Ciclazindol and mazindol on glucose uptake into human isolated skeletal muscle: no interaction of mazindol with methysergide.

Kirby, M J; Turner, Paul

doi:10.1111/j.1365-2125.1977.tb00762.x

Cited by 10 publications

(2 citation statements)

References 8 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to imipramine, et al, 1977;Kirby & Turner, 1977) is a tetra-ciclazindol antagonizes reserpine-and tetracyclic compound with activities very similar benazine-induced hypothermia in mice, potento those of established tricyclic antidepressants tiates metamphetamine-induced weight loss in 640 Felicity A. Kerr & E. Szabadi rats, and potentiates the noradrenaline-induced pressor response and the electrically induced contractions of the nictitating membrane in cats (Beckett et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.

Kerr¹,

Szabadi²

1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

Twenty‐nine healthy volunteers participated in an experiment lasting for 8 weeks: Phase I (2 weeks)‐pre‐treatment control period; Phase II (4 weeks)‐medication with either ciclazindol hydrochloride (50 mg twice daily), or desipramine hydrochloride (50 mg twice daily) or lactose placebo (twice daily) administered in a single‐blind fashion; Phase II (2 weeks)‐recovery. Experimental sessions took place twice weekly for the photographic assessment of resting pupil diameter, and for the assessment of one of the following pupillary responses: mydriatic response to methoxamine, mydriatic response to tyramine, miotic response to pilocarpine. Resting pupil diameter increased during medication with either ciclazindol or desipramine. Methoxamine‐evoked mydriasis and tyramine‐evoked mydriasis were antagonized by both ciclazindol and desipramine. Pilocarpine‐evoked miosis was potentiated by both ciclazindol and desipramine. The steady‐state plasma levels (mean +/‐ s.e. mean) of the antidepressants were: ciclazindol: 5.90 +/‐ 0.74 microM; desipramine: 0.60 +/‐ 0.17 microM. The antagonism of methoxamine‐evoked mydriasis is likely to reflect the blockade of postsynaptic alpha 1‐adrenoceptors in the iris by the antidepressants, whereas the antagonism of tyramine‐evoked mydriasis may reflect both the blockade of uptake of tyramine into presynaptic adrenergic terminals and the blockade of postsynaptic alpha‐adrenoceptors. There is no immediate explanation for the potentiation of pilocarpine‐evoked miosis by the two antidepressants.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.

Kerr¹,

Szabadi²

1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Mazindol increases glucose uptake into human isolated skeletal muscle (Kirby & Turner, 1976) as does fenfluramine, another well established weight-reducing drug (Kirby, 1974) in contrast to amphetamine which has no such effect (Kirby and Turner, 1974). Kirby and Turner (1977) have shown that ciclazindol, like mazindol, produces a significant concentrationdependent increase in glucose uptake into human skeletal muscle. This may indicate a metabolic mechanism underlying the weight loss in addition to appetite suppression.…”

Section: Introductionmentioning

confidence: 99%

A new weight-reducing drug with novel properties

Wheatley

1982

Postgraduate Medical Journal

View full text Add to dashboard Cite

SummaryCiclazindol, a tetracyclic compound originally de-veloped as an antidepressant, was compared to placebo in a double-blind trial involving 114 individuals who were at least 15 % overweight. Following a one week control period patients were allocated to active or placebo groups by random distribution for a period of 4 weeks and this was followed by a final one-week observation period.The mean weight loss of 47 patients who completed the trial on ciclazindol was 6 95 lbs (3-13 kg) and of 48 patients who completed the trial on placebo it was 5 0 lbs (2 25 kg) a difference which is statistically significant in favour of ciclazindol (P< 0 05).The trial demonstrated a marked placebo effect resulting in loss of weight in these patients, but the drug effect was significantly greater.

show abstract

Influence of ciclazindol on monoamine uptake and CNS function in normal subjects

Ehsanullah

Leighton

et al. 1979

Psychopharmacology

View full text Add to dashboard Cite

The potential antidepressant drug ciclazindol inhibited dopamine uptake into human platelets without affecting 5-hydroxytryptamine uptake as compared with a control. It inhibited the tyramine pressor response less than desipramine after single 50-mg oral doses in 6 healthy volunteers under double-blind conditions. Compared with tandamine in a double-blind placebo-controlled study in nine healthy subjects, ciclazindol 50 mg orally caused no significant anticholinergic effects but reduced appetite according to an analysis of variance. Nonparametric analysis did not confirm the anorectic effect. Previous studies had shown that ciclazindol increased glucose uptake into isolated human skeletal muscle independently of insulin. Overall, ciclazindol resembles the antiobesity drug mazindol in molecular structure and pharmacological effects in man. Interactions with sympathomimetic amines and adrenergic neurone-blocking drugs cannot be excluded on the basis of these studies.

show abstract

Ciclazindol and mazindol on glucose uptake into human isolated skeletal muscle: no interaction of mazindol with methysergide.

Cited by 10 publications

References 8 publications

Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.

Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.

A new weight-reducing drug with novel properties

Influence of ciclazindol on monoamine uptake and CNS function in normal subjects

Contact Info

Product

Resources

About