Chrysotile asbestos in kidney cortex of chronically gavaged rats

Patel-Mandlik, Kusum J.; Millette, James R.

doi:10.1007/bf01059588

Cited by 17 publications

(11 citation statements)

References 25 publications

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“…The number of chrysotile fibers per grid hole followed a Poisson distribution (14); 50 grid holes were examined per sample, thus reducing the probability of a zero count to less than 5%. The detection limit of our analytical technique (13) 5.34 x 103/mg dry weight, whereas that in control samples was 10 or 0.2 x 103/mg dry weight. Fibers were at below detection level in blank grids (prepared to test preparative contamination) and grids prepared from tissue preservative.…”

Section: Introductionmentioning

confidence: 71%

“…Penetration of ingested asbestos fibers through gastrointestinal tract and recovery of migrated fibers in distant tissues have been reported in animal and human studies (6)(7)(8)(9)(10)(11)(12)(13)(17)(18)(19). Contrary to this, other studies (20)(21)(22) indicate that ingested fibers do not penetrate or migrate.…”

Section: Discussionmentioning

confidence: 95%

“…Kidney cortex was selected, since in our past study with baboons, the highest concentration of fibers was found in kidney cortex among ten organs under analysis (12). Selikoff (5) (13). Rats dying of natural causes between ages 0-800 days were grouped into four groups by age ranges at death: namely, 0-200 days, 200-400 days, 400-600 days and 600-800 days.…”

Section: Introductionmentioning

confidence: 99%

“…The mean values of four groups showed bimodal distribution. Fiber lengths and frequency distribution of fiber Classes A, B, C, and D recovered in representative samples from test rats in age groups II, III and IV have been described in tabular and nomogram forms (13).…”

Section: Introductionmentioning

confidence: 99%

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Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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With the use of the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate-range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. The rats were divided into four groups by age: 0-200, 200-400, 400-600 and 600-800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fiber recovery being 5.34 x 103/mg dry weight. Average fiber level in control tissues was 0.23 x 103/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (p < 0.005) than that from test tissues. Test groups showed highly significant differences (p < 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 < p < 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall.

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Section: Introductionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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“…There have been at least 12 animal studies involving rats and baboons (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Five rat studies (4)(5)(6)(7)(8) and two baboon studies (8-10) presented evidence of asbestos penetration of the GI tract and/or migration to various tissues.…”

mentioning

confidence: 99%

Asbestos penetration of the gastrointestinal tract.

Hallenbeck¹

1983

Environ Health Perspect

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Asbestos and kidney cancer: The evidence supports a causal association

Smith

Shearn

Wood

1989

American J Industrial Med

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The role of asbestos in the etiology of lung cancer and of mesothelioma of the pleura and peritoneum has been well documented. The evidence for a causal association between asbestos and other human cancers is not as extensive but suggests that asbestos may be carcinogenic at several different sites. This paper is concerned specifically with a possible causal association between asbestos and human kidney cancer. A review of the evidence to date indicates that only three human studies have sufficient statistical power to detect an excess mortality from kidney cancer among workers exposed to asbestos. All three were occupational cohort studies, and two of these gave strong direct evidence for such an excess; a study of U.S. insulators (kidney cancer SMR = 2.22, 90% CI 1.44-3.30), and a study of U.S. asbestos products company workers (kidney cancer SMR = 2.76, 90% CI 1.29-5.18). The third study, of Italian shipyard workers, reported excess mortality from "cancers of the kidney, urinary bladder, and other urinary organs" (SMR = 1.98, 90% CI 1.42-2.70). Further support for a causal association includes studies finding asbestos fibers in human kidneys and urine, as well as reports of kidney tumors in two animal bioassays. It is concluded that asbestos should be regarded as a probable cause of human kidney cancer.

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Chrysotile asbestos in kidney cortex of chronically gavaged rats

Cited by 17 publications

References 25 publications

Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Asbestos penetration of the gastrointestinal tract.

Asbestos and kidney cancer: The evidence supports a causal association

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