Cicatricial Pemphigoid: Immunofluorescent Findings

Localized Pemphigoid

“…Direct immunofluorescence studies have shown that, in localized bullous pemphigoid, IgG and C3 are usually deposited linearly at BMZ, as they are in generalized bullous pemphigoid and cicatricial pemphigoid (20). Only in rare instances, however was IgA present linearly at BMZ in addition to IgG and C3 (4,17,18). Indirect immunofluorescence studies showed that circulating anti-BMZ antibody of the IgG class was seen in localized bullous pemphigoid..…”

“…Since Brunsting and Perry (I) first described localized pemphigoid as "benign pemphigoid", some cases of this disorder have been reported (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Direct immunofluorescence studies showed that usually IgG and C3 are deposited at BMZ in localized pemphigoid (6,7,9,11,12,17).…”

“…Direct immunofluorescence studies showed that usually IgG and C3 are deposited at BMZ in localized pemphigoid (6,7,9,11,12,17). Only rarely was IgA also deposited (4,17,18). Indirect immunofluorescence studies showed that circulating anti-BMZ antibody of the IgG class was usually represented (7,II).…”