Chronopharmacology of Anti-Convulsive Therapy

Ramgopal, Sriram; Thomé‐Souza, Sigride; Loddenkemper, Tobias

doi:10.1007/s11910-013-0339-2

Cited by 52 publications

(56 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several biological rhythms are thought to influence seizure frequency, including sleep-wake, day/night, circadian, menstrual, and lunar cycles (Ramgopal et al, 2013). Sleep-wake, day/night and circadian cycles are related and often defined ambiguously.…”

Section: Sleep and The Circadian Systemmentioning

confidence: 99%

“…This effect is dependent on the epilepsy syndrome and the location and pathophysiology of the seizure focus (Derry and Duncan, 2013; Ramgopal et al, 2013). NREM sleep has been associated with increased seizure susceptibility, whereas REM sleep is usually regarded as the least seizure-susceptible state.…”

Section: Sleep and The Circadian Systemmentioning

confidence: 99%

“…Profiling individual seizure susceptibility cycles with the use of seizure diaries or ambulatory EEG, could allow for a medication dosing strategy that matches peaks of seizure susceptibility to peaks of serum levels. This strategy, referred to as chronoepileptology (Ramgopal et al, 2013), may also be used in stimulation devices (Loddenkemper et al, 2011). …”

Section: Future Directions: Utilizing Regulatory System Relationshimentioning

confidence: 99%

See 2 more Smart Citations

Seizures and Brain Regulatory Systems

Sedigh-Sarvestani

Blumenfeld

Loddenkemper

et al. 2015

Journal of Clinical Neurophysiology

Self Cite

View full text Add to dashboard Cite

Research into the physiological underpinnings of epilepsy has revealed reciprocal relationships between seizures and the activity of several regulatory systems in the brain, including those governing sleep, consciousness and autonomic functions. This review highlights recent progress in understanding and utilizing the relationships between seizures and the arousal or consciousness system, the sleep-wake and associated circadian system, and the central autonomic network.

show abstract

Section: Sleep and The Circadian Systemmentioning

confidence: 99%

Section: Sleep and The Circadian Systemmentioning

confidence: 99%

Section: Future Directions: Utilizing Regulatory System Relationshimentioning

confidence: 99%

See 1 more Smart Citation

Seizures and Brain Regulatory Systems

Sedigh-Sarvestani

Blumenfeld

Loddenkemper

et al. 2015

Journal of Clinical Neurophysiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…There has been recent interest in the timing of antiepileptic drug regimens based on circadian rhythms [36]. This, as well as other approaches for better seizure detection at nighttime, may help improve patients’ documentation of seizures.…”

Section: Sleep/wake State At Time Of Seizure Onsetmentioning

confidence: 99%

Consciousness of seizures and consciousness during seizures: Are they related?

Detyniecki

Blumenfeld

2014

Epilepsy & Behavior

View full text Add to dashboard Cite

Recent advances have been made in the network mechanisms underlying impairment of consciousness during seizures. However, less is known about patient awareness of their own seizures. Studying patient reports or documentation of their seizures is currently the most commonly utilized mechanism to scientifically measure patient awareness of seizures. The purpose of this review is to summarize the available evidence regarding the accuracy of patient seizure counts and identify the variables that may influence unreliable seizure reporting. Several groups looking at patient documentation of seizures during continuous EEG monitoring show that patients do not report as many as 50% of their seizures. These studies also suggest that seizures accompanied by loss of consciousness, arising from the left hemisphere or the temporal lobe, or occurring during sleep are associated with significantly reduced reporting. Baseline memory performance does not appear to have a major influence on the accuracy of seizure report. Further prospective studies using validated ictal behavioral testing as well as using correlation with newer electrophysiological and neuroimaging techniques for seizure localization are needed to more fully understand the mechanisms of underreporting of seizures. Better methods to alert caregivers about unrecognized seizures and to improve seizure documentation are under investigation. This article is part of a Special Issue entitled Epilepsy and Consciousness.

show abstract

“… The clinical applications of chronopharmacology may lead to improved seizure control in some patients. 46  Circadian regulation is important to maintain normal cellular functions, and a disruption of core clock genes can be damaging to the organism's overall wellbeing 47  Chronopharmaceutics based technology has eliminated the drawbacks associated with the conventional colon specific delivery systems. …”

mentioning

confidence: 99%

Chronotherapeutic Agents: An Overview

Saini¹,

Gupta²

2017

IRJPS

View full text Add to dashboard Cite

ABSTRACT:Circadian and other biological rhythms affect diseases, there symptoms and severity of symptoms and drug therapy can be modified keeping these variations under consideration. Chronopharmacology refers to the manner & extent to which the kinetics and dynamics of medication is directly affected by endogenous biological rhythm and also how the dosing time of medications affects biological timekeeping & features. It has a number of advantages as it reduces drug dosage, increases therapeutic efficacy of drug, limits the time of therapy, reduces side effects, slows down speed of progression of disease and especially helpful in preventing drug toxicity in case of compromised body systems. There is a great deal of interest in how chronotherapy can particularly benefit patients suffering from allergic rhinitis, rheumatoid arthritis and related disorders, asthma, cancer, cardiovascular diseases, ankylosing Spondylitis, renal disorders, antimicrobial therapy, diabetes mellitus, ant-inflammatory therapy, peptic ulcer disease etc. Various drug delivery systems have been developed like pulsatile drug delivery systems, Enteric-coated systems, Layered systems, time-controlled explosion systems (TES), sigmoidal release systems (SRS), electric based drug delivery systems system, controlled-release microchip, etc for effective chronotherapy. There is great deal of hope for effective drug therapy using chronopharmacology in near future.

show abstract

Chronopharmacology of Anti-Convulsive Therapy

Cited by 52 publications

References 103 publications

Seizures and Brain Regulatory Systems

Seizures and Brain Regulatory Systems

Consciousness of seizures and consciousness during seizures: Are they related?

Chronotherapeutic Agents: An Overview

Contact Info

Product

Resources

About