Cicatricial Pemphigoid

Ahmed, A. Razzaque; Hombal, Shiril

doi:10.1111/j.1365-4362.1986.tb04544.x

Cited by 140 publications

(110 citation statements)

References 61 publications

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“…In another study conducted during the same period in Tours, the incidence rate was about one in 1700 pregnancies.40 The latter incidence rate may have been overestimated, especially because of potential recruit¬ ment bias: "high-risk" pregnancies are usually admitted our estimate of 406 to 436 new cases per year in France, however, is large enough to establish BP as the major autoimmune subepidermal bullous disease for future therapeutic trials or epidemiologic studies to the obstetric unit of the university hospital in Tours.40 These estimates are somewhat higher than those previ¬ ously reported: one per 7000 and one per 60 000. [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Because this is the first study attempting to esti¬ mate the incidence rates and distribution of autoim¬ mune subepidermal bullous disorders as a whole (with the exception of dermatitis herpetiformis), no compari¬ son can be made with other areas in other countries. Simi¬ lar studies are needed to confirm the very low incidence rates of rare disorders such as CP or EBA and to discuss the rationale behind sophisticated laboratory investiga¬ tions (such as immunoblotting or immunoelectron mi¬ croscopy) in autoimmune subepidermal bullous dis¬ eases to define a diagnostic strategy.…”

Section: Diagnostic Evaluationsmentioning

confidence: 99%

Incidence and Distribution of Subepidermal Autoimmune Bullous Skin Diseases in Three French Regions

Bernard¹

1995

Arch Dermatol

361

120

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Section: Diagnostic Evaluationsmentioning

confidence: 99%

Incidence and Distribution of Subepidermal Autoimmune Bullous Skin Diseases in Three French Regions

Bernard¹

1995

Arch Dermatol

361

120

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“…Laryngeal involvement is a serious complication observed in fewer than 10% of CP cases. 3,4 Histological and ultrastructural evaluation demonstrate that blistering occurs within the lamina lucida. Immunopathologic studies have demonstrated the presence of in situ anti-basement membrane zone (BMZ) autoantibody antigens.…”

mentioning

confidence: 99%

Anti-Epiligrin Cicatricial Pemphigoid With Antibodies Against the γ2 Subunit of Laminin 5

Nousari¹,

Rencic²,

Hsu³

et al. 1999

Arch Dermatol

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“…Cicatricial pemphigoid (CP) is an autoimmune blistering disease that involves multiple mucous membranes and occasionally the skin (1). The pathogenesis is attributed to the deposition in vivo of an anti-basement membrane antibody and complement leading to blister formation and subsequent progressive subepithelial fibrosis (2).…”

mentioning

confidence: 99%

Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid.

Yunis

Mobini

Yunis

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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Cicatricial pemphigoid (CP) is a chronic autoimmune blistering disease affecting multiple mucous membranes derived from stratified squamous epithelium and occasionally the skin. CP has a wide spectrum of disease manifestations. Patients with oral pemphigoid (OP) have a benign self-limited disease in which pathological changes are restricted to the oral mucosa. On the other hand, patients with ocular cicatricial pemphigoid (OCP), a chronic condition marked with relapses and remissions, have ocular involvement and also perhaps involvement of other mucous membranes. AU clinical subsets are characterized by the presence of a similar antibasement zone autoantibody. The factors that determine the development of one form of CP or the other are not known. In a previous study, we described the asiation between OCP and the DQBI*0301 allele (P = 0.006). In this study, we have analyzed 22 Caucasian patients with OP and their family members for major histocompatibility complex DRB generic, DQA1, and DQBI allele associations by PCR-sequence-speciflc oligonucleotide probe hybridization. The results were compared to those obtained from 17 Cancasian patients with OCP and to control Caucasian alleles and haplotypes. The DQBI*0301 allele frequency was 38.6% in OP, 52.9% in OCP, and 17.8% in controls. Statistically siificant associations were detected between the DQB1*0301 allele and both OP (P = 0.0047) and OCP (P < 0.0001). In addition, DRB1*04 showed a statistically significant association (P = 0.005) with OCP when compared to controls. Analysis of major histocompatibility complex class H haplotypes showed sgfant statistical associations between both OCP and OP and the HLA-DRB1*04, DRB4*0101, DQA1*03, DQB1*0301 haplotype (P < 0.0001 and P = 0.0012, respectively). Our results indicate that DQBJ*0301 is a marker of both oral and ocular forms of CP. The analysis ofthe amino acid sequence oftheDQBl alleles present in both OP and OCP suggested that amino acid residues at position 57 and positions 71-77 may also be markers of CP.Cicatricial pemphigoid (CP) is an autoimmune blistering disease that involves multiple mucous membranes and occasionally the skin (1). The pathogenesis is attributed to the deposition in vivo of an anti-basement membrane antibody and complement leading to blister formation and subsequent progressive subepithelial fibrosis (2). CP has various clinical manifestations. When only the oral mucosa (oral pemphigoid, OP) is involved, the condition is usually benign and selflimited. In contrast, ocular CP (OCP) frequently involves other mucous membranes and has severe clinical manifestations and a chronic course requiring the use of high doses of corticosteroids and immunosuppressive agents to prevent blindness.In previous studies, we showed (3) an association between theDQBl *0301 allele and OCP (P < 0.003; relative risk = 9.6) when compared to a large population of healthy normal Caucasians. In that study, 19 out of 20 OCP patients carried DQ7 (DQBI*0301) (3). In addition, the presence ofHLA DQ7 was not due t...

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Cicatricial Pemphigoid

Cited by 140 publications

References 61 publications

Incidence and Distribution of Subepidermal Autoimmune Bullous Skin Diseases in Three French Regions

Incidence and Distribution of Subepidermal Autoimmune Bullous Skin Diseases in Three French Regions

Anti-Epiligrin Cicatricial Pemphigoid With Antibodies Against the γ2 Subunit of Laminin 5

Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid.

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