Ciclosporin Neurotoxicity Presenting as an Unilateral Foot Drop in a Renal Transplant Patient

Patel, Mohan K.; Rashed, Awad; Mesraoua, Boulenouar; Khaddash, Saleh; Romeh, Saleh Abu

doi:10.1159/000186392

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…There are usually case reports regarding PNP after RT, and femoral neuropathy is the most common type of neuropathy (20,21,22,23,24,25,26,27). However, there was no femoral neuropathy in our patients.…”

Section: Discussioncontrasting

confidence: 50%

Neurological Complications after Renal Transplantation: A Retrospective Clinical Study

Cengiz¹,

Adibelli̇²,

Yakupoğlu³

et al. 2015

Arch Neuropsychiatr

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Section: Discussioncontrasting

confidence: 50%

Neurological Complications after Renal Transplantation: A Retrospective Clinical Study

Cengiz¹,

Adibelli̇²,

Yakupoğlu³

et al. 2015

Arch Neuropsychiatr

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“…It has been suggested that high levels of tacrolimus may contribute to an early onset of neurotoxicity, but can occur with normal levels [2,3]. Unfortunate, our patient did not improve after tacrolimus was replaced by rapamycin.…”

Section: Discussionmentioning

confidence: 55%

“…Unfortunate, our patient did not improve after tacrolimus was replaced by rapamycin. Switching to CIN-free immunosuppression, for example, sirolimus and mycophenolate mofetil, might have been equally or more effective alternative to manage tacrolimusinduced neurotoxicity [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…Neurotoxicity can be a serious complication due to the immunosuppressive regimen after renal transplantation. About 10-30 % of patients who are treated with calcineurin inhibitors (CNIs) develop some form of neurotoxicity such as tremors, paraesthesias, and acute polyneuropathy [2,3]. Several viral infections such as cytomegalovirus (CMV), herpes zoster, herpes simplex, human T-lymphotropic virus-1 (HTLV-I), Poliovirus, Entrovirus, Echovirus, Cocksackie B, Cocksackie A can cause neurological complications in renal transplantation patients [1].…”

Section: Introductionmentioning

confidence: 99%

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BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

et al. 2015

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Neurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. In this report, we present an interesting case of a patient who developed acute axonal motor polyneuropathy in the course of BK virus infection 3 months after kidney transplantation. After BK virus clearence in blood, a significant improvement was noted in her polyneuropathy. In patients with acute axonal motor polyneuropathy after transplantation BK virus-induced polyneuropathy should be excluded.

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Cyclosporine Neurotoxicity

Hauben

1996

Pharmacotherapy

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A comprehensive search of the published literature was undertaken to identify reports providing patient‐specific data relating to adverse neurologic events with cyclosporine. References cited in the articles identified by the search were manually reviewed to ensure that articles were pertinent. Studies and case reports on cyclosporine neurotoxicity in which individualized patient data were provided were included for review and analysis. Information pertaining to all aspects of cyclosporine neurotoxicity, including epidemiology, clinical manifestations, postulated mechanisms, and management implications, was evaluated. Estimates from case series suggest a 0.5–35% frequency of the disorder. Risk factors include supratherapeutic blood concentrations of cyclosporine, and pharmacokinetic and pharmacodynamic drug interactions, hypocholesterolemia, and other metabolic abnormalities. Postulated mechanisms include a vasculopathy based on cyclosporine's effect on endothelial cell synthesis of prostaglandin, and release and uptake of endothelin as well as inhibition of mitochondrial steroid 26‐hydroxylase. Reported adverse events involved all levels of the neuraxis. Associated abnormalities include elevated cerebrospinal fluid protein and pleocytosis, various electroencephalogram abnormalities, and characteristic neuroimaging findings. In most patients these events were reversible with dosage reduction or withdrawal of therapy. Many reports described positive rechallenge, and in rare instances the events regressed despite continuing or reintroducing the drug.

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Ciclosporin Neurotoxicity Presenting as an Unilateral Foot Drop in a Renal Transplant Patient

Cited by 4 publications

References 4 publications

Neurological Complications after Renal Transplantation: A Retrospective Clinical Study

Neurological Complications after Renal Transplantation: A Retrospective Clinical Study

BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

Cyclosporine Neurotoxicity

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