Chrysin ameliorates nonalcoholic fatty liver disease in rats

Pai, Sarayu A.; Munshi, Renuka; Panchal, Falguni; Gaur, Ila-Shruti; Juvekar, Archana R.

doi:10.1007/s00210-019-01705-3

Cited by 35 publications

(52 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although NAFLD is now a worldwide health concern, the full pathogenesis leading up to lipid accumulation, cell apoptosis, inflammation, and fibrosis remains ill defined. Many nutri‐based compounds have been assessed for antioxidant properties in the treatment of NAFLD, such as l ‐carnitine (Montesano et al, 2019), chrysin (Pai, Munshi, Panchal, Gaur, & Juvekar, 2019), and plumbagin (Pai et al, 2019). Consequently, many scientists agree that nutrigenomic aspects are very important in the management of NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

Jiao

et al. 2020

British J Pharmacology

View full text Add to dashboard Cite

Background and Purpose Non‐alcoholic fatty liver disease (NAFLD) is considered to be one of the most common chronic liver diseases across worldwide. Astaxanthin (Ax) is a carotenoid, and beneficial effects of astaxanthin, including anti‐oxidative, anti‐inflammatory, and anti‐tumour activity, have been identified. The present study aimed to elucidate the protective effect of astaxanthin against NAFLD and its underlying mechanism. Experimental Approach Mice were fed either a high fat or chow diet, with or without astaxanthin, for up to 12 weeks. L02 cells were treated with free fatty acids combined with different doses of astaxanthin for 48 h. Histopathology, expression of lipid metabolism, inflammation, apoptosis, and fibrosis‐related gene expression were assessed. And the function of mitochondria was also evaluated. Key Results The results indicated that astaxanthin attenuated HFD‐ and FFA‐induced lipid accumulation and its associated oxidative stress, cell apoptosis, inflammation, and fibrosis both in vivo and in vitro. Astaxanthin up‐regulated FGF21 and PGC‐1α expression in damaged hepatocytes, which suggested an unrecognized mechanism of astaxanthin on ameliorating NAFLD. Conclusion and Implications Astaxanthin attenuated hepatocyte damage and mitochondrial dysfunction in NAFLD by up‐regulating FGF21/PGC‐1α pathway. Our results suggest that astaxanthin may become a promising drug to treat or relieve NAFLD.

show abstract

Section: Discussionmentioning

confidence: 99%

Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

Jiao

et al. 2020

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Noteworthy, chrysin can significantly diminish liver weight by reducing hepatic free fatty acids, triglyceride, and cholesterol content. Anti-inflammatory and antioxidant activities of chrysin are also involved in the amelioration of NAFLD via decreasing lobular inflammation, steatosis, and carbonyl content [ 71 ]. Many reports demonstrate that chrysin can be beneficial in reducing acetaminophen-mediated hepatotoxicity in rats.…”

Section: Chrysin and Its Pharmacological Activitiesmentioning

confidence: 99%

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

et al. 2020

View full text Add to dashboard Cite

Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.

show abstract

“…As with NAFLD patients, the golden standard of diagnosis for NAFLD in mice is histological assessment to monitor steatosis. Alternatively, blood biochemical indices such as triglyceride, LDL-C, HDL-C, alanine amino transferase (ALT), and aspartate amino transferase (AST) may be used [109,155,156,159,165,262,302,303]. Recently, an emerging body of evidence indicates that several microRNAs (miRs), including miR-122, are relatively rapid and sensitive blood parameters of NAFLD in rats [304].…”

Section: Diabetic Complicationsmentioning

confidence: 99%

“…Regarding propolis-derived compounds, chrysin has been shown to have anti-NAFLD activity in a rat model [302]. Oral administration of chrysin (25–100 mg/kg/day for 8 weeks) improved fasting glucose, insulin, HOMA-IR, total cholesterol, HDL-C, and non-HDL-C levels of fructose (for 16 weeks) and HFD (8 weeks)-induced NAFLD rats [302].…”

Section: Diabetic Complicationsmentioning

confidence: 99%

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Kitamura

2019

Molecules

View full text Add to dashboard Cite

Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and rats, have some advantages, as genetic and microbiological variables can be controlled. On the other hand, cellular models allow the investigation of detailed molecular events evoked by propolis and derivative compounds. Taking advantage of animal and cellular models, accumulating evidence suggests that propolis extracts have therapeutic effects on obesity by controlling adipogenesis, adipokine secretion, food intake, and energy expenditure. Studies in animal and cellular models have also indicated that propolis modulates oxidative stress, the accumulation of advanced glycation end products (AGEs), and adipose tissue inflammation, all of which contribute to insulin resistance or defects in insulin secretion. Consequently, propolis treatment may mitigate diabetic complications such as nephropathy, retinopathy, foot ulcers, and non-alcoholic fatty liver disease. This review describes the beneficial effects of propolis on metabolic disorders.

show abstract

Chrysin ameliorates nonalcoholic fatty liver disease in rats

Cited by 35 publications

References 52 publications

Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Contact Info

Product

Resources

About