Chrysin prevents brain damage caused by global cerebralischemia/reperfusion in a C57BL/J6 mouse model

Durak, Mehmet Akif; Öztanır, Mustafa Namık; Türkmen, Neşe Başak; Çiftçi, Osman; Taşlidere, Aslı; Tecellioğlu, Mehmet; Önder, Arif

doi:10.3906/sag-1508-119

Cited by 17 publications

(12 citation statements)

References 27 publications

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“…Chrysin, which we believe has therapeutic power, increased GSH and CAT values in T‐2h/D‐24h + CR group compared to T‐2h/D‐24h group. This result is consistent with the effect of the chrysin in the previous study on CAT and GSH (Durak et al., 2016). AOPP was higher in the torsion/detorsion group than in the control group.…”

Section: Discussionsupporting

confidence: 93%

“…Chrysin application reduced both caspase‐3 and caspase‐8 expression levels in our study. Similarly, it has been reported in the cerebral ischaemia/reperfusion study that chrysin reduces the caspase‐3 expression level (Durak et al., 2016).…”

Section: Discussionsupporting

confidence: 64%

“…It is possible to see similar evidence in the previous study (Yildirim et al, 2018). The healing effect of chrysin on histopathological injury has been reported in the cerebral ischaemia/reperfusion study (Durak et al., 2016). In our study, oedema in intertubular areas was more prominent in T‐2h/D‐24h group.…”

Section: Discussionmentioning

confidence: 79%

“…CR administration was performed half an hour before detorsion. The dose of CR was determined on the basis of reports from previous studies (Durak et al., 2016; Wu et al., 2018; Xu, Shi, & Liu, 2019) Torsion 2 hr/detorsion 24 hr + 50 mg/kg IP CR administrated group (T‐2h/D‐24h + CR group): Treatments were similar to T‐2h/D‐2h + CR group. The only difference is the detorsion time.…”

Section: Methodsmentioning

confidence: 99%

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Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Belhan

Yıldırım

Karasu³

et al. 2020

Andrologia

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After the rotation of the spermatic cord structures around their own axes, testicular torsion occurs due to the deterioration of blood flow in the testicle (Ramachandra, Palazzi, Holmes, & Marietti, 2015). Although it can be seen at any age, it is mostly seen in childhood and puberty (Barada, Weingarten, & Cromie, 1989). Trauma, excessive exercise and contraction of the cremaster muscle may cause torsion in the testes (Shukla, Kelly, Daly, & Guiney, 1982). The ischaemic condition, which is shaped by the duration of torsion, causes necrosis in germinal cells and can even result in infertility (Gezici, Ozturk, Buyukbayram, Ozturk, & Okur, 2006; Wei, Yan, & Zhou, 2011). To prevent this, the achievement of reperfusion by detorsion (to ensure blood flow to the testis) must be done without delay, as delay can cause permanent damage to occur. However, reperfusion causes some complications, even if it shows a healing effect in ischaemic tissue (Akgür, Kilinc, Tanyel, Büyükpamukcu, & Hicsonmez, 1994). Reactive oxygen radicals introduced into the environment after reperfusion lead to lipid peroxidation in cells. This disrupts the permeability of the membrane and leads to loss of cell viability (Sikka, 2004). Many antioxidant agents, such as melatonin, resveratrol, allopurinol, N-acetylcysteine, caffeic acid and coenzyme Q10, have been used with different success rates to minimise the effects of oxidative stress in testicular torsion (Karaguzel, Kadihasanoglu, & Kutlu, 2014). Chrysin, the main component of the herbal medicine known

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

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Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Belhan

Yıldırım

Karasu³

et al. 2020

Andrologia

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“…Oxidative stress and Reactive Oxygen Species (ROS) play key roles in the pathogenesis of I/R injury because they are released during the reperfusion that follows cerebral ischemia. After ischemic attacks, increased lipid peroxidation and decreased enzymatic and or non-enzymatic antioxidants defense causes tissue injury in the brain (Durak et al, 2016;Ma et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Chrysin Mediated by Estrogenic Receptors Following Cerebral Ischemia and Reperfusion in Male Rats

Shooshtari

Farbood

Mansouri

et al. 2021

BCN

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Introduction: Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Neuroprotective strategies were reported to attenuate cognitive deficits after ischemic incidents. Here we studied the neuroprotective potential of chrysin in a rat model of cerebral Ischemia/Reperfusion (I/R) in the presence or absence of Estrogen Receptors (ERs). Methods: Adult male Wistar rats were pretreated with chrysin (CH) (CH; 30 mg/kg; gavage; for 21 consecutive days) alone or with selective ERs antagonists (ERα antagonist MPP; ERβ antagonist PHTPP; IP) or nonselective ERs antagonist (ICI182780; IP). Then, the bilateral common carotid arteries were occluded for 20 min, which was followed by 72 h reperfusion. Subsequently, cognitive performance was evaluated by Morris Water Maze (MWM) and shuttle box tasks, and afterward, their hippocampi were removed for ELISA assays and H&E staining. Oxidative indicators Malondialdehyde (MDA) and Glutathione Peroxidase (GPx), as well as inflammation mediators interleukin (IL)-1β and tumor necrosis factor-alpha (TNFα), were measured using commercial kits. Results: Results of the current study showed that the anti-oxidative and anti-inflammatory properties of CH are possible mechanisms that could improve cognitive deficits and prevent neuronal cell death following I/R (P<0.001). These effects were reversed by ICI182780 (P>0.05). Furthermore, when chrysin was co-treated with ERβ antagonist, PHTPP showed a weak neuroprotective effect in I/R rats. However, these parameters were not significantly different when chrysin was combined with ERα antagonist MPP. Conclusion: Our data confirm that chrysin could potentially serve as a neuroprotective agent against devastating effects of cerebral I/R injury, which may be mediated via its interaction with ERs, especially ERβ.

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Chrysin, an Important Active Ingredient of Honey: Beneficial Pharmacological Activities and Molecular Mechanism of Action

Wali

Jabnoun

Razmpoor

et al. 2020

Therapeutic Applications of Honey and Its Phytochemicals

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Chrysin prevents brain damage caused by global cerebralischemia/reperfusion in a C57BL/J6 mouse model

Abstract: Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.

Cited by 17 publications

References 27 publications

Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Neuroprotective Effects of Chrysin Mediated by Estrogenic Receptors Following Cerebral Ischemia and Reperfusion in Male Rats

Chrysin, an Important Active Ingredient of Honey: Beneficial Pharmacological Activities and Molecular Mechanism of Action

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