Chronotype and Sleep Quality in Obesity: How Do They Change After Menopause?

Verde, Ludovica; Barrea, Luigi; Vetrani, Claudia; Frías-Toral, Evelyn; Chapela, Sebastián Pablo; Jayawardena, Ranil; Alteriis, Giulia de; Docimo, Annamaria; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna

doi:10.1007/s13679-022-00479-9

Cited by 10 publications

(9 citation statements)

References 95 publications

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“…These include conditions like type 2 diabetes, cardiovascular disorders, and specific cancers such as breast and colon cancer, as well as a reduced overall lifespan [ 2 ]. Moreover, recent evidence suggests that obesity is a risk factor for sleep disorders and reduced sleep quality [ 3 – 5 ]. However, despite all these risks, there are subjects with obesity who do not exhibit metabolic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype

Barrea,

Verde,

Simancas-Racines

et al. 2023

J Transl Med

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Background The terms metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) categorize subjects with obesity based on the presence or absence of cardio-metabolic risk factors. Detecting MUO phenotype is crucial due to the high risk of cardio-metabolic complications, requiring tailored and intensive follow-up. However, diagnosing MUO is time-consuming and costly. Thus, we aimed to investigate the role of Mediterranean diet (MD) in determining MHO/MUO phenotypes and whether adherence to MD could serve as an additional screening tool for MUO phenotype. Methods The study population of this cross-sectional observational study consisted of 275 subjects with obesity. We assessed their lifestyle habits (physical activity and smoking habits), anthropometric measurements (weight, height, waist circumference, body mass index), blood pressure, metabolic parameters, inflammatory marker (high sensitivity C reactive protein levels), adherence to MD (by PREvención con DIetaMEDiterránea (PREDIMED) questionnaire), and MHO/MUO phenotypes. Results The study included 275 individuals with obesity (256F/19M; 34.0 ± 10.5 years; BMI 38.3 ± 5.95 kg/m2). Among them, 114 (41.5%) exhibited MHO phenotype, while 161 (58.5%) had MUO phenotype. MHO phenotype exhibited favorable anthropometric and cardio-metabolic profiles, characterized by lower waist circumference (p < 0.001), BMI (p < 0.001), insulin resistance (p < 0.001), blood pressure (p < 0.001), inflammation (p < 0.001), and lipid levels (p < 0.001) compared to MUO phenotype. Notably, we found that MHO phenotype had higher adherence to MD (p < 0.001) and consumed more extra virgin olive oil (EVOO) (p < 0.001), vegetables (p < 0.001), fruits (p < 0.001), legumes (p = 0.001), fish (p < 0.001), wine (p = 0.008), and nuts (p = 0.001), while reporting lower intake of red/processed meats (p < 0.001), butter, cream, margarine (p = 0.008), soda drinks (p = 0.006), and commercial sweets (p = 0.002) compared to MUO phenotype. Adherence to MD (p < 0.001) and EVOO (p = 0.015) intake were identified as influential factors in determining the presence of MUO/MHO phenotypes. Furthermore, a PREDIMED score < 5 proved to be the most sensitive and specific cut-point value for predicting the presence of MUO phenotype (p < 0.001). Conclusion High adherence to MD was associated with MHO phenotype. Moreover, we suggest that a specific cut-off of the PREDIMED score could be an indicator to discriminate patients with MUO/MHO phenotypes and therefore help in identifying patients at higher cardiovascular risk who will require specific dietary intervention.

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Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype

Barrea,

Verde,

Simancas-Racines

et al. 2023

J Transl Med

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“…Additionally, 40%-60% of menopausal women suffer from insufficient sleep due to hormonal imbalances ( 38 ). This may stem from the fluctuating estrogen levels that disrupt neurotransmitters’ metabolism, leading to sleep disturbances ( 39 ). Furthermore, abnormal levels of estrogen resulting from ovarian failure influence the sleep-wake cycle, causing a decrease in both the frequency and duration of rapid eye movement sleep, consequently contributing to reduced total sleep time ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Association between sleep duration and depression in menopausal women: a population-based study

Zhang,

Cheng

2024

Front. Endocrinol.

