Chronotypical characteristics and related miR-142-3p levels of children with attention deficit and hyperactivity disorder

Karadağ, Mehmet; Gökçen, Cem; Nacarkahya, Gülper; Namiduru, Deniz; Dandil, Funda; Çalışgan, Baran; Eroğlu, Secil

doi:10.1016/j.psychres.2018.12.175

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…An animal study reported that miR-142-3p may modulate the BMAL1 gene and regulate circadian functions 36 . Although no direct association was found, peripheral (serum) miR-142-3p was revealed to decrease in patients with attention deficit and hyperactivity disorder with a family history of psychiatric diseases 37 . However, its specificity for BD-II requires further study with other mental disorders.…”

Section: Discussionmentioning

confidence: 79%

Serum miRNA as a possible biomarker in the diagnosis of bipolar II disorder

Lee

Wang

et al. 2020

Sci Rep

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The diagnosis of Bipolar II disorder (BD-II) is currently based on the patients' description of symptoms and clinical behavioral observations. This study explored the possibility of miRNA in peripheral blood (serum) as a specific biomarker for BD-II. We identified 6 candidate miRNAs to differentiate BD-II patients from controls using next-generation sequencing. We then examined these candidate miRNAs using real-time PCR in the first cohort (as training group) of 79 BD-II and 95 controls. A diagnostic model was built based on these candidate miRNAs and then tested on an individual testing group (BD-II: n = 20, controls: n = 20). We found that serum expression levels of miR-7-5p, miR-23b-3p, miR-142-3p, miR-221-5p, and miR-370-3p significantly increased in BD-II compared with controls in the first cohort, whereas that of miR-145-5p showed no significant difference. The diagnostic power of the identified miRNAs was further analyzed using receiver-operating characteristic (ROC). Support vector machine (SVM) measurements revealed that a combination of the significant miRNAs reached good diagnostic accuracy (AUC: 0.907). We further examined an independent testing group and the diagnostic power reached fair for BD-II (specificity = 90%, sensitivity = 85%). We constructed miRNA panels using SVM model, which may aid in the diagnosis for BD-II.Bipolar disorder (BD) has several subtypes. Bipolar I disorder (BD-I) and bipolar II disorder (BD-II) are two of the most commonly seen subtypes of BD. BD-I and BD-II differ in clinical presentation: BD-I involves one or more manic or mixed episodes in addition to one or more major depressive episodes. BD-II is characterised by at least one hypomanic episode with one or more major depressive episodes 1,2 . BD-II has become the focus of increasing attention and has been recognised as a unique disorder. Its prevalence rate ranges from 3% to 11% 3 . Nevertheless, because of the complex spectrum of symptoms, the diagnosis of BD remains subjective. Diagnosing BD is challenging because patients typically regard hypomanic episodes as a positive mood status or experience, and they only seek medical help during depressive episodes 4 . BD is initially misdiagnosed at a rate of approximately 40% and typically requires approximately 5-12 years to be correctly diagnosed and treated appropriately 5,6 . Delayed diagnosis and inefficacious treatment of BD-II may lead to a prolonged course, more affective episodes, and an increased suicide rate, adding further to its socioeconomic burden 5,7 .Accumulating evidence reveals that microribonucleic acids (miRNAs) are involved in many biological processes such as neurogenesis, neuroproliferation, and synaptic plasticity in the central nervous system 8,9 . Different expressions of peripheral miRNA have been reported in several mental disorders including schizophrenia, major depressive disorder, and Alzheimer disease [10][11][12] . Changes in peripheral miRNA may be correlated with changes in neuroendocrine or neuroimmune responses 13 . Because brain tissue ...

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Section: Discussionmentioning

confidence: 79%

Serum miRNA as a possible biomarker in the diagnosis of bipolar II disorder

Lee

Wang

et al. 2020

Sci Rep

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“…[40][41][42] hsa-let-7d-5p 2.03 ±0. 45 1.94 ±0.44 Increased in serum, decreased in WB. [40][41][42] hsa-let-7g-5p 3.23 ±1.…”

Section: Discussionmentioning

confidence: 95%

“…[37] hsa-miR-142-3p 2.13 ±0.37 4.66 ±1.79 Decreased in plasma when presence of psychiatric disease in the family of ADHD-subject. [45] hsa-miR-151a-5p 4.07 ±1.47 2.01 ±0.76 Part of ADHD-prediction model in WBCs. [43] hsa-miR-18a-5p 2.63 ±0.53 2.86 ±0.89 Decreased in WB.…”

