Chronology of principal and comorbid syndromes in first-episode psychosis

Strakowski, S. M.; Pe, Keck; McElroy, Sharon; Lonczak, Heather S.; Tugrul, K.L.; West, Sophie

doi:10.1016/0006-3223(94)90690-4

Cited by 13 publications

(20 citation statements)

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Section: Prevalence Ratesmentioning

confidence: 59%

“…Variation in prevalence rates among different psychiatric disorders was nicely shown by two similar, methodologically Table 4 27.5% had at least one additional anxiety disorder sound studies [36,38]. The first showed the highest rates of medical and psychiatric comorbidity in schizophrenia spectrum disorders [36] and the second showed higher rates of total comorbidity in affective psychoses [38], in line with Garvey et al [34]. Cosoff and Hafner [40] found similar rates of anxiety disorders among the three patient groups (schizophrenia, schizoaffective disorder and bipolar affective disorder) with the exception of a higher rate of OCD in bipolar disorder, where females predominated.…”

Section: Prevalence Ratesmentioning

confidence: 93%

“…Other studies using rating scales for diagnosing OCS also found higher rates [58,60,65] than those using structured interviews [69,47]. The prevalence of OCD itself varied according to the sample studied, ranging from 4% [47] to 20% [36], with most of the results between 11 and 15%, for patients with the shorter duration of psychotic illness [36,38,59,69]. The exceptions, however, were the studies of Iida et al [55] and Nechmad et al [70], which found a rate of OCS of 41% during the prodrome of childhood onset schizophrenia, and a 26% rate of OCD in adolescents with SSDs, respectively.…”

Section: Obsessive-compulsive Disorder (Ocd) or Obsessivecompulsive Smentioning

confidence: 98%

“…They found few differences between the groups (those with premorbid anxiety had poorer work adjustment and higher rates of simple/specific phobia, whilst suicidal ideation was more common in those with concurrent or subsequent anxiety), and questioned the usefulness of a primary/secondary distinction based on temporality. Strakowski et al [38], in a first episode SSD group, found that all of the anxiety disorders (except PTSD) had an onset antedating that of psychotic symptoms. Cosoff and Hafner [40] found that in 50% of ( DIS-lay interviewers DSM-III "Phobia"-includes all phobias PD 29.5% see Table 1 see Table 1 67% of females in comorbid panic group and 100% of males had comorbid drug or alcohol abuse or dependence Table 1 comorbid patients, anxiety disorders preceded schizophrenia by 2 to 5 years; in 7% onset was concurrent; and in 43% it post-dated schizophrenia by 2 to 5 years.…”

Section: Temporal Relationship Between Ssds and Comorbid Anxiety Disomentioning

confidence: 98%

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Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

Castle¹

2006

CPSR

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Objective: We conducted a comprehensive review of the English language literature on the comorbidity of anxiety symptoms/disorders in schizophrenia spectrum disorders (SSDs) in order to determine: their prevalence rates in clinical and non-clinical populations, the temporal relationship of anxiety comorbidity to SSDs, and the effect of comorbidity on outcome.Results: Overall lifetime prevalence rates for any anxiety disorder ranged from 30% to 85% with most studies showing rates higher than in the general population. In more than 50% of patients, the anxiety disorder preceded the onset of psychosis. Patients with comorbid panic symptoms were more frequent service users, had additional comorbidities and were more likely to be suicidal. Comorbid obsessive-compulsive symptoms (OCS) tended to be associated with poorer social functioning, worse cognitive impairment and motor symptoms.Conclusions: There is a clear link between SSDs and anxiety disorders though its nature remains unclear. This has important implications for psychiatric nosology, aetiology and treatment.

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Section: Prevalence Ratesmentioning

confidence: 59%

Section: Prevalence Ratesmentioning

confidence: 93%

Section: Obsessive-compulsive Disorder (Ocd) or Obsessivecompulsive Smentioning

confidence: 98%

Section: Temporal Relationship Between Ssds and Comorbid Anxiety Disomentioning

confidence: 98%

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Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

Castle¹

2006

CPSR

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“…davantage de ré sistance aux traitements antipsychotiques [19] et un plus grand nombre de rechutes [20] ; des ré missions plus lentes et moins complè tes des dé compensations de la maladie [15] ; un dé clin cognitif plus rapide et plus marqué [21] ; un risque plus é levé de dé pression et d'abus de substance [22] ; davantage de troubles du comportement et de perturbations sociales graves [23]. La méta-analyse de Perkins et al [5] portant sur 43 études de sujets inclus lors d'un premier épisode psychotique confirme une corrélation entre une courte DPNT et une meilleure efficacité des antipsychotiques, mais aussi entre une longue DPNT et une sévérité de la symptomatologie négative et du retentissement cognitif de la maladie.…”

Section: Le Repérage Précoce Des Psychoses éMergentes : Intérêts Et Dunclassified

Diagnostic précoce dans la schizophrénie : une mission pour les médecins généralistes ?

et al. 2011

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Pharmacological intervention in the initial prodromal phase of psychosis

et al. 2005

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Early identification and treatment of schizophrenia may alleviate the symptoms, delay the onset and improve the outcome of psychosis. Thus, detection of individuals at risk during the prodromal phase is an important task. Universal approaches to screen the general population or healthy subjects at risk have not proven possible to-date. However, clinical criteria for detecting ultra-high risk individuals have been developed for specialized settings, with their implementation in interventional studies. This article examines the rationale for early detection and intervention of psychosis, along with a review of some of the current studies. These target prevention using psychological and/or pharmacological intervention strategies have demonstrated promising results in high risk individuals. The German Research Network on Schizophrenia (GRNS) is conducting two multicenter early intervention studies; one with early psychological intervention in subjects who manifest early prodromal symptoms; with the second trial applying clinical management and pharmacological early intervention in subjects experiencing late prodromal symptoms (high risk subjects). Despite the promising results, many of the current studies have small sample sizes with study durations of a short period. The full benefits of early detection and intervention should be revealed once larger and longer studies are conducted.

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Chronology of principal and comorbid syndromes in first-episode psychosis

Cited by 13 publications

References 0 publications

Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

Prevalence of Comorbid Anxiety Disorders in Schizophrenia Spectrum Disorders: A Literature Review

Diagnostic précoce dans la schizophrénie : une mission pour les médecins généralistes ?

Pharmacological intervention in the initial prodromal phase of psychosis

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