Chronology of confluent and reticulated papillomatosis: Spontaneous regression in a case after long‐term follow‐up may imply transient nature of the condition

Tomo, Saygo; Amagai, Masayuki; Ohyama, Manabu

doi:10.1111/1346-8138.12776

Cited by 6 publications

(5 citation statements)

References 5 publications

(15 reference statements)

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“…Of note, two cases of spontaneous resolution of CRP without any treatment have been reported 18,71. The time to achieving resolution ranges from 12 months to 39 months.…”

Section: Prognosismentioning

confidence: 99%

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Lim¹,

Tey²,

Chong³

2016

CCID

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Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud was first typified in 1927. With the help of electron microscopy, it has been elucidated that CRP arises due to aberrant keratinization. However, till date, there is no clear consensus on the etiologic trigger for CRP. Prevailing postulates include a bacterial trigger by Dietzia papillomatosis (type strain N 1280T), an exaggerated cutaneous response to Malassezia furfur, an endocrine basis stemming from insulin resistance, ultraviolet light-induced epidermal change, amyloid deposition, and a loss-of-function mutation in keratin 16. CRP typically presents as asymptomatic hyperpigmented papules and plaques with peripheral reticulation over the nape, axillae, upper chest, and upper back, occasionally with extension superior to the forehead and inferior to the pubic region. Dermoscopy may be used in the evaluation of CRP, but its diagnosis is made on clinical grounds given its nonspecific histopathological findings. Although successful treatment with topical keratolytics, retinoids, or antifungals has been reported, antibiotics, such as minocycline, at anti-inflammatory doses have emerged as a preferred therapeutic option. In this article, we review the diagnostic considerations in CRP and its therapeutic options.

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“…Of note, two cases of spontaneous resolution of CRP without any treatment have been reported 18,71. The time to achieving resolution ranges from 12 months to 39 months.…”

Section: Prognosismentioning

confidence: 99%

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Lim¹,

Tey²,

Chong³

2016

CCID

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“…5 Some authors believe that the condition is transitory, can resolve on its own and may not require active therapy. 6 However, as our patient had the condition for 7 years and was slowly progressive, wait-and-watch may not be a feasible option in most cases.…”

Section: Discussionmentioning

confidence: 86%

Confluent and Reticulated Papillomatosis of Carteaud and Gougerot in a Young Nepali Male

Amatya

Sharma

Syed

et al. 2020

Nepal J Dermatol Venereol & Leprol

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Confluent and reticulated papillomatosis of Carteaud and Gougerot is a keratinization disorder with an infective aetiology. Patients present with hyperpigmented papules on the upper trunk and axillae that coalesce centrally and demonstrate reticulation peripherally. Diagnosis is based on clinical findings, characteristic histopathologic changes and response to therapy. We report a case of a young Nepali male who presented with gradual onset of asymptomatic raised dark brown lesions on his neck, trunk and axillae over the course of eight years. The condition was previously misdiagnosed as pityriasis versicolor and had received oral and topical antifungals. The diagnosis was revised to confluent and reticulated papillomatosis based on clinical and histopathological examination. He was subsequently started on oral minocycline 50 mg twice daily and nightly application of topical tretinoin 0.05% gel. There was complete resolution of all his lesions except for residual hyperpigmentation at the end of two months of therapy. There has been no relapse six months from the end of therapy. This is to our knowledge, the first case of confluent and reticulated papillomatosis reported from Nepal. Oral minocycline and topical tretinoin should be considered first line in the treatment of confluent and reticulated papillomatosis.

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“…Unclear. Genetic mutation, UV radiation, endocrine disorders e.g., insulin resistance, diabetes mellitus, hypothyroidism, pituitary, menstrual irregularities, aberrant reaction to Malassezia furfur or Dietzia spp., or abnormal keratinization [5].…”

Section: Etiologymentioning

confidence: 99%

Prurigo Pigmentosa: A Case Report With Unusual Presentation

Altalhi¹,

Azhari²,

Aljuhani³

et al. 2022

Cureus

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Prurigo pigmentosa (PP) is an idiopathic cutaneous inflammatory disorder. Here we report a 50-year-old healthy male of Arabic descent who presented with a six-month history of very itchy persistent skin lesions on his back. Skin examination revealed multiple brownish non-scaly excoriated papules and patches in the midline of his lower back. The differential diagnosis includes lichen planus (LP), confluent and reticulated papillomatosis (CARP), and PP. Skin biopsy revealed acanthosis, spongiosis, and dyskeratotic keratinocytes in the epidermis. The dermis showed mild perivascular lymphocytic infiltrate. Based on the previous clinicopathological findings, the patient was diagnosed with PP. He was prescribed doxycycline 100 mg once daily (OD) for two months. Two months after treatment, all lesions disappeared completely. After one year at the follow-up, he presented with a recurrence of the same skin lesions at the same site. We restarted him on doxycycline treatment.

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Chronology of confluent and reticulated papillomatosis: Spontaneous regression in a case after long‐term follow‐up may imply transient nature of the condition

Cited by 6 publications

References 5 publications

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Confluent and Reticulated Papillomatosis of Carteaud and Gougerot in a Young Nepali Male

Prurigo Pigmentosa: A Case Report With Unusual Presentation

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