Cicatrizing enterocolitis

Psychiatric study of a consecutive series of 19 patients with regional ileitis.

“…The question is still very controversial. However, evidence for suspecting that there is a strong relation between the two diseases is found in: (1) their beyond-chance genetic coincidence (Crohn and Yarnis, 1958 ;Sherlock et al, 1963 ;Edwards and Truelove, 1964;McConnell, 1965); (2) the association of both diseases with ankylosing spondylitis (McBride et al, 1963;McConnell, 1965;Acheson, 1965); (3) immunological studies (Phear, 1958;Taylor, 1965;Acheson, 1965); (4) the higher risk in Jews, of approximately the same order of magnitude for both diseases (Acheson, 1960;Acheson and Nefzger, 1963); (5) a number of cases where the condition of the colon suggested that both diseases were present (Lumb, 1951; Porritt and Hunt, 1960); (6) the occurrence of the same complications, including erythema nodosum, pyoderma gangrenosum, arthritis, uveitis, and conjunctivitis; and (7) the many overlapping clinical features of the diseases, so that one is sometimes misdiagnosed for the other (Cooke and Brooke, 1955;Yarnis, 1955;Hendrix, 1964 …”

Ileo-caecal granulomata

“…8) might indicate ulcerative colitis (Watson and Roy, 1960), whereas the submucosal thickening with connective tissue proliferation and lymphoid infiltration, with non-caseating giant-cell systems in the submucosa and in the regional lymph nodes is more suggestive of Crohn's disease. This diagnostic dilemma was initially resolved by employing the term 'cicatrizing entero-colitis' (Lumb, 1951), presumably to indicate that the disease process represented a form intermediate between typical…”