Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis

Çomaklı, Selim; Özdemir, Selçuk; Güloğlu, Meryem

doi:10.1016/j.lfs.2023.122096

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…Nab-PTX is mainly metabolized by CYP2C8 in liver microsomes, with < 1% metabolized by the kidneys. According to the pharmacokinetics and pharmacologic toxicity of Nab-PTX[ 18 , 19 ], we speculate that this may be related to oxidative stress, inflammatory response and disruption of the urothelial barrier, especially in patients with a history of cystitis. In conclusion, further research is needed to determine the mechanisms underlying the occurrence and development of hemorrhagic cystitis in patients treated with Nab-PTX.…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic cystitis in gastric cancer after nanoparticle albumin-bound paclitaxel: A case report

Zhang,

Lou

2024

World J Gastrointest Oncol

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BACKGROUND The advanced first-line regimen for advanced gastric cancer is based on a combination of fluoropyrimidine and platinum and/or paclitaxel (PTX), forming a two- or three-drug regimen. Compared to conventional PTX, nanoparticle albumin-bound PTX (Nab-PTX) has better therapeutic effects and fewer adverse effects reported in studies. Nab-PTX is a great option for patients presenting with advanced gastric cancer. Herein, we highlight an adverse event (hemorrhagic cystitis) of Nab-PTX in advanced gastric cancer. CASE SUMMARY A 55-year-old male was diagnosed with lymph node metastasis after a laparoscopic-assisted radical gastrectomy for gastric cancer that was treated by Nab-PTX and S-1 (AS). On the 15th day after treatment with AS, he was diagnosed with hemorrhagic cystitis. CONCLUSION Physicians should be aware that hemorrhagic cystitis is a potential adverse event associated with Nab-PTX treatment.

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Section: Discussionmentioning

confidence: 99%

Hemorrhagic cystitis in gastric cancer after nanoparticle albumin-bound paclitaxel: A case report

Zhang,

Lou

2024

World J Gastrointest Oncol

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“…Notably, a micro-environment with reduced GPX3 expression can accelerate cellular senescence, leading to significant inflammation and severe liver graft injury [ 175 ]. Furthermore, in paclitaxel-induced hepatorenal toxicity in rats, GPX3 expression was significantly downregulated [ 176 ].…”

Section: Research Progress In Gpx3 and Non-neoplastic Diseasesmentioning

confidence: 99%

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Zhang,

Liao,

Lin

et al. 2024

Biomolecules

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Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions in the balance between ROS levels and the body’s antioxidant defenses can lead to the development of numerous diseases. Glutathione peroxidase 3 (GPX3), a key component of the body’s antioxidant system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing the conversion of hydrogen peroxide into water. Beyond its antioxidant function, GPX3 is vital in regulating metabolism, modulating cell growth, inducing apoptosis and facilitating signal transduction. It also serves as a significant tumor suppressor in various cancers. Recent studies have revealed aberrant expression of GPX3 in several non-neoplastic diseases, associating it with multiple pathological processes. This review synthesizes the current understanding of GPX3 expression and regulation, highlighting its extensive roles in noncancerous diseases. Additionally, this paper evaluates the potential of GPX3 as a diagnostic biomarker and explores emerging therapeutic strategies targeting this enzyme, offering potential avenues for future clinical treatment of non-neoplastic conditions.

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Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways

Kankılıç,

Küçükler,

Gür

et al. 2024

J Biochem & Molecular Tox

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Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and its antioxidant properties are at the forefront. This study aims to investigate the protective feature of NRG in PTX‐induced testicular toxicity.Thirty‐five male Sprague rats were divided into five groups: control, NRG, PTX, PTX + NRG50, and PTX + NRG100. Rats were administered PTX (2 mg/kg, BW) intraperitoneally once daily for the first 5 days. Then, between the 6th and 14th days, NRG (50 and 100 mg/kg) was administered orally once a day.NRG reduced PTX‐induced lipid peroxidation and increased testicular tissue antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, and glutathione). While NRG reduces the mRNA expression levels of nuclear factor kappa B, tumor necrosis factor‐alpha, interleukin‐1 beta, cyclooxygenase‐2, interleukin‐6, inducible‐nitric oxide synthase, mitogen‐activated protein kinase 14 (MAPK)14, MAPK15, c‐Jun N‐terminal kinase, P53, Apaf1, Caspase3, Caspase6, Caspase9, and Bax in testicular tissues; it caused an increase in Nrf2, HO‐1, NQO1 and Bcl‐2 levels. NRG also improved the structural and functional integrity of testicular tissue disrupted by PTX. PTX‐induced sperm damage was alleviated by NRG.NRG showed a protective effect by alleviating the PTX‐induced testicular toxicity by increasing oxidative stress, inflammation, apoptosis, and autophagy.

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Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis

Cited by 6 publications

References 60 publications

Hemorrhagic cystitis in gastric cancer after nanoparticle albumin-bound paclitaxel: A case report

Hemorrhagic cystitis in gastric cancer after nanoparticle albumin-bound paclitaxel: A case report

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways

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