Chronological changes in the epidemiological characteristics of upper urinary tract urolithiasis in Japan

Sakamoto, Shinichi; Miyazawa, Katsuhito; Yasui, Takahiro; Iguchi, Taro; Fujita, Misuzu; Nishimatsu, Hiroaki; Masaki, Takuro; Hasegawa, Tomohiko; Hibi, Hatsuki; Arakawa, Takeo; Ando, Ryosuke; Kato, Yoshinari; Ishito, Noritaka; Yamaguchi, Satoshi; Takazawa, Ryoji; Tsujihata, Masao; Matsuda, Tadashi; Akakura, Koichiro; Hata, Akira; Ichikawa, Tomohiko

doi:10.1111/iju.13552

Cited by 38 publications

(47 citation statements)

References 18 publications

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“…The annual incidence of upper tract urolithiasis in Korea was estimated to be 457.02 per 100 000 in the overall population, with 589.09 per 100 000 men and 326.64 per 100 000 women . In Japan, the estimated annual incidence of a first‐episode upper urinary tract stone in 2015 was 137.9 (191.9 in men and 86.9 in women) per 100 000 . In Taiwan, the prevalence of urolithiasis was 7.4% in 2010, and these results were similar to those in Western countries …”

Section: Introductionmentioning

confidence: 64%

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Recent surgical treatments for urinary stone disease in a Korean population: National population‐based study

et al. 2019

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Objectives To provide surgical treatment trends for urinary stone disease in Korea. Methods We analyzed medical service claim data of surgical treatments to urinary stone disease submitted by medical service providers from the Health Insurance Review and Assessment Service from 2009 to 2016. Results There was a significantly increasing trend among outpatients and inpatients for urinary stone disease from 2009 to 2016 (R2 = 0.643, P = 0.017; R2 = 0.575, P = 0.029). The number of shock wave lithotripsy for treating urinary stone disease increased by 16% from 89 553 in 2009 to 104 013 in 2016 (R2 = 0.684). The number of ureteroscopic lithotripsy increased by 97% from 6106 in 2009 to 12 057 in 2016 (R2 = 0.99). The number of flexible ureteroscopic lithotripsy increased by 16‐fold from 219 in 2009 to 3712 in 2016 (R2 = 0.756). The number of percutaneous nephrolithotomy increased by 99.7% from 919 in 2009 to 1835 in 2016 (R2 = 0.987). The use of non‐contrast and contrast‐enhanced computed tomography in the diagnostic codes for urinary stone disease increased by 394.8% and 263.3% from 2009 to 2016, respectively (R2 = 0.83; R2 = 0.967). Conversely, the use of intravenous pyelography decreased 26.2% over the same period (R2 = 0.945). Conclusions Outpatient and inpatient procedures for urinary stone disease have increased over the past 8 years in Korea. Shock wave lithotripsy is the most widely used treatment modality for urinary stone disease, and endoscopic surgical procedures are rapidly being implemented. There has been a steep increase in the use of computed tomography, whereas conventional intravenous pyelography is declining.

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Section: Introductionmentioning

confidence: 64%

“…Sakamoto et al . reported that the proportion of patients receiving SWL decreased to 60.4% in 2015 compared with 91.2% in 1995 . In contrast, a remarkable increase was observed in the proportion of patients receiving PNL and/or URS in the past 10 years.…”

Section: Discussionmentioning

confidence: 99%

Recent surgical treatments for urinary stone disease in a Korean population: National population‐based study

et al. 2019

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“…Fourth, the increased incidence of upper urinary tract stones might reflect the increased incidence of lower urinary tract stones. Based on the epidemiology of upper urinary tract stones in Japan, the incidence of upper urinary tract stones increased from 43.7 per 100 000 to 137.9 per 100 000 between 1965 and 2015 . Furthermore, an increased composition of calcium oxalate stone among lower urinary tract stones might also support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…We collected data regarding lower urinary tract stones from four published nationwide surveys of urolithiasis . The materials and methods applied in the surveys are described elsewhere . In brief, questionnaires were posted to 1210 hospitals in January 2015 to estimate the total number of Japanese patients with stones, and 459 of them responded.…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, the incidence of lower urinary tract stones has remained relatively stable. A nationwide survey of urolithiasis in 2015 discovered that the incidence of upper urinary tract stones had stabilized between 2005 and 2015 . Novel trends in upper urinary tract stones might reflect environmental and nutritional changes, as well as the development of clinical diagnostic procedures.…”

Section: Introductionmentioning

confidence: 99%

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Chronological changes in epidemiological characteristics of lower urinary tract urolithiasis in Japan

et al. 2018

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Objectives To determine changes and trends in the annual incidence and epidemiological aspects of lower urinary tract stones in Japan. Methods Data about patients who had been diagnosed by urologists in 2015 with first and recurrent lower urinary tract stones were collected from 301 hospitals approved by the Japanese Board of Urology. The estimated annual incidence according to sex, age and stone composition was compared with previous nationwide surveys between 1965 and 2005. Results The incidence of lower urinary tract stones in Japan has steadily increased from 4.7 per 100 000 in 1965 to 12.0 per 100 000 in 2015. However, the age standardized annual incidence of lower urinary tract stones has remained relatively stable over the same period at 5.5 per 100 000 and 6.0 per 100 000 in 1965 and 2015, respectively. The increase in incidence was most evident among individuals aged ≥80 years. The incidence of calcium oxalate stones has steadily increased among males and females, whereas that of infection‐related stones has significantly decreased from 26.2% to 14.3% among men over the past 50 years. Conclusions Nationwide surveys suggest a steady increase in the incidence of lower urinary tract stones over a 50‐year period in Japan. This trend might reflect changes in the aging population and improved Japanese medical standards.

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Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Takahashi

Sasaki²,

Shimizu

et al. 2023

Clinical Pharm in Drug Dev

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Dotinurad has been approved in Japan as a selective urate reabsorption inhibitor for the treatment of gout and hyperuricemia. The relationship between uric acid crystallization and the use of uricosuric drugs is widely acknowledged; however, the relationship between changes in urinary uric acid concentration and urine pH or volume has not been sufficiently analyzed. Therefore, we investigated the changes in urinary uric acid concentration following dotinurad administration as well as the relationship between urine pH or volume and urinary uric acid concentration. This post hoc analysis used data from 2 clinical trials that included 12 and 26 patients with hyperuricemia who received dotinurad treatment (for 7 days on an inpatient basis and 14 weeks on an outpatient basis, respectively). The urinary uric acid concentration transiently increased in the early stages of dotinurad use and when its dose was increased, but decreased over time. No uric acid concentrations exceeded the soluble limit at any urine pH. An inverse correlation was observed between urine volume and urinary uric acid concentration. This study highlights the significance of adequately managing urinary uric acid concentrations by increasing urine volume and alkalinizing urine to prevent uric acid crystallization during dotinurad administration.

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Chronological changes in the epidemiological characteristics of upper urinary tract urolithiasis in Japan

Cited by 38 publications

References 18 publications

Recent surgical treatments for urinary stone disease in a Korean population: National population‐based study

Recent surgical treatments for urinary stone disease in a Korean population: National population‐based study

Chronological changes in epidemiological characteristics of lower urinary tract urolithiasis in Japan

Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

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