Section: Discussionmentioning

confidence: 99%

MiRNA profiles in blood plasma from mother-child duos in human biobanks and the implication of sample quality: Circulating miRNAs as potential early markers of child health

et al. 2020

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BackgroundMicroRNAs (miRNAs) have been linked to several diseases and to regulation of almost every biological process. This together with their stability while freely circulating in blood suggests that they could serve as minimal-invasive biomarkers for a wide range of diseases. Successful miRNA-based biomarker discovery in plasma is dependent on controlling sources of preanalytical variation, such as cellular contamination and hemolysis, as they can be major causes of altered miRNA expression levels. Analysis of plasma quality is therefore a crucial step for the best output when searching for novel miRNA biomarkers. MethodsPlasma quality was assessed by three different methods in samples from mother-child duos (maternal and cord blood, N = 2x38), with collection and storage methods comparable to large cohort study biobanks. Total RNA was isolated and the expression profiles of 201 miR-NAs was obtained by qPCR to identify differentially expressed miRNAs in cord and maternal plasma samples. ConclusionsOur findings suggest that good quality plasma samples suitable for miRNA profiling can be achieved from samples collected and stored by large biobanks. Incorporation of extensive quality control measures, such as those established here, would be beneficial for future projects. The overall low correlation of miRNA expression between cord and maternal samples is an interesting observation, and promising for our future studies on identification of miRNA-based biomarkers in cord blood plasma, considering that these samples were collected at term and some exchange of blood components between cord and maternal blood frequently occur. IntroductionThe finding of circulating microRNAs (miRNA) in body fluids (blood plasma, serum or urine) [1,2] has opened up for the possibility of using blood-based miRNAs as a new approach for diagnostic screening. MiRNAs have been linked to cancer and several other diseases [3], and they have been implicated in promoting neurodevelopmental processes, such as neurogenesis, synapse precursor formation, and synaptic plasticity [4,5]. The stability of miRNAs circulating in blood, and their role as key regulators of almost every biological process, including precise control of neuronal gene expression and thus fine-tuning signaling pathways [6], suggests that they could serve as non-invasive biomarkers for a wide range of diseases [7][8][9], and possibly help explain basic disease etiology. Furthermore, miRNAs have been shown to be targeted by epigenetic modification, and in turn, miRNAs can target regulators of epigenetic pathways [10,11].Blood-based biobanks, which include collection of umbilical cord blood, such as the Mother, Father and Child Cohort Study (MoBa) biobank [12] at the Norwegian Institute of Public Health (NIPH), and other multi-center studies, increasingly incorporate studies identifying candidate mRNA and miRNA expression profile-based biomarkers for a wide range of disorders. The combination of biological specimens and questionnaire data on lifestyle and exposures in MoBa prov...

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“…8 Eveningness preference is associated with many diseases such as attention deficit, addiction, cancer and increased metabolic risk. [9][10][11][12] Due to incompatibilities between biological rhythm and social-environmental factors, disruptions in circadian rhythm are frequent. This condition is called Social jet lag (SJL).…”

Section: Introductionmentioning

confidence: 99%

What is the relationship between obesity and new circadian rhythm parameters in Turkish children and adolescents? A case-control study

Karadağ

Yılmaz

2021

Journal of Pediatric Endocrinology and Metabolism

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Background Although the relationship between circadian rhythm parameters and obesity in children and adolescents is recognized, there are few studies on this topic. The concept of sleep-corrected social jetlag (SJLsc) has been formulated recently, but its relationship with childhood obesity has not yet been established. Therefore, we thought that SJL might play an important role in the etiology of obesity. Accordingly, we aimed to compare circadian rhythm parameters between obese and normal-weight children and adolescents. Methods Seventy-nine obese and eighty-two normal-weight children and adolescents aged between 8 and 17 years participated in this case-control study, which took place in the Mardin province of Turkey. Data were collected with a sociodemographic information form, the Childhood Chronotype Questionnaire, and anthropometric measurements. Results The average ages of the obese participants and controls were 12.3 ± 2.3 and 12.4 ± 2.2 years, respectively. Obese young people had greater evening preference, longer sleep debt duration, SJL duration and SJLsc duration, and higher Morningness–Eveningness Scale (MeScale) scores; and shorter mean sleep duration (p<0.005). In regression analyses, BMI z scores were significantly correlated with all circadian rhythm parameters, except SJLsc duration, while WC z scores were significantly correlated with all circadian rhythm parameters, except mean sleep duration. After adjustment, the high MeScale scores (OR: 1.142, p<0.05) and the presence of psychiatric disorder in the mother (OR: 15.075, p<0.05) were associated with obesity. Conclusions Circadian rhythm parameters can play an important role in the etiology of obesity. Future studies with larger samples and fewer confounding factors are needed to clarify the etiological factors.

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Chronotypical characteristics and related miR-142-3p levels of children with attention deficit and hyperactivity disorder

Cited by 13 publications

References 31 publications

Serum miRNA as a possible biomarker in the diagnosis of bipolar II disorder

Serum miRNA as a possible biomarker in the diagnosis of bipolar II disorder

MiRNA profiles in blood plasma from mother-child duos in human biobanks and the implication of sample quality: Circulating miRNAs as potential early markers of child health

What is the relationship between obesity and new circadian rhythm parameters in Turkish children and adolescents? A case-control study

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