Chrysophyllum cainito leaves are effective against pre-clinical chronic pain models: Analysis of crude extract, fraction and isolated compounds in mice

Meira, Nicole Anzanelo; Rocha, Lilian W.; Silva, Gislaine F. da; Quintal, Zhelmy Martin; Monachè, Franco Delle; Filho, Valdir Cechinel; Quintão, Nara Lins Meira

doi:10.1016/j.jep.2016.02.046

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Treatment with plant-derived compounds may exert neuroprotective effects through enhancing nerve regeneration and functional restoration via suppressing neurological oxidative response, inflammation and apoptosis [66]. Tea-derived L-theanine combined with NEP1-40, a competitive antagonist of Nogo receptor (NgR), significantly promoted neuron regeneration after BPRA, and the possible mechanisms included alleviation of oxidative damage and inflammatory responses at the injury sites and antagonism of myelin inhibition [42].…”

Section: Application Of Compounds From Plantsmentioning

confidence: 99%

Therapeutic strategies for brachial plexus injury

Hong¹,

Chen²,

Wu³

et al. 2021

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Brachial plexus avulsion (BPA), a severe acute peripheral nerve injury in adults, results in total loss of the motor function in the upper limb. Although immediate re-implantation surgery is widely performed to repair this lesion, the motor function cannot be fully restored. The main cause is that the growth velocity of axon is extremely slow in order to re-innervate the target muscles before atrophy develops. Therefore, the survival of spinal motoneurons (MNs) is considered to be a prerequisite for the recovery of motor function. The introduction of survival-proactive agents with anti-oxidative stress and anti-inflammation properties has emerged as a new approach to the motor function recovery following BPA. In the current review, we summarized the treatments of BPA in both mouse and rat models following re-implantation surgery. Furthermore, the pain treatment options following BPA were discussed.

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Section: Application Of Compounds From Plantsmentioning

confidence: 99%

Therapeutic strategies for brachial plexus injury

Hong¹,

Chen²,

Wu³

et al. 2021

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“…Among these, C. oliviforme L. (Satin leaf) and C. cainito L. (Golden leaf tree) are successfully acclimatized in Egypt. The occurrence of triterpenoids and sterols has been reported from the leaves of C. cainito [5,6], besides several polyphenols that were isolated from its edible fruits [7,8]. On the other hand, the chemical composition of C. oliviforme is not, by far, thoroughly identified.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Constituents of Chrysophyllum oliviforme L. Leaf Down-Regulate TGF-β Expression and Ameliorate CCl4-Induced Liver Fibrosis: Evidence from In Vivo and In Silico Studies

et al. 2019

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The prevalence of hepatic diseases globally and in Egypt particularly necessitates an intensive search for natural hepatoprotective candidates. Despite the traditional use of Chrysophyllum oliviforme L. and C. cainito L. leaves in the treatment of certain ailments, evidence-based reports on their bioactivities are limited. In this work, in vivo and in silico studies were conducted to evaluate their methanol extracts potential to alleviate liver damage in CCl4-intoxicated rats, in addition to their antioxidant activity and identifying the molecular mechanisms of their phenolic constituents. The extracts restored the altered total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL), alanine aminotransferase ALT, aspartate aminotransferase AST, total protein, and albumin. Histopathological architecture, DNA fragmentation, and mRNA expression level of TGF-β1 also confirmed the anti-fibrotic activity of the two extracts. The total phenolic content (TPC) in C. oliviforme ethanol extract exceeded that in C. caimito. Additionally, the malondialdehyde (MDA), reduced glutathione (GSH), and total antioxidant capacity (TAC) levels assured the antioxidant potential. Seven phenolics; quercetin, isoquercitrin, myricetin, kaempferol, and caffeic, trans-ferulic, and gallic acids were isolated from the ethanol extract of C. oliviforme. The molecular docking of isolated compounds revealed a low binding energy (kcal/mol with TGF-β1, thus confirming the hepatoprotctive activity of the extracts. In conclusion, the C. oliviforme leaves could be considered as potent safe raw material for the production of herbal formulations to alleviate hepatic toxicity after preclinical safety study.

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