Chymase in Plasma and Urine Extracellular Vesicles: Novel Biomarkers for Primary Hypertension
Sarfaraz Ahmad,
Gagan Deep,
Henry A Punzi
et al.
Abstract:BACKGROUNDExtracellular vesicles (EVs) have emerged as a promising liquid biopsy for various diseases. For the first time, using plasma and urinary EVs, we assessed the activity of renin-angiotensin system (RAS), a central regulator of renal, cardiac, and vascular physiology, in patients with control (Group I) or uncontrolled (Group II) primary hypertension.METHODSEVs were isolated from 34 patients with history of hypertension, and characterized for size and concentration by nanoparticle tracking analyses, exo… Show more
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