Chrysoeriol: Derivatives, Resources, Biosynthetic Pathway, Bioavailability, and Bioactivities

Boro, Arthi; Shanmugam, Ramya; Sivasangar Latha, Ajith; Rajan, Anand Prem; Al-Dhabi, Naif Abdullah; Mariadhas, Valan Arasu; Arumugam, Vijaya Anand; Balasubramanian, Balamuralikrishnan

doi:10.1007/978-3-030-94753-8_16-1

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Chrysoeriol is established to have a variety of pharmacological functions, including antioxidant [48], anti-inflammatory [71], anticancer [72], antidiabetic [73], antiarthritis [74], antimicrobial [75], antithrombotic [76], antihyperlipidemic [77], and antinociceptive [78] (Table 4), as well as interferes in certain disease-related progression pathways [71]. Human aortic smooth muscle cells; 5 and 10 µM.…”

Section: Pharmacological Functionsmentioning

confidence: 99%

Pharmacological Activities of Lonicerae japonicae flos and Its Derivative—“Chrysoeriol” in Skin Diseases

Law,

Wu,

Jiang

et al. 2024

Molecules

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Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) “Lonicerae japonicae flos” in the dried flower bud or bloomed flower of Lonicera japonica Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and fungal infections, which are temporary or permanent and may be painless or painful. Topical corticosteroids are widely used in Western medicine, but there are some side effects when it is continuously and regularly utilized in a large dosage. Chrysoeriol is a natural active ingredient, nontoxic, and without any adverse reactions in the treatment of dermatological conditions. Methods: Nine electronic databases were searched, including WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without regard to language constraints. The pharmacological activities of chrysoeriol from Lonicerae japonicae flos to fight against skin diseases were explained and evaluated through the literature review of either in vitro or in vivo studies. Results: Chrysoeriol decreased the mRNA levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α. These were transcriptionally regulated by NF-κB and STAT3 to combat skin inflammation. It also showed promising actions in treating many skin ailments including wound healing, depigmentation, photoprotection, and antiaging. Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated.

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