Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice

Fabbro, Lucian Del; Gomes, Marcelo Gomes de; Souza, Leandro Cattelan; Góes, André Rossito; Boeira, Silvana Peterini; Oliveira, Mauro Schneider; Furian, Ana Flávia; Jessé, Cristiano Ricardo

doi:10.1016/j.jneuroim.2019.577007

Cited by 21 publications

(7 citation statements)

References 61 publications

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“…Chrysin (25, 50, and 100 mg/kg) improves cognitive capacity, inflammation, and apoptosis to ameliorate traumatic brain injury (TBI) [ 78 ]. Overall, the literature confirms the health-promoting and therapeutic effects of chrysin that are important in disease therapy, and the effect of this valuable compound on molecular pathways ( Figure 2 ) [ 79 , 80 , 81 , 82 ]. In the next sections, we specifically discuss the role of chrysin in cancer therapy [ 83 , 84 ].…”

Section: Chrysin and Its Pharmacological Activitiesmentioning

confidence: 58%

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

et al. 2020

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Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.

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Section: Chrysin and Its Pharmacological Activitiesmentioning

confidence: 58%

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

et al. 2020

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“…Chrysin is a natural compound found in flowers, such as passion fruit and trumpet flower, and foods such as mushrooms, honey, and propolis. Studies report numerous potent activities related to this compound, such as antiinflammatory, antioxidant, anti-allergic, anti-hypertensive, and anxiolytic (Del Fabbro et al 2019;Veerappan, Malarvili 2019). Therefore, the presence of these compounds may contribute to the hypoglycemic effects demonstrated in the present study.…”

Section: Discussionmentioning

confidence: 99%

Sub-chronic effects of Baccharis dracunculifolia treatment on biochemical, oxidative, and histopathological parameters in diabetic rats

et al. 2022

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Background: Oxidative stress and the mild inflammatory process present in diabetes play a critical role in the pathogenesis of the disease and its comorbidities. This understanding has opened new avenues and targets for developing improved treatments since the risk factors associated with diabetes may be reduced through non-pharmacological interventions. In this sense, plant extracts could be efficient in preventing or assisting these pathological conditions treatment. Methods: Diabetes mellitus was induced in 24 rats, which were allocated in 4 groups: Control (CT), Control+Baccharis (CT-B), Diabetes (DB), and Diabetes+Baccharis (DB-B). For 28 days, the animals of CT-B and DB-B groups were treated, via gavage, with B. dracunculifolia extract at 50 mg.kg-1. Results: The DB group presented higher values than the DB-B group on parameters such as creatinine (26.42%), urea (31.42%), and triglycerides (60.80%). Creatinine and triglycerides values of DB-B group (0.39±0.01 e 75.0±8.4, receptively) were equivalent to the values of CT group (0.32±0.01 e 71.7±5.4) and of CT-B group (0.39±0.01, and 58.8±4.5). The treatment with B. dracunculifolia improved the levels of fasting glucose and response of glucose tolerance (32%), insulin (52,17%) and lipid peroxidation (liver 33.33%, kidney 38.77%) when compared to the DB group. Conclusions: The phenolic compounds and the anti-inflammatory activity of the extract of Baccharis dracunculifolia may be responsible for the hypoglycemic effect observed in the study.

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“…We determined seven potential therapeutic targets for the NIM function of LWDH in this study, and the results are listed in Table . AKT1 and PIK3R1 are important members of the PI3K/Akt signaling pathway, which has been found to play a critical role in many physiological and pathological processes in the central nervous system. − The PI3K/Akt signaling pathway can also affect lymphocyte function, regulate immune defects and immune disorders, , and affect the survival of pancreas islet β cells and insulin secretion. − GSK3B is a serine/threonine protein kinase that can modulate immune diseases such as chronic leukemia and autoimmune diseases, , affect Alzheimer’s disease by suppressing tau protein expression, and regulate thyroid function . MAPK9, an important protein kinase in the MAPK signaling pathway, is involved in regulating neurological diseases like epilepsy and cognitive impairment, immune diseases like leukemia and type 1 diabetes, , and metabolic diseases like nonalcoholic fatty liver disease .…”

Section: Discussionmentioning

confidence: 99%

Insights into the Molecular Mechanisms of Liuwei Dihuang Decoction via Network Pharmacology

Chen

Teng

et al. 2020

Chem. Res. Toxicol.

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The traditional Chinese medicines (TCMs) have been used to treat diseases over a long history, but it is still a great challenge to uncover the underlying mechanisms for their therapeutic effects due to the complexity of their ingredients. Based on a novel network pharmacology-based approach, we explored in this study the potential therapeutic targets of Liuwei Dihuang (LWDH) decoction in its neuroendocrine immunomodulation (NIM) function. We not only collected the known targets of the compounds in LWDH but also predicted the targets for these compounds using the balanced substructure-drug-target networkbased inference (bSDTNBI), which is a target prediction method based on network inferring developed by our laboratory. A "target-(pathway)-target" (TPT) network, in which targets of LWDH were connected by relevant pathways, was constructed and divided into several separate modules with strong internal connections. Then the target module that contributes the most to NIM function was determined through a contribution scoring algorithm. Finally, the targets with the highest contribution score to NIM-related diseases in this target module were recommended as potential therapeutic targets of LWDH.

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Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice

Cited by 21 publications

References 61 publications

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Sub-chronic effects of Baccharis dracunculifolia treatment on biochemical, oxidative, and histopathological parameters in diabetic rats

Insights into the Molecular Mechanisms of Liuwei Dihuang Decoction via Network Pharmacology

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