CIC–NUTM1 sarcoma in an 8‐year‐old female patient with a new fusion: A case report

CIC::NUTM1 sarcoma in a 6‐year‐old male patient arising from the choroid plexus of the lateral ventricle: A case report

“…Focal rhabdoid features can also be present. [4][5][6][7]9 In 14 cases, including ours, focal or even diffuse myxoid stromal changes were present. [4][5][6][7][8][9] CIC::NUTM1 sarcomas tend to show diffuse nuclear staining of the NUT marker.…”

“…1 CIC::NUTM1 fusion is pathognomonic for a small subgroup of CICrearranged sarcomas, which was first described in 2016, 2 and since then further 13 cases have been clinicopathologically reported. [3][4][5][6][7][8][9] This subgroup often occurs in axial location with frequent bone involvement, while central nervous system is affected only rarely with three cases reported in the literature. 5 Herein, we report a case that expands this limited cohort of patients with CIC::NUTM1 sarcoma of the brain.A 6-year-old male without significant medical history was admitted to hospital for headache of the frontal region bilaterally, subfebrile temperature and vomiting.…”

“…Including our case, CIC::NUTM1 sarcomas were described among eight paediatric patients with median age of 6.5 years and mean age of 7.75 years. [4][5][6][7][8][9] Median age of all 14 cases is 15.5 years and mean age is 23 years. [4][5][6][7][8][9] Central nervous system was affected only in three cases described in the literature, and just one of them was restricted to the brain (Table 1).…”

“…[4][5][6][7][8][9] Median age of all 14 cases is 15.5 years and mean age is 23 years. [4][5][6][7][8][9] Central nervous system was affected only in three cases described in the literature, and just one of them was restricted to the brain (Table 1). Our case is the second one restricted to the brain and the first one among the paediatric population.…”

“…Our case is the second one restricted to the brain and the first one among the paediatric population. [4][5][6][7][8][9] CIC::NUTM1 sarcomas are often composed of sheets of round to ovoid cells with atypical nuclei. Focal rhabdoid features can also be present.…”