Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice

Yaekura, Arisa; Yoshida, Kohsuke; Morii, Kanta; Oketani, Yuto; Okumura, Ikumi; Kaneshiro, Kenta; Shibanuma, Nao; Sakai, Yoshitada; Hashiramoto, Akira

doi:10.1016/j.intimp.2020.106549

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…There is even evidence that leukocyte infiltration to tissues could exhibit its own rhythm (Scheiermann et al, 2013). Furthermore, mice with experimental arthritis showed a significantly decreased arthritis score when given baricitinib, a cytokine blocker, at ZT0 rather than ZT12 (Yaekura et al, 2020). This again highlights the temporal dependency of chronic pain at the behavioral and treatment level.…”

Section: Discussion and Future Directionsmentioning

confidence: 91%

Systems and Circuits Linking Chronic Pain and Circadian Rhythms

2021

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Research over the last 20 years regarding the link between circadian rhythms and chronic pain pathology has suggested interconnected mechanisms that are not fully understood. Strong evidence for a bidirectional relationship between circadian function and pain has been revealed through inflammatory and immune studies as well as neuropathic ones. However, one limitation of many of these studies is a focus on only a few molecules or cell types, often within only one region of the brain or spinal cord, rather than systems-level interactions. To address this, our review will examine the circadian system as a whole, from the intracellular genetic machinery that controls its timing mechanism to its input and output circuits, and how chronic pain, whether inflammatory or neuropathic, may mediate or be driven by changes in these processes. We will investigate how rhythms of circadian clock gene expression and behavior, immune cells, cytokines, chemokines, intracellular signaling, and glial cells affect and are affected by chronic pain in animal models and human pathologies. We will also discuss key areas in both circadian rhythms and chronic pain that are sexually dimorphic. Understanding the overlapping mechanisms and complex interplay between pain and circadian mediators, the various nuclei they affect, and how they differ between sexes, will be crucial to move forward in developing treatments for chronic pain and for determining how and when they will achieve their maximum efficacy.

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Section: Discussion and Future Directionsmentioning

confidence: 91%

Systems and Circuits Linking Chronic Pain and Circadian Rhythms

2021

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“…In collagen-induced arthritis mice models, the diurnal variation in the expression of inflammatory cytokines was observed. Subsequently, the superior effect of baricitinib was observed when the drug was administered in a period (evening) where the cytokine production was the highest (Yaekura et al, 2020). Similarly, diurnal variation of the pro-inflammatory cytokine, IL-6, has been observed in humans (Gudewill et al, 1992).…”

Section: Janus-associated Kinase Inhibitormentioning

confidence: 96%

COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2

2021

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has affected nearly 28 million people in the United States and has caused more than five hundred thousand deaths as of February 21, 2021. As the novel coronavirus continues to take its toll in the United States and all across the globe, particularly among the elderly (>65 years), clinicians and translational researchers are taking a closer look at the nexus of sleep, circadian rhythms and immunity that may contribute toward a more severe coronavirus disease-19 (COVID-19). SARS-CoV-2-induced multi-organ failure affects both central and peripheral organs, causing increased mortality in the elderly. However, whether differences in sleep, circadian rhythms, and immunity between older and younger individuals contribute to the age-related differences in systemic dysregulation of target organs observed in SARS-CoV-2 infection remain largely unknown. Current literature demonstrates the emerging role of sleep, circadian rhythms, and immunity in the development of chronic pulmonary diseases and respiratory infections in human and mouse models. The exact mechanism underlying acute respiratory distress syndrome (ARDS) and other cardiopulmonary complications in elderly patients in combination with associated comorbidities remain unclear. Nevertheless, understanding the critical role of sleep, circadian clock dysfunction in target organs, and immune status of patients with SARS-CoV-2 may provide novel insights into possible therapies. Chronotherapy is an emerging concept that is gaining attention in sleep medicine. Accumulating evidence suggests that nearly half of all physiological functions follow a strict daily rhythm. However, healthcare professionals rarely take implementing timed-administration of drugs into consideration. In this review, we summarize recent findings directly relating to the contributing roles of sleep, circadian rhythms and immune response in modulating infectious disease processes, and integrate chronotherapy in the discussion of the potential drugs that can be repurposed to improve the treatment and management of COVID-19.

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“…Baricitinib is an oral JAK1/JAK2 inhibitor that has been shown to modulate innate and adaptive immune responses by inhibiting the production of inflammatory cytokines including TNF-α, IL-6, IL-17, and IFN-γ 100 and to profoundly reduce inflammation in animal models. 101 It is approved in over 65 countries for the treatment of rheumatoid arthritis. A small pilot study in 12 mild to moderate COVID-19 patients in Italy has suggested that baricitinib in combination with lopinavir/ritonavir may be safe for this study population and can improve clinical and laboratory parameters.…”

Section: Modulators Of Inflammation and Tissue Injurymentioning

confidence: 99%

“…Another class of anti-inflammatory agents that are being studied clinically are JAK inhibitors. Baricitinib is an oral JAK1/JAK2 inhibitor that has been shown to modulate innate and adaptive immune responses by inhibiting the production of inflammatory cytokines including TNF-α, IL-6, IL-17, and IFN-γ and to profoundly reduce inflammation in animal models . It is approved in over 65 countries for the treatment of rheumatoid arthritis.…”

Section: Modulators Of Inflammation and Tissue Injurymentioning

confidence: 99%

Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19

Saul

Einav

2020

ACS Infect. Dis.

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There is a large global unmet need for effective countermeasures to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). The development of novel antiviral drugs is expensive and too slow to meet the immediate need. The repurposing of drugs that are approved or are under advanced clinical investigation provides a cost- and time-effective therapeutic solution. This review summarizes the major repurposed approaches that have been proposed or are already being studied in clinical trials for COVID-19. Among these approaches are drugs that aim to reduce SARS-CoV-2 replication by targeting either viral enzymatic functions or cellular factors required for the viral life cycle. Drugs that modulate the host immune response to SARS-CoV-2 infection by boosting it to enhance viral clearance or by suppressing it to prevent excessive inflammation and tissue injury represent another category. Lastly, we discuss means to discover repurposed drugs and the ongoing challenges associated with the off-label use of existing drugs in the context of the COVID-19 outbreak.

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Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice

Cited by 15 publications

References 32 publications

Systems and Circuits Linking Chronic Pain and Circadian Rhythms

Systems and Circuits Linking Chronic Pain and Circadian Rhythms

COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2

Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19

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