Cicatricial pemphigoid. Immunofluorescent studies

Bean, Samuel F.

doi:10.1001/archderm.110.4.552

Cited by 51 publications

(48 citation statements)

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“…Similar autoantibodies reacting with human skin but not with guinea pig esophagus have been found by Bean [1974] in a patient with cicatricial pemphigoid. Whether pemphigus antibodies and the pemphigus-like antibody of our pa tient are directed against different molecules or against different antigenic sites of the same molecule remains to be determined by immunochemical analysis with soluble material.…”

Section: Discussionsupporting

confidence: 67%

Eosinophilic Pustulosis with Pemphigus-Like Antibody

Vakilzadeh¹,

Suter²,

Knop³

et al. 1981

Dermatology

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A 75-year-old male with eosinophilic pustulosis Ofuji complicated by superinfection with Pseudomonas aeruginosa and Proteus mirabilis is described. This is the first case of eosinophilic pustulosis with an antiepidermal antibody. This antibody was directed against the intercellular substance of the lower epidermis and it was detected by direct immunofluorescence in the patient’s normal and lesional skin. As revealed by indirect immunofluorescence the patient’s serum reacted with intercellular substance of human lower epidermis but not with guinea pig esophagus. Possibly the detected autoantibody is not characteristic for eosinophilic pustulosis Ofuji but rather an accompanying feature of this case similar to the antiepidermal antibodies found in patients with drug reactions and burns.

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Section: Discussionsupporting

confidence: 67%

Eosinophilic Pustulosis with Pemphigus-Like Antibody

Vakilzadeh¹,

Suter²,

Knop³

et al. 1981

Dermatology

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“…In the past, circulating antibodies in MMP were rarely detected or were of low titers that did not correlate with disease activity. 41 However, with the use of chemically separated normal human epithelium as substrate, detection rates for circulating autoantibodies in patients with MMP have reported to be between 88 to 100 per cent. 42 Further, recent evidence suggest that serial titers of IgG as well as IgA , detected on salt-split human skin, may correlate with disease activity and severity.…”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Robinson

Wray

2003

Australian Dental Journal

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Desquamative gingivitis is a clinical term to describe red, painful, glazed and friable gingivae which may be a manifestation of some mucocutaneous conditions such as lichen planus or the vesiculobullous disorders. It is important to be aware of this rare clinical entity so as to distinguish desquamative gingivitis from plaque induced gingivitis which is an extremely common condition, easily recognized and treated daily by the dental practitioner. This article gives an overview of desquamative gingivitis, its presentation, the possible causes, diagnosis and treatment. Early recognition of these lesions may prevent delayed diagnosis and inappropriate treatment of potentially serious dermatological diseases.

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“…These resolve by formation of a cicatrix. 56 Direct immunofluorescence examination of mucosal biopsies in CP shows a somewhat broader array of abnormalities than those seen in BP. These include linear deposits of IgG, with or without C'3, in roughly 50% of cases.…”

Section: Subepidermal Immunological Bullous Diseasesmentioning

confidence: 99%

Immunopathology of Nonneoplastic Skin Disease:A Brief Review

et al. 1996

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Although immunohistology is most commonly regarded by general pathologists as a technique that has its greatest application in neoplastic diseases, this conclusion is far from accurate in the the context of dermatopathology. In fact, diagnoses for many inflammatory skin disorders are largely predicated on the results of immunologic analyses. This has been true for more than 25 years.1 ' 2The following presentation will briefly outline the methods used in non-neoplastic immunodermatopathology, with emphasis on reagents or techniques that have been introduced in the recent past. Because of spatial constraints and the easy availability of expansive reviews on several of the individual topics at hand, the following discourse will be confined to a concise and practical review of nonneoplastic immunodermatopathology. In that context, detailed consideration will not be given to clinical findings, conventional histologic features, or pathogenetic mechanisms attending the disorders encompassed here. IMMUNOHISTOLOGIC METHODSSeveral immunohistochemical methods are applicable to inflammatory diseases of the skin, in addition to the traditional peroxidase-antiperoxidase or avidin-biotinperoxidase complex techniques. The most commonly used one is that of direct immunofluorescence (DIF) with a fluorescein isothiocyanate (FITC) label, 2 " 6 but indirect immunofluorescence (IIF) has also attained popularity, using monkey esophagus or human saline-split skin as substrates.3 " 5,7 " 10 In the first of these procedures, a biopsy of lesional skin is submitted promptly in saline, or, if sent

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Cicatricial pemphigoid. Immunofluorescent studies

Cited by 51 publications

References 0 publications

Eosinophilic Pustulosis with Pemphigus-Like Antibody

Eosinophilic Pustulosis with Pemphigus-Like Antibody

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Immunopathology of Nonneoplastic Skin Disease:A Brief Review

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