Chutes et identification des facteurs de risques médicamenteux chez le sujet âgé : apport du bilan médicamenteux optimisé à l’entrée d’hospitalisation

Bambina, E.; Mestivier, E.; Berod, T.

doi:10.1016/j.phclin.2016.10.058

Cited by 1 publication

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a very high level of heterogeneity in the way polypharmacy was defined across studies. Firstly, three methods were used to calculate medications: simultaneous use ( n = 15 (16 articles)), 26,28–30,41–43,45,47–49,51,52,55–57 cumulative use ( n = 6), 27,32,34,35,44,54 and mean of daily medications ( n = 3) 36,37,53 . Five out of six studies using the cumulative method had different medication counting periods, ranging from 30 days 34 to 12 months 27,35 .…”

Section: Resultsmentioning

confidence: 99%

“…Sample size varied from 50 26 to 2,997,872 27 individuals (Table 1). Hip fractures was the most studied outcome (n = 16 (17 articles) 26,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] ), followed by all bone fractures (n = 12 27,[44][45][46][47][48][49][50][51][52][53][54] ), upper limb fractures (n = 2 55,56 ), and fragility fractures (n = 1 57 ). In 13 studies, the association between polypharmacy and fractures was not the primary objective.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Polypharmacy Assessment and Prevalencementioning

confidence: 99%

See 2 more Smart Citations

Polypharmacy and risk of fractures in older adults: A systematic review

Gagnon,

Talbot,

Tremblay

et al. 2024

J Evidence Based Medicine

View full text Add to dashboard Cite

BackgroundFractures have serious health consequences in older adults. While some medications are individually associated with increased risk of falls and fractures, it is not clear if this holds true for the use of many medications (polypharmacy). We aimed to identify what is known about the association between polypharmacy and the risk of fractures in adults aged ≥65 and to examine the methods used to study this association.MethodsWe conducted a systematic review with narrative synthesis of studies published up to October 2023 in PubMed, Embase, CINAHL, PsychINFO, Cochrane Library, Web of Science, and the grey literature. Two independent reviewers screened titles, abstracts, and full texts, then performed data extraction and quality assessment.ResultsAmong the 31 studies included, 11 different definitions of polypharmacy were used and were based on three medication counting methods (concurrent use 15/31, cumulative use over a period 6/31, daily average 3/31, and indeterminate 7/31). Overall, polypharmacy was frequent and associated with higher fracture risk. A dose–response relationship between increasing number of medications and increased risk of fractures was observed. However, only seven studies adjusted for major confounders (age, sex, and chronic disease). The quality of the studies ranged from poor to high.ConclusionsPolypharmacy appears to be a relevant modifiable risk factor for fractures in older individuals that can easily be used to identify those at risk. The diversity of medication calculation methods and definitions of polypharmacy highlights the importance of a detailed methodology to understand and compare results.

show abstract