Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up

d'Ersu, E.; Ribi, Camillo; Monney, Pierre; Vincenti, Gabriella; Schwitter, Juerg; Rotman, Sam; Hullin, Roger; Regamey, Julien

doi:10.1016/j.ijcard.2018.02.011

Cited by 9 publications

(10 citation statements)

References 21 publications

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“…Palpitation was the main presenting symptom in only 2 cases, which was due to atrial arrhythmia (atrial fibrillation with rapid ventricular response) in 1 case 30 and ventricular arrhythmia (polymorphic premature ventricular beats) in the other case. 61 …”

Section: Resultsmentioning

confidence: 99%

“…Symptoms of heart failure were controlled with medical therapy, and there was no need for advanced treatment. 61 Of the remaining 8 cases with persistent LV dysfunction, all the patients underwent heart transplantation. Three of them finally expired with sudden death with evidence of EGPA relapse involving the transplanted heart in 2 of them.…”

Section: Resultsmentioning

confidence: 99%

“…Relapse after treatment was reported in 1 case, which was controlled after more intensive immunosuppressive therapy. 61 Eight (12.9%) patients underwent heart transplantation after failure of medical treatment. Mortality was reported for 5 (8.1%) patients: 3 patients died after heart transplantation, 26 1 patient died with severe sepsis after intestinal perforation, 4 and 1 patient due to ventricular fibrillation.…”

Section: Resultsmentioning

confidence: 99%

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Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 62 Case Reports

Pakbaz

2020

JTHC

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Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multi-systemic vasculitis, with cardiac involvement being one of its most serious manifestations. We aimed to systematically review and analyze the limited case reports of EGPA with cardiac involvement. f EGPA with cardiac involvement. Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we performed a systematic literature search for the case reports of EGPA with cardiac involvement in the MEDLINE database from 2011 until 2018. For each case, clinical data including sex, age, clinical presentation, electrocardiographic and cardiac imaging findings, the type of cardiac involvement, the available laboratory data (cardiac biomarkers, white blood cell count, eosinophilic count, erythrocyte sedimentation rate, C-reactive protein, and antineutrophil cytoplasmic antibody positivity), therapeutic regimen, and the outcome of the patients were collected and analyzed. Results: A total number of 62 cases were included. The mean age was 48.29±15.60 years, and 51.6% were male. All the cases were in the active disease state. Cardiac symptoms, electrocardiographic abnormalities, abnormal biomarkers, and abnormal echocardiography were detected in 82.3%, 68.5%, 77.4%, and 96.8%, respectively. Cardiac magnetic resonance was done in 46.8% of the patients, and it was abnormal in all. The most common abnormal findings in echocardiography were systolic left ventricular dysfunction (83.9%) and pericardial effusion (37.1%). The most common type of clinical presentation was clinical heart failure (51.6%). Only 6.5% of the patients presented with tamponade. The overall prognosis was good. Conclusion: Any part of the heart could be involved by EGPA. The results emphasize the necessity of in-depth cardiac evaluation in these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 62 Case Reports

Pakbaz

2020

JTHC

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“…Patients' CRP is increased showing an inflammatory response. However, usually, they are ANCA negative [13].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) Mimicking a Stroke and Acute Coronary Syndrome: A Case Report

Ishaq

Malik

Baig

et al. 2020

Cureus

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Churg-Strauss syndrome (CSS) is a rare disease of multiple organ involvement attributed to asthma, eosinophilia, and vasculitis as a diagnostic criterion. Here we report a case of CSS presenting with left leg weakness and chest pain with a diagnosis of myocarditis and neuropathy. Eosinophilia, history of asthma, peripheral neurological damage led to the diagnosis of CSS. Transthoracic echo showed a full-sized segmental wall motion abnormality with normal CT angiography. He responded well to steroid therapy.

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“…Although it is not part of the diagnostic criteria, cardiac involvement is quite prevalent in EGPA, with a reported prevalence of 66% clinically and 92% at autopsy (14). Cardiac MRI findings of EGPA include reduced left ventricular ejection fraction, myocardial edema (shown as high T2 values), and late gadolinium subendocardial enhancement with or without a left ventricular apical thrombus.…”

Section: Teaching Pointsmentioning

confidence: 99%

Noninfectious Granulomatous Diseases of the Chest

et al. 2020

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Noninfectious Granulomatous Diseases of the ChestGranulomas are pathologically defined as focal aggregations of activated macrophages, Langerhans cells, and lymphocytes. Granulomas form in the lungs when the immune system barricades the substances it perceives as foreign but is unable to remove. Granulomas manifest with numerous imaging appearances in thoracic radiology, and their presence is a nonspecific finding. Granulomatous lung diseases comprise multiple entities with variable clinical manifestations and outcomes. Their imaging findings are rarely specific and can mimic malignancies, often triggering an extensive diagnostic workup. Radiologists must be familiar with the clinical manifestations and imaging findings of these entities to generate appropriate differential diagnoses. This review describes the imaging manifestations of various noninfectious, necrotizing, and nonnecrotizing granulomatous diseases that primarily affect the thorax.©

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Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up

Cited by 9 publications

References 21 publications

Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 62 Case Reports

Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis: A Meta-analysis of 62 Case Reports

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) Mimicking a Stroke and Acute Coronary Syndrome: A Case Report

Noninfectious Granulomatous Diseases of the Chest

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