Chronomics

Halberg, Franz; Cornélissen, Germaine; Otsuka, Kuniaki; Schwartzkopff, Othild; Halberg, J; Bakken, Earl E.

doi:10.1016/s0753-3322(01)90022-8

Cited by 31 publications

(44 citation statements)

References 45 publications

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“…The cosinor rhythmometry method (Halberg et al, 2001;Nelson et al, 1979) was used to assess circadian rhythms from daily time series of slow-wave activity (SWA), RA, and CBT. The following rhythm characteristics were determined using MATLAB custom applications: rhythm-adjusted mean or MESOR (Midline Estimating Statistic of Rhythm); amplitude, i.e., the difference between the maximum and the MESOR of the fitted curve; and acrophase, which is the lag from a defined reference point, i.e., midnight in the present study (Cugini, 1993).…”

Section: Cosinor Rhythmometrymentioning

confidence: 99%

Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat

Etet

Palomba

Colavito

et al. 2012

Chronobiology International

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Human African trypanosomiasis (HAT), or sleeping sickness, is a severe disease caused by Trypanosoma brucei (T.b.). The disease hallmark is sleep alterations. Brain involvement in HAT is a crucial pathogenetic step for disease diagnosis and therapy. In this study, a rat model of African trypanosomiasis was used to assess changes of sleep-wake, rest-activity, and body temperature rhythms in the time window previously shown as crucial for brain parenchyma invasion by T.b. to determine potential biomarkers of this event. Chronic radiotelemetric monitoring in Sprague-Dawley rats was used to continuously record electroencephalogram, electromyogram, rest-activity, and body temperature in the same animals before (baseline recording) and after infection. Rats were infected with T.b. brucei. Data were acquired from 1 to 20 d after infection (parasite neuroinvasion initiates at 11-13 d post-infection in this model), and were compared to baseline values. Sleep parameters were manually scored from electroencephalographic-electromyographic tracings. Circadian rhythms of sleep time, slow-wave activity, rest-activity, and body temperature were studied using cosinor rhythmometry. Results revealed alterations of most of the analyzed parameters. In particular, sleep pattern and sleep-wake organization plus rest-activity and body temperature rhythms exhibited early quantitative and qualitative alterations, which became marked around the time interval crucial for parasite neuroinvasion or shortly after. Data derived from actigrams showed close correspondence with those from hypnograms, suggesting that rest-activity could be useful to monitor sleep-wake alterations in African trypanosomiasis.

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Section: Cosinor Rhythmometrymentioning

confidence: 99%

Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat

Etet

Palomba

Colavito

et al. 2012

Chronobiology International

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“…Chronomics, the mapping of chronomes (time structures) [7,11] (cf. [8][9][10]) is here applied to melatonin, usually regarded as the hormone of the pineal gland, but also synthesized by various extrapineal tissues [12,15,23,25,26].…”

Section: Introductionmentioning

confidence: 99%

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Pöeggeler

Cornélissen

Huether

et al. 2005

Biomedicine & Pharmacotherapy

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In Göttingen, Germany, circadian variations in melatonin had been determined time-macroscopically in pineal glands, blood plasma and duodenum of chicken and rats. When these data were metaanalyzed, they agreed with the results from an independent survey on tissues from rats collected in a laboratory in Pécs, Hungary. In the latter study, tissues were analyzed chemically in Bratislava, Slovakia, and numerically in Minneapolis, MN, USA, all by single-and multiple-component cosinor and parameter tests. In rats and chickens, these inferential statistical procedures clearly demonstrated a lead in phase of the 24-h cosine curves best fitting all of the duodenal vs. those best fitting all of the pineal melatonin values in each species in 2 geographic (geomagnetic) locations. The 24-h cosine curve of circulating melatonin was found to be in an intermediate phase position. Mechanisms of the phase differences and the contribution of gastrointestinal melatonin to circulating hormone concentrations are discussed.

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“…Other results in this knockout mouse also indicate deficits in attachment behavior. Indeed, molecular mechanisms for conditions characterized by deficits in attachment behavior, such as an opioid receptor gene [61SSS], deserve continued investigation; but this is best carried out with consideration for a spectrum of magnetoperiodisms analyzed by chronomics that complement genomics [62].…”

Section: Discussionmentioning

confidence: 99%

Chronomics of autism and suicide

Halberg

Cornélissen

Panksepp

et al. 2005

Biomedicine & Pharmacotherapy

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We examine whether autism may be influenced by non-photic environmental factors, among others, in a California database consisting of the number of cases added quarterly to the system between 1993 and 2004. Instead of a precise calendar (1.0)-year-long spectral component, we detect unseen primarily helio-and geomagnetic signatures, including a newly discovered near-transyear of 1.09-year length. In this case, it overrides any undetected seasonal effects, the topic of much previous unrewarding research, also analyzed herein without overcoming the limitation by stacking. Since we could not get additional data on autism, data on suicides, the final "detachment" and failure to bond, were also analyzed, again revealing a spectrum of non-photic signatures. What we do not see and do not anticipate can exist and can override the seasons, as resolved time-microscopically by chronomics, the study of chronomes (time structures). Just as spatial microscopy and electron microscopy resolved infectious agents, so does microscopy in time resolve the signature of environmental agents in human behavior in health and disease.

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Chronomics

Cited by 31 publications

References 45 publications

Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat

Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Chronomics of autism and suicide

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