Chronomedicine

Corn��lissen, Germaine; Halberg, Franz

doi:10.1002/0470011815.b2a08010

Cited by 19 publications

(15 citation statements)

References 18 publications

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“…BP and HR measurements were plotted as function of time and analyzed by single cosinor [28,29]. This approach consists of fitting by least squares a cosine function with a given period (24 h) to the data.…”

Section: Methodsmentioning

confidence: 99%

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Circadian rhythm of maternal blood pressure and fetal growth

Maggioni¹,

Cornelissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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This study aimed at examining any relation between the circadian variation in blood pressure (BP) in human pregnancy and fetal growth. A prospective study included 52 pregnant women monitored during the third trimester of pregnancy. There were 33 uncomplicated pregnancies with normal fetal growth (Group 1) and 19 pregnancies complicated by intrauterine growth retardation (IUGR), confirmed at birth (Group 2). Ten women (five in each group) had pregnancy-induced hypertension. All women were hospitalized and followed a similar daily routine. BP was recorded with an automatic wearable device. Measurements were obtained every 20 min for 24 ± 1 h. BP profiles were analyzed by conventional statistical methods and by cosinor, involving the least squares fit of cosine curves with an anticipated period (24 h) to the data. BP parameters, fetal outcome, demographic and obstetric characteristics were compared between the two groups. Logistic regression and multivariate analyses were used to assess factors putatively associated with fetal outcome. The circadian amplitude of diastolic BP was found to be larger in normotensive women with IUGR. As gauged by odds ratios (OR), the circadian amplitude of diastolic BP (OR = 1.7, 95% CI: 1.1-2.8; P = 0.03) and hematocrit (OR = 1.4, 95% CI: 1.0-1.9; P = 0.04) were the only variables positively and independently associated with IUGR. In the presence of maternal hypertension, the circadian amplitude of systolic BP was negatively associated with IUGR (OR = 0.7, 95% CI: 0.5-1.0; P = 0.03). A larger circadian variation in diastolic BP, rather than a difference in the mean value of systolic or diastolic BP, was found to be statistically significantly associated with IUGR. This study adds another condition in which the circadian BP amplitude constitutes a harbinger of elevated risk, apart from an association with a shortened lifespan in the absence or presence of malignant hypertension and with an increased risk of stroke and nephropathy reported earlier.

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Section: Methodsmentioning

confidence: 99%

“…Statistical significance is reached for a probability less than 5%. Results were summarized for each group by population-mean cosinor [28,29] and compared by parameter tests [30].…”

Section: Methodsmentioning

confidence: 99%

Circadian rhythm of maternal blood pressure and fetal growth

Maggioni¹,

Cornelissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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“…RNAs and proteins, published earlier by others [12,13], were quantitatively evaluated by interval as well as point estimates obtained by chronobiological microscopic methods [9][10][11]. The statistical significance of intervals among events following each other in time was estimated [14] to start maps at all levels of organization [15][16][17][18][19][20][21].…”

Section: Methodsmentioning

confidence: 99%

“…Concentrations of those substances were recorded around the clock 6-12 times per day and corresponding graphs were plotted in the original publications [12,13]. The abscissas and ordinates of these plots were taken off and the data were fitted with 24-h cosine curves, computing the acrophases and their 95% confidence intervals by least squares (cosinor) approximations [8][9][10][11]. By parameter tests [14], P-values were obtained for the test of equality of acrophases of all rhythms investigated.…”

Section: Methodsmentioning

confidence: 99%

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Time microscopy for all kinds of data including circadian clock biology

Katinas

Halberg

Cornélissen

et al. 2005

Biomedicine & Pharmacotherapy

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Data showing a rhythm to the naked eye prominently, barely or not at all were described as kinds A, B and C, respectively. Here, we document good agreement between estimates of maxima and minima with eyeballing and with the addition of point and interval estimates of parameters in kind A data. We also construct a chart that provides estimates of uncertainties that can be obtained objectively while they are more difficult to quantify subjectively; again there is agreement. Interval as well as point estimates of rhythm characteristics and parameter comparisons are useful in charting all kinds of data and become indispensable as we proceed from kind A to kind C data. Illustrations included herein from molecular biology apply equally to all aspects of transdisciplinary science.

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Circadian Time Structure of Circulating Plasma Lipid Components in Healthy Indians of Different Age Groups

Singh

Sharma²,

Singh³

et al. 2015

Ind J Clin Biochem

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The circadian rhythm of human circulating lipid components was studied under nearnormal tropical conditions in 162 healthy volunteers (103 males and 59 females; 7 to 75 years of age). They followed a diurnal activity from about 06:00 to about 22:00 and nocturnal rest. These volunteers were divided into four groups: Group A (7-20 years), Group B (21-40 years), Group C (41-60 years) and Group D (61-75 years), comprising 42, 60, 35 and 25 participants, respectively. A marked circadian rhythm was demonstrated for each studied variable in each group by population-mean cosinor analysis (almost invariably p \ 0.001). Furthermore, circadian rhythm characteristics were compared among the 4 groups by parameter tests and regressed as a function of age, separately for males and females. A second-order polynomial characterized the MESOR of HDL cholesterol, phospholipids and total lipids, as well as the 24-h amplitude of total cholesterol and phospholipids. The 24-h amplitude of total lipids decreased linearly with age. The 24-h acrophase of the oldest age group (Group D) was advanced in the case of total cholesterol, HDL cholesterol, and total lipids, whereas that of phospholipids was delayed. Mapping the circadian rhythm (an important component of the broader time structure or chronome, which includes a. o., trends with age and extra-circadian components) of lipid components is needed to explore their role in the aging process in health.

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Chronomedicine

Cited by 19 publications

References 18 publications

Circadian rhythm of maternal blood pressure and fetal growth

Circadian rhythm of maternal blood pressure and fetal growth

Time microscopy for all kinds of data including circadian clock biology

Circadian Time Structure of Circulating Plasma Lipid Components in Healthy Indians of Different Age Groups

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