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AimsThis research investigated menopausal women older than 50 years to find whether there were any independent relationships between the duration of sleep they got and their prevalence of depression.MethodsNational Health and Nutrition Examination Survey (NHANES) datasets from 2011-2020 were utilized in a cross-sectional study. Using multivariate linear regression models, the linear relationship between sleep duration and depression in menopausal women was investigated. Fitted smoothing curves and thresholds impact evaluation were used to investigate the nonlinear relationship. Then, subgroup analyses were performed according to smoking, drinking alcohol, diabetes, hypertension, heart disease, and moderate activities.ResultsThis population-based study included a total of 3,897 menopausal women (mean age 65.47 ± 9.06 years) aged≥50 years; 3,159 had a depression score <10, and 738 had a depression score≥10. After controlling for all covariates, the prevalence of depression was 17% higher among participants with short sleep duration [OR=1.17, 95%CI=(0.65, 1.70), P<0.0001] and 86% [OR=1.86, 95%CI=(1.05, 2.66), P<0.0001] compared to participants with normal sleep duration. In subgroup analyses stratified by smoking and diabetes, the sleep duration and depression scores of non-smokers [β=-0.18, 95%CI= (-0.33, -0.02), P=0.0241] and diabetics were independently negatively correlated [β=-0.32, 95%CI= (-0.63, -0.01), P=0.0416]. Using a two-segment linear regression model, we discovered a U-shaped relationship between sleep duration and depression scores with an inflection point of 7.5 hours. Less than 7.5 hours of sleep was associated with an increased risk of developing depression [β=-0.81, 95%CI= (-1.05, -0.57), P<0.001]. However, sleeping more than 7.5 hours per night increased the risk of depression considerably [β=0.80, 95%CI= (0.51, 1.08), P<0.001].ConclusionsDepression is associated with sleep duration in menopausal women. Insufficient or excessive sleep may increase the risk of depression in menopausal women.

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“…We have the following conjectures: (1) Sex hormone levels may play an important role. Studies have demonstrated that estrogen has a synergistic effect on the metabolism of sleep-related neurotransmitters, which can shorten sleep latency, and increase the total sleep time and sleep e ciency [24] . The use of sex hormone drugs can signi cantly improve the quality of sleep in postmenopausal women [25] .…”

Section: Discussionmentioning

confidence: 99%

Age at menarche is associated with sleep duration in postmenopausal women: A Nationally Representative Study

Wang

Jiang

Xia

et al. 2023

Preprint

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Background The association between age at menarche (AAM) and sleep duration has been affirmed in some studies. The majority of the subjects, however, were teenagers. Given the prevalence of inadequate sleep duration in postmenopausal women, we undertook this study to investigate the association between AAM and sleep duration in postmenopausal women. Methods The study used data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014. Binary logistic regression models were used to assess the association between the AAM and sleep duration, and a subgroup analysis based on age, diabetes, and hypertension was performed. Results Compared to the group with an AAM < 10 years old, women with later AAM have a greater chance of adequate sleep (AAM between 10 and 12 years old: odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.65–4.41, P < 0.001; AAM between 13 and 15 years old: OR = 2.77, 95%CI: 1.70–4.52, P < 0.001; AAM ≥ 16: OR = 2.23, 95%CI: 1.29–3.85, P = 0.004). After we have made several different multivariate-adjusted models, the above conclusions can still be derived (P < 0.05). In women aged 61 to 71, non-hypertensive patients, and a proportion of patients with diabetes, there is no greater likelihood that other groups will get adequate sleep duration than the reference group (P > 0.05). Conclusions The effect of the AAM on sleep duration has a long-term effect. It is of great significance to avoid early AAM by actively adjusting lifestyle and other methods to prevent the shortening of sleep duration after menopause.

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Chronotype and Sleep Quality in Obesity: How Do They Change After Menopause?

Cited by 10 publications

References 95 publications

Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype

Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype

Association between sleep duration and depression in menopausal women: a population-based study

Age at menarche is associated with sleep duration in postmenopausal women: A Nationally Representative Study

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