Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties

Medina, Jorge H.; Paladini, Alejandro C.; Wolfman, Claudia; Stein, Miguelina Levi de; Calvo, Daniel J.; Díaz, Luis Eduardo; Peña, Clara

doi:10.1016/0006-2952(90)90716-x

Cited by 172 publications

(105 citation statements)

References 10 publications

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“…When regards hesperetine, authors indicate on its antiallergic, antidepressant and memory improving effect [45,46]. In turn, scutellarin reveals antihypertensive and antivirus [47,48], while chrysin -antitumor, anxiolytic and anticonvulsant activities [49][50][51][52]. Since all listed flavonoids reveal a strong pharmacological activities, they finally may be engaged in the adaptogenic effect of Scutellariae radix.…”

Section: Resultsmentioning

confidence: 99%

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Kosakowska

2017

Herba Polonica

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SummaryIntroduction: Baikal skullcap (Scutellaria baicalensis Georgi) is an important medicinal plant, indigenous to Asia. Due to a wide range of pharmacological activities, its roots has been used for ages in Traditional Chinese Medicine. Recently, the species has become an object of interest of Western medicine, as well. Objective: The aim of the study was to determine the variability of Baikal skullcap population originated from Mongolia and cultivated in Poland, in terms of content and composition of flavonoids in the roots. Methods: The objects of the study were 15 individual plants, selected within examined population and cloned in order to obtain a sufficient amount of raw material. The total content of flavonoids in roots was determined according to Polish Pharmacopeia 6th. The qualitative analysis of flavonoids was carried out using HPLC, Shimadzu chromatograph. Results: The dry mass of roots ranged from 25.88 to 56.14 g × plant-1. The total content of flavonoids (expressed as a quercetin equivalent) varied between 0.17 and 0.52% dry matter (DM). Nine compounds were detected within the group, with oroxylin A 7-Oglucuronide (346.90-1063.00 mg × 100 g-1DM) as a dominant, which differentiated investigated clones at the highest degree (CV=0.27). Baicalin (391.40-942.00 mg × 100 g-1DM), wogonoside (324.00-641.10 mg × 100 g-1DM) and hesperetine 7-O-glucoside (163.00-346.32 mg × 100 g-1DM) were also present in a considerable amounts. Clone 7 was distinguished by the highest content of all investigated compounds, except wogonin and oroxylin A 7-O-glucuronide. Conclusions: Results obtained in present study show a high variability within Baical skullcap investigated population in respect of flavonoid compounds detected in roots. Thus, the results may be used in future investigations concerning the selection and breeding of this species.

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Section: Resultsmentioning

confidence: 99%

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Kosakowska

2017

Herba Polonica

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“…Increasing number of evidence point out the flavonoids as the responsible for the pharmacological effects. Vitexin, isovitexin, orientin, isoorientin (De-Paris et al, 2002) or chrysin (Wolfman et al, 1994;Zanoli, et al, 2000;Medina et al, 1990), have been involved in promoting the CNS effects. Recently, De Paris et al (2002) have shown a correlation between the content of flavonoids found in aqueous extracts from Passiflora species and their psychotropic actions.…”

Section: Discusionmentioning

confidence: 99%

Sedative and anxiolytic effects of methanolic extract from the leaves of Passiflora actinia

Santos

Kurtz

Müller

et al. 2006

Braz. arch. biol. technol.

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“…Amongst these reports flavonoid derivatives with a flavone-like structure such as apigenin [16,17], chrysin [18] and wogonin [19] have been reported for their anxiolytic-like activity in different animal models of anxiety. These flavonoids with BDZ-receptor specificity and/or anxiolytic activity have been isolated from medicinal plants traditionally used in folk medicine for their anxiolytic/sedative properties such as Passiflora coerulea [20], Matricaria recutita [16], Tilia tomentosa [21], Jatropha cilliata [22], Salvia guaranitica [23], Matricaria chamomilla [17], Ziziphus jujuba [24]. Recently, we have reported on the isolation of luteolin-7-O-(2-rhamnosylglucoside) from Passiflora edulis Sims and demonstrated its anxiolytic-like activity [25].…”

Section: Introductionmentioning

confidence: 99%

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

Coleta

Campos

Cotrim

et al. 2008

Behavioural Brain Research

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Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA A receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Luteolin (3 ,4 ,5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon that was reported as devoid of specific affinity for benzodiazepine receptor (BDZ-R) binding site, but its psychopharmacological activity is presently unknown. Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.Luteolin apparently has CNS activity with anxiolytic-like effects despite the low affinity for the BDZ-R shown in vitro. Our findings suggest a possible interaction with other neurotransmitter systems but we cannot rule out the possibility that luteolin's metabolites might show a higher affinity for the BDZ-R in vivo, thus eliciting the evident anxiolytic-like effects through a GABAergic mechanism.

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Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties

Cited by 172 publications

References 10 publications

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Experimental Paper. Intrapopulation variability of flavonoid content in roots of Baikal skullcap (Scutellaria baicalensis Georgi)

Sedative and anxiolytic effects of methanolic extract from the leaves of Passiflora actinia

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

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