Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats

Ahad, Abdul; Ganai, Ajaz Ahmad; Mujeeb, Mohd; Siddiqui, Waseem Ahmad

doi:10.1016/j.taap.2014.05.007

Cited by 114 publications

(84 citation statements)

References 40 publications

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“…In the face of the persistent honey-induced hyperglycemia, the body weight of these patients decreased without diet restrictions, and they did not develop DKA or HHS. The antioxidant [12][13][14], the anti-microbial [15][16][17][18][19], the immune modulator [20] and the anti-inflammatory properties [21][22][23][24] of honey helps also justification for this research.…”

Section: Justification Of the Researchmentioning

confidence: 99%

Honey as a Sole Treatment of Type 2 Diabetes Mellitus

Abdulrhman¹

2016

Endocrinol Metab Syndr

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Objectives: The complications from type 2 diabetes mellitus (DM) still occur despite the ongoing efforts to prevent, or decrease it. This clinical trial aimed to evaluate the effects of honey, as an alternative, non-expensive natural substance in twenty adult patient volunteers suffering from type 2 DM and its associated metabolic derangements. Methods:The patients volunteered to stop the medicines and use honey as a sole treatment of their illnesses. There was no specific dietary restriction except for food preservatives and additives, beverages and sweets.Results: Honey consumption resulted in more hyperglycemia in these patients, but without diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS). Longer-term honey consumption resulted also in weight reduction in all the patients, and control of the blood pressure in the patients, who had hypertension before the honey intervention. The median duration of the honey intervention, without anti-diabetic medicines was 1.09 years, with a range from 0.42 to 13.5 years. Ten of the 20 patients continued the honey intervention for more than 1 year, whereas the other 10 continued the intervention for one year or less. The only cause of the discontinuation of the honey intervention was persistent hyperglycemia. Despite persistent hyperglycemia in all the patients, and persistence of the dyslipidemia in the patients, who had dyslipidemia before the intervention, the macro-vascular complications, particularly the coronary heart disease (CHD), did not develop in any of them. On the contrary, the cardiovascular status improved in the patients, who had CHD before the intervention. However, micro-vascular complications developed in two patient volunteers, who continued the honey intervention, without medicines, for more than 8 years. Conclusion:The author imposed on announcing these results, which might be of help for the patients with diabetes mellitus.

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Section: Justification Of the Researchmentioning

confidence: 99%

Honey as a Sole Treatment of Type 2 Diabetes Mellitus

Abdulrhman¹

2016

Endocrinol Metab Syndr

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“…Various research studies proved that chrysin having anti-oxidant, anti-inflammatory, anti-lipidemic, anxiolytic, anti-apoptotic effect, chemo-preventive effect, anti-hypertensive, anti-diabetic, antiestrogenic, nephro-protective and hepato-protective activity [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJPSR

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Flavonoids are natural products widely distributed in plant kingdom that gained lot of importance due to variety of biological effects relevance to numerous healthcare. It has been chosen as a drug molecule and gained attention in the area of novel drug delivery system because of their disease preventing property and therapeutic expediency in multiple biological effects. Chrysin (C) is one of the most utilized flavonoid having pharmacological effects such as anti-oxidant, antiinflammatory, anti-cancer, antidiabetic and anti hypertensive actions. Even though it has potential therapeutic value and beneficial effects on human health, it possesses some disadvantages like poor solubility and low bio-availability, this limits its therapeutic usage of Chrysin. The present work designed to improve the solubility and the bioavailability of chrysin by the developing a chrysin loaded chitosan nanoparticles (NC). It was prepared by ionic gelation of chitosan and tripolyphosphate. The chrysin loaded chitosan nanoparticles were prepared in 5 batches and named as NC1, NC2, NC3, NC4 and NC5. The formulated nanoparticles were characterized by particle size analyzer, Zeta potential, Scanning Electron Microscopy, transmission Electron microscopy and Fourier transform infrared spectroscopy (FT-IR). The in vitro drug encapsulation efficiency and drug release were performed in the formulated nanoparticle. Among the different batches studied, NC1 batch showed lowest mean particle size and highest entrapment efficiency. Scanning Electron Microscopy of polymeric encapsulated chrysin nanoparticles morphology revealed that spherical in shape. In vitro drug release study showed the chrysin loaded chitosan nanoparticles were capable of releasing drug in sustained manner. It is concluded that, the developed chrysin loaded chitosan nanoparticles might be used as vehicle for the improved solubility and prolonged delivery of chrysin.

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“…The fruit of this plant is commonly used in Thailand and other East Asian countries as food and herbal medicine. Chrysin possesses several biological activities including, anti-cancer (3,4), anti-inflammation (5,6), and antioxidant properties (7,8) and is reported to cause an increase of testosterone production via suppression of aromatase, an enzyme that converts androgen to estrogen (9). However, biological actions are only facilitated given the stable structure and low molecular weights of the active compounds that can be soluble and pass through cell membranes (10).…”

Section: Introductionmentioning

confidence: 99%