Chronomics, neuroendocrine feedsidewards and the recording and consulting of nowcasts—forecasts of geomagnetics

Abstract

A multi-center four-hourly sampling of many tissues for 7 days (00:00 on April 5-20:00 to April 11, 2004), on rats standardized for 1 month in two rooms on antiphasic lighting regimens happened to start on the day after the second extremum of a moderate double magnetic storm gauged by the planetary geomagnetic Kp index (which at each extremum reached 6.3 international [arbitrary] units) and by an equatorial index Dst falling to -112 and -81 nT, respectively, the latter on the first day of the sampling. Neuroendocrine chronomes (specifically circadian time structures) differed during magnetically affected and quiet days. The circadian melatonin rhythm had a lower MESOR and lower circadian amplitude and tended to advance in acrophase, while the MESOR and amplitude of the hypothalamic circadian melatonin rhythm were higher during the days with the storm. The circadian parameters of circulating corticosterone were more labile during the days including the storm than during the last three quiet days. Feedsidewards within the pineal-hypothalamic-adrenocortical network constitute a mechanism underlying physiological and probably also pathological associations of the brain and heart with magnetic storms. Investigators in many fields can gain from at least recording calendar dates in any publication so that freely available information on geomagnetic, solar and other physical environmental activity can be looked up. In planning studies and before starting, one may gain from consulting forecasts and the highly reliable nowcasts, respectively.

Examination of the interaction of different lighting conditions and chronic mild stress in animal model

“…As a result, sugar intake of animals which were exposed to CMS decreased, they spent more time in REM sleep, and showed more fragmented sleep (16). However, research findings contradict sometimes as stress is not necessarily accompanied by decreased sucrose intake, as it has been confirmed by our earlier findings as well (9,19,28,29,30,31,32).…”

“…Based on the group averages in case of corticosterone the circadian rhythm showed a closely significant level in CMS-exposed groups with altered lighting conditions, while in groups which were not exposed to CMS the circadian rhythm of corticosterone cannot be observed. In case of testosterone, the circadian rhythm could be demonstrated in the CMS-exposed group, while in the group not exposed to CMS and kept between different lighting conditions the circadian effect of the hormone was ended (19,30,32).…”

Chronomics of autism and suicide

“…Melatonin, excretion, has been shown to decrease in association with geomagnetic storms [58,59]. Most recently, the circadian rhythm of pineal melatonin was found to be not only lowered in its average, the MESOR, but also dampened in its predictable extent of change (circadian amplitude) by a magnetic storm [60]. This study also revealed the involvement of hypothalamic melatonin, with an increased MESOR and amplified circadian variation, as well as that of circulating corticosterone, showing a larger day-to-day variability in association with a magnetic storm [60].…”

“…Most recently, the circadian rhythm of pineal melatonin was found to be not only lowered in its average, the MESOR, but also dampened in its predictable extent of change (circadian amplitude) by a magnetic storm [60]. This study also revealed the involvement of hypothalamic melatonin, with an increased MESOR and amplified circadian variation, as well as that of circulating corticosterone, showing a larger day-to-day variability in association with a magnetic storm [60]. Whether these mechanisms and/or a possibly dampened circaseptan rhythm in melatonin [60] are also involved in autism is now a testable hypothesis.…”

Time microscopy for all kinds of data including circadian clock biology

“…The standardization of all circumstances of observation, even under the somewhat controlled conditions of a modem laboratory, with some degree of adjustable temperature, relative humidity and lighting, is not always feasible [1,2] or can be interfered with by disturbance, such as a magnetic storm [3,4]. In many time series, as usually obtained in the clinic or field, rhythms and other time structural elements, such as trends and probabilistic chaos [5] can be further blurred by other variations.…”