. 2011

Physiological Genomics

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AM. Transcriptional profiling reveals a role for ROR␣ in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics 43: 818 -828, 2011. First published May 3, 2011 doi:10.1152/physiolgenomics.00206.2010.-Retinoid-related orphan receptor (ROR)␣4 is the major ROR␣ isoform expressed in adipose tissues and liver. In this study we demonstrate that ROR␣-deficient staggerer mice (ROR␣ sg/sg ) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resistance. Gene expression profiling showed that many genes involved in triglyceride synthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels in liver of ROR␣ sg/sg mice. In contrast, overexpression of ROR␣ in mouse hepatoma Hepa1-6 cells significantly increased the expression of genes that were repressed in ROR␣ sg/sg liver, including Sult1b1, Adfp, Cidea, and ApoA4. ChIP and promoter analysis suggested that several of these genes were regulated directly by ROR␣. In addition to reduced lipid accumulation, inflammation was greatly diminished in white adipose tissue (WAT) of ROR␣ sg/sg mice fed with an HFD. The infiltration of macrophages and the expression of many immune response and proinflammatory genes, including those encoding various chemo/cytokines, Toll-like receptors, and TNF signaling proteins, were significantly reduced in ROR␣ sg/sg WAT. Moreover, ROR␣ sg/sg mice fed with an HFD were protected from the development of insulin resistance. ROR␣ sg/sg mice consumed more oxygen and produced more carbon dioxide, suggesting increased energy expenditure in this genotype. Our study indicates that ROR␣ plays a critical role in the regulation of several aspects of metabolic syndrome. Therefore, ROR␣ may provide a novel therapeutic target in the management of obesity and associated metabolic diseases. staggerer mice; obesity; metabolic syndrome; macrophage; insulinresistance; diabetes; retinoid-related orphan receptors OBESITY IS A MAJOR GLOBAL health concern. In the United States alone, 30% of the general population is obese and an estimated 66% of all adults are overweight (40). Obesity is associated with an elevated risk of several pathologies, including Type 2 diabetes, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD), cancer, and airway disease (18,36). The molecular links between obesity and these diseases are beginning to be understood. It is now well recognized that obesity is associated with chronic low-grade inflammation and that inflammatory processes play an important role in obesity and related pathologies (18,44,53). Infiltration of macrophages and various T-lymphocytes in hypertrophic adipose tissues have been considered as important early events in the development of obesity-associated complications (14, 38, 57) and the release of proinflammatory cytokines by adipose tissue plays a key ...

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“…The cell death-inducing DFF45-like effector (CIDE) family, another LD-associated protein family, is comprised of three members: Cidea, Cideb, and Cidec, which is called Fsp27 in rodents (Gong et al, 2009). Among CIDE proteins, Cideb promotes the formation of TG-enriched VLDL particles and provides a molecular insight into VLDL lipidation and maturation in hepatocytes (Ye et al, 2009).…”

Section: Cide Proteinsmentioning

confidence: 99%

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

2012

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CIDE proteins and metabolic disorders

Abstract: CIDE proteins are important regulators of energy homeostasis and are closely linked to the development of metabolic disorders including obesity, diabetes, and liver steatosis. They may serve as potential molecular targets for the screening of therapeutic drugs for these diseases.

Cited by 141 publications

References 43 publications

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

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